Deck 3: Immunity

Question 1

Which of the following is a condition that involves a deficiency in number, function, or interrelationships of the involved white blood cells and their products?

A) Autoimmune disease
B) Leukocytosis
C) Immunodeficiency
D) Anaphylaxis

Answer 1

Immunodeficiency

Question 2

Wickham striae is a term used to describe the oral mucosal lesions of:

A) linea alba.
B) frictional keratosis.
C) lichen planus.
D) erythema multiforme.

Answer 2

lichen planus.

Question 3

An example of natural passive immunity would occur when:

A) antibodies from a mother pass through the placenta to the developing fetus.
B) a microorganism causes a disease.
C) a person receives a vaccination.
D) a person is immunized.

Answer 3

antibodies from a mother pass through the placenta to the developing fetus.

Question 4

In which type of immune response do B lymphocytes and antibodies play the predominant role?

A) Cell-mediated immunity
B) Immune complex
C) Humoral immunity
D) Passive immunity

Question 5

What is the most common precipitating factor in the development of aphthous ulcers?

A) Allergy
B) Trauma
C) Systemic disease
D) Citrus foods

Question 6

Which lymphocyte matures without passing through the thymus and later can develop into a plasma cell that produces antibodies?

A) T lymphocyte
B) B lymphocyte
C) Macrophage
D) LE cell

Question 7

An antigenic marker called HLA-B27 is present in most patients with:

A) lichen planus.
B) Reiter syndrome.
C) erythema multiforme.
D) Stevens-Johnson syndrome.

Question 8

Which one of the following is not a specific component of immunity?

A) A humoral response
B) A cell-mediated response
C) Memory
D) Pavementing

Question 9

Which one of the following is an example of type I hypersensitivity?

A) Immune complexes formed between microorganisms and antibody in the circulating blood
B) Asthma
C) Autoimmune hemolytic anemia
D) Serum sickness

Question 10

Which one of the following has not been associated with erythema multiforme?

A) Herpes simplex
B) Histoplasmosis
C) Tuberculosis
D) HLA-B27

Question 11

These recurrent ulcers appear on movable mucosa. They are discrete, round-to-oval ulcers that are 3 to 5 mm in diameter and exhibit a yellowish-white fibrin center surrounded by an erythematous halo.

A) Major aphthous ulcers
B) Sutton disease
C) Herpetiform aphthous ulcers
D) Minor aphthous ulcers

Question 12

The diagnosis of lichen planus is made on the basis of:

A) clinical and radiographic appearance.
B) clinical and histologic appearance.
C) history of the condition.
D) therapeutic medication.

Question 13

Which of the following is a protein molecule that is produced plasma cells and also called an immunoglobulin?

A) An autoimmune disease
B) A natural killer cell
C) Rheumatoid factor
D) An antibody

Question 14

Which one of the following is not a component of Reiter syndrome?

A) Arthritis
B) Geographic tonguelike lesions
C) Urethritis
D) Wickham striae

Question 15

Antihistaminic drugs are the principal method of treatment for:

A) urticaria.
B) minor aphthous ulcers.
C) herpetiform aphthous ulcers.
D) contact mucositis.

Question 16

Which one of the following ulcers may require a biopsy to make the diagnosis?

A) Minor aphthous ulcers
B) Major aphthous ulcers
C) Herpetiform aphthous ulcers
D) Behçet syndrome

Question 17

Which one of the following routes of drug administration can cause the most significant hypersensitivity reaction?

A) Topical
B) Patch
C) Parenteral
D) Oral

Question 18

The breakdown of cellular adhesion between epithelial cells is called:

A) cell-mediated immunity.
B) acantholysis.
C) Nikolsky sign.
D) anaphylaxis.

Question 19

A prodromal period occurs:

A) 1 week before onset of the ulcers.
B) 1 to 2 days before onset.
C) the day the ulcers erupt.
D) 7 to 10 days before the ulcers erupt.

Question 20

This condition, thought to be a hypersensitivity reaction, is characterized by skin and mucous membrane lesions. The skin lesions are referred to as target, iris, or bull's eye lesions. The lips and mucosal lesions are more extensive and painful and often appear bloody and crusted. The intraoral lesions are extensive superficial ulcerations. The onset is explosive. On the basis of these clinical features you suspect:

A) erythema multiforme.
B) fixed drug reaction.
C) Beçhet syndrome.
D) angioedema.

