Deck 15: Overview of Hemostasis and Platelet Physiology

Question 1

The prothrombin group of factors consists of factors:

A)I, V, VIII, and XIII
B)XI, XII, prekallikrein, and HMWK
C)II, VII, IX, and X
D)III, VIII, IX, and X

Answer 1

C

Question 2

The two inhibitors that keep the activation of coagulation under control are:

A)TFPI and thrombomodulin
B)Protein C and protein S
C)Protease inhibitors and the protein C pathway
D)Alpha 2 macroglobulin and alpha 1 antitrypsin

Answer 2

B

Question 3

A decreased platelet count is most often anticipated when a patient demonstrates:

A)Thrombosis
B)Petechiae
C)Hemarthrosis
D)Glossitis

Answer 3

B

Question 4

The vasoconstrictor substance released from the platelets at the site of injury is:

A)Thrombin
B)Thromboxane A₂
C)Adenosine diphosphate
D)Prostacyclin

Question 5

Factor II is also known as which of the following?

A)Thrombin
B)Fibrinogen
C)Prothrombin
D)Fibrin

Question 6

Which factor is involved in contact activation?

A)Factor X
B)Fibrinogen
C)Fitzgerald factor
D)Factor II

Question 7

The anticoagulant known as heparin:

A)Inhibits PF3 activity
B)Inhibits thrombin activity
C)Degrades antithrombin activity
D)Chelates calcium

Question 8

The average life span of a platelet in a normal adult is:

A)1 to 5 days
B)5 to 7 days
C)7 to 10 days
D)18 to 21 days

Question 9

Which of the following proteins is not made in the liver?

A)Anti-hemophiliac factor
B)Prothrombin
C)Fibrinogen
D)von Willebrand factor

Question 10

The main substrate of the coagulation system is:

A)Calcium
B)ADP
C)Collagen
D)Fibrinogen

Question 11

Tissue factor pathway inhibitor (TFPI):

A)Prevents activation of factor X by VIIa
B)Activates the common pathway
C)Inhibits fibrinolysis
D)Inhibits the kallikrein proteins

Question 12

Which factor is measured by both the PT and the aPTT?

A)VIII
B)IX
C)V
D)XIII

Question 13

Platelets are synthesized in the:

A)Liver
B)Spleen
C)Lymph glands
D)Bone marrow

Question 14

Which organ is responsible for sheltering 20% of the total platelet volume in the circulation?

A)Kidneys
B)Adrenal gland
C)Spleen
D)Liver

Question 15

In the prothrombin test, the patient's citrated plasma is combined with:

A)Phospholipids
B)Thromboplastin only
C)Ca²⁺ and actin
D)Ca²⁺ and thromboplastin

Question 16

The first response of a cut vessel is:

A)Vasoconstriction
B)Platelet aggregation
C)Activation of the intrinsic pathway
D)Vasodilation

Question 17

Platelet aggregation is dependent on the presence of:

A)Calcium ions
B)Sodium citrate
C)Magnesium
D)Potassium

Question 18

Which of the following is not a component of the fibrinolytic system?

A)Thrombin
B)Plasmin
C)Tissue-type plasminogen activator (tPA)
D)Urokinase