Question 1

All of the following may lead to deficiencies of clotting factors except:&#10;A)Renal disease&#10;B)Liver disease&#10;C)Autoimmune disease&#10;D)Cardiovascular disease

Accepted Answer

Liver disease can lead to deficiencies in clotting factors because the liver is responsible for producing most of the clotting factors. Renal disease can contribute to a reduction in clotting factors through various mechanisms, including the loss of proteins in the urine and impaired metabolism. Autoimmune diseases can lead to the production of antibodies against clotting factors, reducing their levels or function. However, cardiovascular disease primarily affects the heart and blood vessels and does not directly lead to deficiencies in clotting factors.

Question 2

Long-term antibiotic therapy is a cause of bleeding because it disrupts:&#10;A)Vitamin K synthesis&#10;B)Contact activation&#10;C)Platelet aggregation&#10;D)Fibrinolytic activity

Accepted Answer

Long-term antibiotic therapy can disrupt the gut flora, which is responsible for synthesizing vitamin K, an essential factor for blood clotting. This disruption can lead to a deficiency in vitamin K, causing bleeding problems.

Question 3

The treatment of choice for hemophilia A individuals is:&#10;A)Cryoprecipitate&#10;B)Recombinant factor VIII&#10;C)Prothrombin complex&#10;D)DDAVP

Accepted Answer

Recombinant factor VIII is the treatment of choice for hemophilia A, as it directly replaces the deficient clotting factor in these patients.

Question 4

Which of the following is not a vitamin K-dependent factor?&#10;A)Factor VIII&#10;B)Factor II&#10;C)Factor VII&#10;D)Factor IX

Accepted Answer

Factor VIII is not a vitamin K-dependent factor. Vitamin K-dependent factors include II, VII, IX, and X, along with protein C and S, but not factor VIII. Factor VIII is involved in the intrinsic pathway of blood coagulation and is not vitamin K-dependent.

Question 5

Patients with hemophilia A or B have abnormal results in which coagulation assay?&#10;A)APTT&#10;B)PT&#10;C)Fibrinogen assay&#10;D)Platelet count

Accepted Answer

Hemophilia A and B are characterized by deficiencies in factors VIII and IX, respectively, which are part of the intrinsic pathway. The activated partial thromboplastin time (APTT) test evaluates the intrinsic pathway and is prolonged in these conditions. PT, fibrinogen assay, and platelet count typically remain normal.

Question 6

Which of the following is the most prevalent inherited bleeding disorder?&#10;A)Hemophilia A&#10;B)Hemophilia B&#10;C)Factor VII deficiency&#10;D)von Willebrand Disease

Accepted Answer

von Willebrand Disease is the most common inherited bleeding disorder, affecting both males and females, and is caused by a deficiency or dysfunction of the von Willebrand factor.

Question 7

A patient with 8% factor VIII activity has which form of hemophilia?&#10;A)Severe&#10;B)Moderate&#10;C)Mild&#10;D)Asymptomatic

Accepted Answer

Mild hemophilia is characterized by factor VIII activity levels between 5% and 40%. A patient with 8% factor VIII activity falls within this range.

Question 8

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?&#10;A)A familial pattern of inheritance&#10;B)Patient's history&#10;C)Activated partial thromboplastin time&#10;D)Factor assays

Accepted Answer

Factor assays are the most useful in differentiating hemophilia A from hemophilia B because they measure the activity of specific clotting factors. Hemophilia A is caused by a deficiency in factor VIII, while hemophilia B is caused by a deficiency in factor IX.

Question 9

Keloid scar formation is most commonly associated with:&#10;A)Factor VIII deficiency&#10;B)Factor IX deficiency&#10;C)Factor XII deficiency&#10;D)Factor XIII deficiency

Accepted Answer

Keloid scar formation is associated with Factor XIII deficiency, which plays a role in wound healing and scar formation.

Question 10

A man with hemophilia A and an unaffected female can produce a:&#10;A)Female carrier&#10;B)Male carrier&#10;C)Male with hemophilia A&#10;D)Normal female

Accepted Answer

C  D  A man with hemophilia A (X-linked recessive) will pass his affected X chromosome to all his daughters, making them carriers. Sons receive their father's Y chromosome, so they cannot be carriers but can be affected if they inherit the affected X from their mother. If the mother is unaffected and not a carrier, sons will be normal. Daughters can be normal if they inherit the unaffected X from their mother.

Question 11

The only clotting factor not synthesized exclusively by the liver is factor:&#10;A)V&#10;B)VII&#10;C)VIII&#10;D)IX

Accepted Answer

The answer of The only clotting factor not synthesized exclusively...

Question 12

Christmas disease is another name for:&#10;A)Hemophilia A&#10;B)Hemophilia B&#10;C)von Willebrand's disease&#10;D)Factor VII deficiency

Accepted Answer

The answer of Christmas disease is another name for:&#10;A)Hemophilia A&#10;B)Hemophilia...

Question 13

Treatment of patients with factor II, VII, or X deficiency consists of:&#10;A)Administration of prothrombin complex concentrate&#10;B)Administration of cryoprecipitate&#10;C)Administration of FFP&#10;D)Administration of whole blood

Accepted Answer

The answer of Treatment of patients with factor II, VII,...

Question 14

The following laboratory results have been obtained for a 40-year-old woman with infrequent bleeding: PT = 20 seconds (reference range is 11 to 15 seconds), APTT = 50 seconds (reference range is 22 to 40 seconds).What factor deficiency is most likely?

A)VII
B)VIII
C)X
D)XIII

Accepted Answer

The answer of The following laboratory results have been obtained...

Question 15

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:&#10;A)Normal plasma&#10;B)Adsorbed plasma&#10;C)Factor-deficient plasma&#10;D)Factor-specific plasma

Accepted Answer

The answer of Factor assays measure the percentage of activity...

Question 16

Factor VIII is also known as which?&#10;A)X factor&#10;B)Plasminogen&#10;C)Christmas factor&#10;D)Antihemophilic globulin

Accepted Answer

The answer of Factor VIII is also known as which?&#10;A)X...

Question 17

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?&#10;A)20%&#10;B)30%&#10;C)50%&#10;D)75%

Accepted Answer

The answer of Clotting factors must be present at a...

Question 18

What is a new treatment alternative for hemophilia patients?&#10;A)Recombinant factor VIII&#10;B)Fresh frozen plasma&#10;C)Gene therapy&#10;D)Cryoprecipitate

Accepted Answer

The answer of What is a new treatment alternative for...

Question 19

Which of the following assays will be abnormal with hemophilia A?&#10;A)Platelet count&#10;B)Bleeding time&#10;C)PT&#10;D)aPTT

Accepted Answer

The answer of Which of the following assays will be...

Deck 17: Defects of Plasma Clotting Factors