Deck 10: Abnormalities of White Cells: Quantitative, Qualitative, and the Lipid Storage Diseases

Question 1

Pelger-Huët anomaly is characterized mainly by:

A)Neutrophils with gray-green granules
B)Lipid depositions in the cytoplasm
C)Giant platelets
D)Hyposegmentation of the nucleus in the neutrophils

Answer 1

D

Question 2

All of the following are lipid storage syndromes/diseases except:

A)Gaucher's disease
B)Tay-Sachs disease
C)Chediak-Higashi syndrome
D)Niemann-Pick disease

Answer 2

C

Question 3

Infectious mononucleosis is caused by the EBV virus, which infects B lymphocytes.

Answer 3

True

Question 4

In which white blood cell disorder will you see prominent deposition of granules in every cell line?

A)May-Hegglin anomaly
B)Alder's anomaly
C)Pelger-Huët anomaly
D)Chediak-Higashi syndrome

Question 5

In which white blood cell disorder will you see gray-green cytoplasmic granules in the neutrophils?

A)May-Hegglin anomaly
B)Alder's anomaly
C)Pelger-Huët anomaly
D)Chediak-Higashi syndrome

Question 6

A typical blood picture in infectious mononucleosis is an absolute:

A)Lymphocytosis and anemia with many reactive lymphocytes
B)Lymphocytosis without anemia and many reactive lymphocytes
C)Monocytosis and anemia with many atypical monocytes
D)Monocytosis without anemia and many atypical monocytes

Question 7

The best corrective action for a patient who exhibits platelet satellitism on peripheral blood smear is to:

A)Make a duplicate slide and see if this phenomenon disappears
B)Warm the tube of blood
C)Redraw the sample in sodium citrate
D)Vortex the sample of blood

Question 8

HIV inverses the normal ratio of CD4 to CD8 lymphocytes, which is:

A)1:2
B)1:1
C)2:1
D)4:1

Question 9

Opsonization of foreign bodies is defined as:

A)Preparing a foreign body for phagocytosis
B)Degranulation of neutrophils
C)Fusion of cytoplasmic granules
D)Bacteriocidal activity

Question 10

All of the following are mechanisms by which neutropenia is usually produced except:

A)Decreased production by the bone marrow
B)Impaired release from the bone marrow to the blood
C)Increased destruction
D)Bacterial infection

Question 11

Toxic granulation in neutrophils is a direct result of:

A)Cytokine production
B)Enhanced lysosome enzyme production
C)Toxic granulation
D)Ehrlichia infection

Question 12

Toxic vacuolization occurs most frequently in:

A)Neutrophils
B)Monocytes
C)Lymphocytes
D)Erythrocytes

Question 13

Döhle bodies consist of:

A)DNA
B)Primary granules
C)Ribosomes RNA
D)Lipid deposits

Question 14

A patient who presents with a low white cell count, thrombocytopenia, elevated liver enzymes, and mulberry-like inclusions in the granulocytes is most likely suffering from:

A)May-Hegglin anomaly
B)Chediak-Higashi anomaly
C)Human ehrlichiosis
D)Alder's anomaly

Question 15

Which of the following is an unusual complication that may occur in infectious mononucleosis?

A)Splenic infarctions
B)Dactylitis
C)Hemolytic anemia
D)Giant platelets

Question 16

A patient with bacteremia will have an increase in lymphocytes.

Question 17

Which of the following statements is common to most lipid storage diseases?

A)They are caused by an amino acid substitution.
B)They are caused by a DNA synthetic defect.
C)They are caused by a missing metabolic enzyme.
D)They are caused by the invasion of a rickettsial organism.

Question 18

A patient who has a persist leukocytosis, Döhle bodies, and an elevated LAP score most likely has a(n):

A)Leukemoid reaction
B)Pelger-Huët anomaly
C)Parasitic infection
D)HIV infection

Question 19

A 17-year-old boy is admitted to the hospital with a fever of unknown origin.His WBC count is 20.0 $\times$ 10⁹/L.All of the following can be seen on his peripheral smear except:

A)Toxic granulation
B)Reactive monocytes
C)Increased band neutrophils
D)Döhle bodies

Question 20

An autosomal disorder that manifests itself with large lysosomal inclusions, recurring infections, and albinism is:

A)Chediak-Higashi
B)Pelger-Huët
C)May-Hegglin
D)Alder-Reilly