Deck 44: Calcium-Regulating Hormones and Other Agents Affecting Bone

Question 1

Regarding the pharmacologic class of bisphosphonates:

A) An example is teriparatide
B) At high doses inhibit osteoclasts
C) One example is calcitonin
D) Have less gastrointestinal side effects than other anti-osteoporosis drugs
E) Are usually prescribed for once-daily administration

Answer 1

Are usually prescribed for once-daily administration

Question 2

Selective estrogen receptor modulators (SERMs) are known to inhibit bone resorption and prevent fractures. Their mechanism of action is:

A) Decrease production of interleukins that up regulate osteoclasts
B) Promote follicular production of progesterone, prostaglandin F_2α, and proteolytic enzymes
C) Suppress the hypothalamic-pituitary axis
D) Decrease plasma calcium levels
E) Increase activity of the hypothalamic GnRH pulse generator

Answer 2

Decrease production of interleukins that up regulate osteoclasts