Deck 13: Lymphoproliferative Disorders and Related Plasma Cell Disorders

Question 1

Patients with CLL:

A)Die most often of blast crisis
B)Are usually younger than 40 years
C)May develop monoclonal spikes
D)Often are immunocompromised

Answer 1

D

Question 2

The most characteristic change seen in the peripheral smear of a patient with multiple myeloma is the presence of:

A)Microcytic hypochromic cells
B)Intracellular inclusion bodies
C)Rouleaux
D)Agglutination

Answer 2

C

Question 3

All of the following are related to the pathophysiology of multiple myeloma except:

A)Acceleration of plasma cells in the bone marrow
B)Increased levels of tyrosine kinase activity
C)Activation of osteoclasts
D)Production of an abnormal monoclonal protein

Answer 3

B

Question 4

Which of the following statements is true about chronic lymphoproliferative disorders?

A)Complications are related to overactive immune systems.
B)They are often seen in elderly patients and progress quickly.
C)They are often seen in elderly patients and progress slowly.
D)They are a clonal proliferation of granulocytes.

Question 5

Russell bodies are associated with:

A)Multiple myeloma
B)Hodgkin's lymphoma
C)Non-Hodgkin's lymphoma
D)Waldenström's macroglobulinemia

Question 6

A significant feature of hairy cell leukemia not seen is other acute leukemias is:

A)Panmyelosis
B)Pancytosis
C)Pancytopenia
D)Panhyperplasia

Question 7

The TRAP stain is useful in the diagnosis of:

A)CLL
B)PLL
C)Hairy cell leukemia
D)Hodgkin's lymphoma

Question 8

Which of the following genetic alterations is associated with a poor prognosis in CLL?

A)Trisomy 13
B)Trisomy 12
C)t(15:17)
D)t(9:21)

Question 9

The immunoglobulin responsible for secondary immunological response and a monoclonal over-production in multiple myeloma is:

A)IgA
B)IgM
C)IgD
D)IgG

Question 10

The CD markers associated with CLL include all of the following except:

A)CD 4
B)CD 15
C)CD 19
D)CD 20

Question 11

All of the following are consistent with the clinical and pathological picture of Waldenström's macroglobulinemia except:

A)M spike due to IgM
B)Lymphadenopathy and splenomegaly
C)Proliferation of lymphocytes and plasmacytoid lymphocytes
D)Destructive bone lesions

Question 12

Lymphoma cells in the peripheral smear are associated with:

A)Hodgkin's lymphoma
B)CLL
C)non-Hodgkin's lymphoma
D)Multiple myeloma

Question 13

An abnormal proliferation of B lymphocytes seen in lymph node biopsy with a morphology resembling an owl's eye is commonly associated with:

A)Acute lymphocytic leukemia
B)Chronic lymphocytic leukemia
C)Infectious mononucleosis
D)Hodgkin's disease

Question 14

A peripheral blood picture dominated by mature lymphocytes that resemble nucleated red blood cells would most likely be seen in:

A)Sézary syndrome
B)Burkitt's lymphoma
C)CLL
D)Infectious mononucleosis

Question 15

All of the following describe characteristics of a plasma cell except:

A)Medium-sized cell
B)Eccentric nucleus
C)Well-defined Golgi apparatus
D)Very little, light blue cytoplasm

Question 16

A new treatment for multiple myeloma that was once banned from use in pregnant women is:

A)EPO
B)Thalidomide
C)Demerol
D)Interferon

Question 17

Hypogammaglobulinemia is a significant feature in half of patients with CLL.This complication can lead to:

A)Refractory anemia
B)Essential thrombocytosis
C)Autoimmune hemolytic anemia
D)Pernicious anemia

Question 18

Which of the following statements about Hodgkin's disease is false?

A)The peak incidence for the disease is 15 to 40 years of age.
B)The disease occurs more frequently in males.
C)It is a precursor to T-cell lymphoma
D)Individuals who have been exposed to the Epstein-Barr virus may be more vulnerable to Hodgkin's lymphoma.