Deck 45: Principles of Antimicrobial Use

Question 1

For the treatment of meningitis, all of the following could be effective except:

A) Rifampin
B) Chloramphenicol
C) Ampicillin
D) Gentamicin
E) Ciprofloxacin

Answer 1

Gentamicin

Question 2

The aminoglycoside class of antibiotics has which of the following toxicities?

A) Ototoxicity
B) Nephrotoxicity
C) Hepatotoxicity
D) A and B
E) A, B, and C

Answer 2

A and B

Question 3

Methicillin-resistant Staphylococcus aureus (MRSA) has developed resistance to all β-lactams by what mechanism?

A) Nonreactive receptor on the bacterial cell surface that binds the antibiotic
B) Destruction of the β-lactam ring upon attachment to the mutated receptor
C) Mutated protein that acts to hydrolyze β-lactams
D) Acquisition onto the penicillin-binding site of a novel protein called PBP2a.

Answer 3

Acquisition onto the penicillin-binding site of a novel protein called PBP2a.

Question 4

Antimicrobial agents that disrupt or inhibit nucleic acid synthesis are:

A) Clindamycin and lincomycin
B) β-Lactams, cephalosporins, and vancomycin
C) Quinolones and rifampin
D) Amikacin and gentamicin
E) Chloramphenicol