Deck 16: Quantitative and Qualitative Platelet Disorders

Question 1

A platelet aggregation defect in which there is a deficiency of GP IIb/IIIa is known as:

A)vWD
B)Glanzmann's thrombasthenia
C)Bernard-Soulier syndrome
D)TTP

Answer 1

B

Question 2

In hemolytic uremic syndrome (HUS), which of the following statements is the most accurate?

A)The organ most affected is the spleen.
B)The toxin responsible for this syndrome is produced by
C)Impaired neurological function is one of the primary symptoms.
D)Platelets are permanently impaired.

Answer 2

The toxin responsible for this syndrome is produced by

Question 3

Which the following test results is normal in a patient with classic von Willebrand's disease?

A)Bleeding time
B)Activated partial thromboplastin time
C)Platelet count
D)Factor VIII and vWF levels

Answer 3

C

Question 4

Which of the following are platelet adhesion disorders?

A)von Willebrand's disease and Glanzmann's thrombasthenia
B)von Willebrand's disease and Bernard-Soulier syndrome
C)Glanzmann's thrombasthenia and Bernard-Soulier syndrome
D)Glanzmann's thrombasthenia and congenital fibrinogenemia

Question 5

A 2-year-old boy develops the following symptoms: petechiae, purpura, and nosebleeds.The platelet count is 18,000.The most likely explanation is:

A)Drug-induced thrombocytopenia
B)Secondary thrombocytopenia
C)Idiopathic thrombocytopenic purpura
D)Thrombotic thrombocytopenic purpura

Question 6

Which of the following causes irreversible inactivation of platelets?

A)Heparin
B)Coumadin
C)Aspirin
D)Vitamin K

Question 7

Increased platelets are seen in which of the following disorders?

A)ITP
B)TTP
C)ET
D)vWD

Question 8

A decreased platelet count is most often anticipated when a patient demonstrates:

A)Rectal bleeding
B)Epistaxis
C)Genitourinary bleeding
D)Severe hemorrhage

Question 9

All of the following are associated with platelet disorders except:

A)Thrombocytopenia
B)Deep muscle hemorrhages
C)Epistaxis and menorrhagia
D)Abnormal platelet morphology

Question 10

Immune drug-induced thrombocytopenia is a result of all of the following drugs except:

A)NSAIDs
B)Heparin
C)Amoxicillin
D)Aspirin

Question 11

Decreased platelets in combination with bloody diarrhea, vomiting, and abdominal pain is seen in which of the following?

A)HUS
B)ITP
C)Glanzmann's thrombasthenia
D)TTP

Question 12

Platelet aggregation cannot occur if _______ is absent.

A)vWF
B)GP IIb/IIIa
C)antibodies
D)GP Ib/IX

Question 13

The autoantibody generated in ITP is directed against:

A)vWF
B)Collagen
C)GP IIb/IIIa, GP Ib/IX
D)Fibrinopeptides A and B

Question 14

All of the following can affect the platelet count except:

A)Improper mixing of specimen
B)Not using a tourniquet
C)Presence of EDTA-antibodies
D)Not using anticoagulated tubes

Question 15

Platelets from patients with which two disorders will not aggregate with ristocetin?

A)Glanzmann's syndrome and von Willebrand's
B)Glanzmann's syndrome and Chediak-Higashi
C)HUS and Bernard-Soulier syndrome
D)von Willebrand's disease and Bernard-Soulier

Question 16

Aspirin therapy irreversibly inhibits the synthesis of:

A)ATP
B)GP 1
C)Prostaglandins
D)GP IIb and IIIa

Question 17

The presence of thrombocytopenia and giant platelets on the peripheral smear of a patient is characteristic of:

A)Classic von Willebrand's disease
B)Hemophilia A
C)Glanzmann's thrombasthenia
D)Bernard-Soulier syndrome

Question 18

In thrombotic thrombocytopenic purpura, which of the following statements is the most accurate?

A)It is associated with
B)It is associated with fever, renal failure, and neurological complications.
C)The organ most affected is the kidney.
D)More males are affected than females

Question 19

Thrombocytosis is defined as a platelet count that is:

A)Greater than 450 × 10⁹/L
B)Less than 450 × w10⁹/L
C)Greater than 600 × 10⁹/L
D)Less than 300 × 10⁹/L