Deck 18: Fibrinogen, Thrombin, and the Fibrinolytic System

Question 1

Obstetrical complications such as retained placenta or abruptio placenta are leading causes of:

A)Thrombosis
B)DIC
C)ITP
D)TTP

Answer 1

B

Question 2

An excess of which of the following is indicative of the breakdown of fibrin products within the circulating blood?

A)D-dimers
B)Alpha-2-antiplasmin
C)Protein C
D)Plasmin

Answer 2

A

Question 3

The key component to clot dissolution is:

A)Plasminogen
B)Plasmin
C)Thrombin
D)Fibrin

Answer 3

B

Question 4

Which of the following hematology disorders will likely trigger an episode of DIC?

A)Sickle cell disease
B)Iron-deficiency anemia
C)Idiopathic thrombocythemia
D)Acute promyelocytic leukemia

Question 5

The reference range for fibrinogen is:

A)20 to 40 mg/dL
B)100 to 120 mg/dL
C)150 to 450 mg/dL
D)200 to 400 mg/dL

Question 6

Which of these are byproducts of fibrinolysis?

A)Fibrin degradation products and D-dimers
B)Fibrinopeptides A and B
C)Streptokinase and urokinase
D)Alpha 2 antiplasmins

Question 7

D-dimer analysis may have what kind of result in DIC?

A)Normal
B)Low
C)Elevated
D)D-dimer is not an appropriate test for DIC.

Question 8

Normal levels of fibrin degradation products are removed by the reticuloendothelial system and usually measure:

A)Less than 20 µg/mL
B)Less than 40 µg/mL
C)Less than 75 µg/mL
D)Less than 100 µg/mL

Question 9

A patient with DIC will have the all following coagulation test results except:

A)An increased PT/INR
B)An increased aPTT
C)An increased fibrinogen
D)An increased D-dimer

Question 10

The D-dimer test measures:

A)Fibrinogen deposition
B)Fibrinogen degradation
C)Fibrin degradation
D)Fibrin deposition

Question 11

The lowest levels of fibrinogen are seen in which inherited disorder of fibrinogen?

A)Hyperfibrinogenemia
B)Hypofibrinogenemia
C)Dysfibrinogenemia
D)Afibrinogenemia

Question 12

The best component to use for patients with afibrinogenemia is:

A)Whole blood
B)Fresh frozen plasma
C)Tissue plasminogen activator
D)Factor XIII

Question 13

A primary inhibitor of the fibrinolytic system is:

A)Alpha 2 antiplasmin
B)Alpha 2 macroglobulin
C)Antithrombin
D)Protein C

Question 14

A patient with DIC will have all the following coagulation test results except:

A)An increased PT/INR
B)An increased aPTT
C)An increased fibrinogen
D)An increased D-dimer

Question 15

All of the following are functions of thrombin except:

A)Initiating the platelet release reaction
B)Simulating platelets to product PGI₂
C)Activating factors V and VIII
D)Activating thromboplastin

Question 16

The substrate upon which the coagulation cascade is centered is:

A)Thrombin
B)Vitamin K
C)Fibrinogen
D)Fibrin

Question 17

Plasmin causes the inactivation of factors:

A)V, VII, X, XI
B)V, VIII, XI, XII
C)VII, VIII, XI, XII
D)X, XI, XII, XIII

Question 18

Patients with the heterozygous form of afibrinogenemia will have plasma levels of fibrinogen in the range of:

A)0 to 20 mg/dL
B)20 to 100 mg/dL
C)50 to 150 mg/dL
D)100 to 200 mg/dL

Question 19

Primary fibrinolysis is a disorder closely related to DIC.All of the coagulation profile assays are the same as that for DIC with the exception of the:

A)D-dimer level, which is increased
B)Fibrinogen level, which is decreased
C)Platelet count, which is normal
D)PT/INR, which is increased

Question 20

The process of fibrin degradation is called __________ and is controlled by the enzyme _________.

A)fibrination; plasmin
B)fibrinolysis; plasmin
C)fibrination; protease
D)fibrinolysis; protease