Deck 17: Tumor Immunology

Question 1

In which of the following conditions would you not see an increase in alpha-fetoprotein?

A) Pregnancy
B) Hepatocellular carcinoma
C) Hepatitis
D) Hypercholesteremia

Answer 1

Hypercholesteremia

Question 2

A tumor that is classified as malignant is described as:

A) a disorganized mass that is not encapsulated and can invade nearby organs.
B) a slow-growing, organized mass of encapsulated cells.
C) usually confined to the skin.
D) an area of swelling that shows no abnormal growth of cells.

Answer 2

a disorganized mass that is not encapsulated and can invade nearby organs.

Question 3

What is the definition of a sarcoma?

A) A cancer that is derived from skin or epithelial linings of internal organs or glands
B) A cancer that is derived from muscle, bone, fat or soft tissues
C) A cancer that is derived from blood and lymphatic systems
D) A cancer that is derived from brain and spinal tissue

Answer 3

A cancer that is derived from muscle, bone, fat or soft tissues

Question 4

Match the tumor marker to its associated disease.

Carcinoembryonic antigen

A)Hepatocellular carcinoma
B)Ovarian cancer
C)Colorectal, breast, or lung cancer
D)Breast cancer only
E)Pancreatic and gastrointestinal cancers

Question 5

Match the tumor marker to its associated disease.

Alpha-fetoprotein

A)Hepatocellular carcinoma
B)Ovarian cancer
C)Colorectal, breast, or lung cancer
D)Breast cancer only
E)Pancreatic and gastrointestinal cancers

Question 6

What is the definition of a carcinoma?

A) A cancer that is derived from skin or epithelial linings of internal organs or glands
B) A cancer that is derived from muscle, fat, and soft tissues
C) A cancer that is derived from blood and lymphatic systems
D) A cancer that is derived from brain and spinal tissue

Question 7

A tumor-specific antigen is:

A) a general marker for all known human tumors.
B) a specific marker for leukemias.
C) unique to the tumor of an individual patient.
D) nonspecific to all patient populations.

Question 8

A proto-oncogene is a normal gene that has a positive influence on cell proliferation.

Question 9

Match the tumor marker to its associated disease.

Cancer antigen 19-9

A)Hepatocellular carcinoma
B)Ovarian cancer
C)Colorectal, breast, or lung cancer
D)Breast cancer only
E)Pancreatic and gastrointestinal cancers

Question 10

Carcinogenesis is thought to be initiated by the exposure of the host to factors such as bacteria.

Question 11

Tumor-associated antigens are expressed only in tumor cells.

Question 12

Match the tumor marker to its associated disease.

HER-2

A)Hepatocellular carcinoma
B)Ovarian cancer
C)Colorectal, breast, or lung cancer
D)Breast cancer only
E)Pancreatic and gastrointestinal cancers

Question 13

Which of the following is a clinical application for tumor markers?

A) Screening
B) Diagnosis
C) Monitoring
D) All of the above

Question 14

Match the tumor marker to its associated disease.

Cancer antigen 125

A)Hepatocellular carcinoma
B)Ovarian cancer
C)Colorectal, breast, or lung cancer
D)Breast cancer only
E)Pancreatic and gastrointestinal cancers

Question 15

A woman who has a history of ovarian cancer in her family goes to her physician for a "cancer test." What is the test that is most likely to be positive if the woman has ovarian cancer?

A) Carcinoembryonic antigen
B) Alpha-fetoprotein
C) Cancer antigen 125
D) Human chorionic gonadotropin

Question 16

An example of a tumor-specific antigen is the BCR/ABL protein for chronic myelogenous leukemia.