Question 21

Treatment for pemphigus vulgaris involves:

A) high doses of systemic corticosteroids.
B) antihistamines.
C) antibiotics.
D) antiviral drugs.

Question 22

The diagnosis for cicatricial pemphigoid is made by:

A) clinical appearance of the lesions.
B) Nikolsky sign.
C) biopsy and histologic examination.
D) response to corticosteroids.

Question 23

The most common oral site for cicatricial pemphigoid is the:

A) floor of the mouth.
B) gingiva.
C) palate.
D) tongue.

Question 24

The most characteristic skin lesion in SLE is described as:

A) a blister.
B) urticaria.
C) a butterfly rash.
D) a bulla.

Question 25

Sjögren syndrome is:

A) an autoimmune disease that affects the salivary and lacrimal glands.
B) an allergic reaction.
C) a form of aphthous ulcers.
D) a type of Langerhans cell disease.

Question 26

Diagnosis of systemic lupus erythematosus (SLE) is made on the basis of:

A) skin lesions.
B) multiorgan involvement and antinuclear antibodies in the serum.
C) arthritis and arthralgia.
D) shortness of breath.

Question 27

The classic appearance of this condition is a patterrn of interconnecting slender lines referred to as Wickham striae.

A) Lichen planus
B) Linea alba
C) Erythema multiforme
D) Reiter syndrome

Question 28

Pemphigus vulgaris differs histologically from cicatricial pemphigoid in that pemphigus vulgaris has:

A) degeneration of the epithelium.
B) connective tissue fragmentation.
C) significant inflammatory cells.
D) scarring.

Question 29

The onset of this condition is explosive. It is characterized by skin and mucosal lesions. The skin lesions are referred to as target, iris, or bull's eye lesions. The mucosal lesions affect the buccal mucosa, lips, and tongue and appear as superficial ulcerations. The lip lesions are ulcerated, encrusted, and bloody. On the basis of this description, you suspect:

A) lichen planus.
B) erythema multiforme.
C) contact dermatitis.
D) SLE.

Question 30

The eye damage that occurs in Sjögren syndrome is called:

A) xeropthalmia.
B) keratoconjunctivitis sicca.
C) conjunctivitis.
D) burning eyes.

Question 31

The most common oral manifestation of Sjögren syndrome is:

A) xerostomia.
B) xeropthalmia.
C) epimyoepithelial islands.
D) aphthous ulcers.

Question 32

The histologic appearance of lesions in SLE may resemble:

A) an ulcer.
B) lichen planus.
C) pemphigus vulgaris.
D) erythema multiforme.

Question 33

The acute disseminated form of Langerhans cell disease is called:

A) eosinophilic granuloma.
B) Hand-Schüller-Christian disease.
C) Letterer-Siwe disease.
D) Reiter syndrome.

Question 34

In which one of the following is the Langerhans cell not the proliferating cell?

A) Lichen planus
B) Letterer-Siwe disease
C) Hand-Schüller-Christian disease
D) Eosinophilic granuloma

Question 35

The diagnosis of Behçet syndrome requires which of the following?

A) Two of the three principal manifestations
B) Presence of all three manifestations
C) A biopsy
D) A history of pemphigus vulgaris

Question 36

This form of Langerhans cell disease resembles lymphoma, affects children under three, and has a rapid fatal course.

A) Letterer-Siwe disease
B) Hand-Schüller-Christian disease
C) Eosinophilic granuloma
D) Chronic localized form

Question 37

Primary Sjögren syndrome occurs when:

A) another autoimmune disease accompanies salivary and lacrimal gland involvement.
B) there is only salivary and lacrimal gland involvement without the presence of another autoimmune disease.
C) rheumatoid arthritis is present.
D) Raynaud phenomenon is present.

Question 38

This patient has Sjögren syndrome and severe xerostomia. Which of the following is the clinical feature that most appropriately describes the changes on the tongue in this patient?

A) Dryness
B) Candidiasis
C) Loss of filiform and fungiform papillae
D) Fissures

Question 39

The classic triad of symptoms seen in 25% of patients with Hand-Schüller-Christian disease includes all of the following except:

A) well-defined or punched-out radiolucent areas in the skull.
B) exopthalmous.
C) cyclic neutropenia.
D) diabetes insipidus.

Question 40

Which one of the following is not a characteristic feature of pemphigus vulgaris?

A) Epithelial acantholysis
B) Bullae
C) Tzanck cells
D) Most common in females