Deck 11: Autoimmunityorgan or Tissue Specific

Question 1

What should you test to determine the diagnosis of the student in question 1?
a.IgA against tissue transglutaminase
b.autoantibodies targeting the adrenal cortex
c.antibody to thyroid hormone-stimulating receptor, triiodothyronine and thyroxine (T3 and T4), levels
d.triiodothyronine and thyroxine (T3 and T 4) levels and antibodies to thyroglobulin and thyroperoxidase

Answer 1

triiodothyronine and thyroxine (T3 and T 4) levels and antibodies to thyroglobulin and thyroperoxidase

Question 2

Autoantibodies against sperm
a.are found bound to the sperm in a binding assay with latex beads that have anti-IgG on their surface
b.are found bound to the sperm in a binding assay with latex beads that have anti-IgA on their surface
c.A and B
d.none of the above

Answer 2

A and B

Question 3

Cortisol and aldosterone insufficiency develop in which of the following diseases?
a.Grave's disease
b.Hashimoto's disease
c.Addison's disease
d.celiac disease

Answer 3

Addison's disease

Question 4

The disease in question 15 is
a.multiple sclerosis
b.Addison's disease
c.Grave's disease
d.myasthenia gravis
e.type 1 diabetes

Question 5

Antibodies to acetylcholine and T-cell reactivity are seen in which of the following?
a.a type I and a type II disease
b.a type II and a type III disease
c.a type IV and a type I disease
d.a type IV and a type II disease

Question 6

A student in the class always is complaining that she's cold, she's tired, she's been gaining weight but says she just doesn't care about anything anymore. The semester has been tough, and although you feel guilty, at first you ignore her, but just now as you looked up, her neck appears to be enlarged in the front and her skin and hair look dry. What do you think she might have?
a.Grave's disease
b.Hashimoto's disease
c.Addison's disease
d.Celiac disease

Question 7

What should you look for to determine the diagnosis of the student in question 9?
a.IgA against tissue transglutaminase
b.autoantibodies targeting the adrenal cortex
c.antibody to thyroid hormone-stimulating receptor, thyroxine (T3 and T4) levels
d.triiodothyronine and thyroxine (T3 and T 4) levels and antibodies to thyroglobulin and thyroperoxidase

Question 8

Antibodies found in type 1 insulin-dependent diabetes include
a.glutamic acid decarboxylase-65 (GAD-65), insulin-associated antigen, and insulin
b.catecholamines, desmoglein, and insulin
c.transglutaminase, insulin and insulin-associated antigen
d.myelin basic protein, transglutaminase, and insulin

Question 9

Venous and arterial clots are associated with
a.anti-CCP
b.rheumatoid factor
c.antiphospholipid antibody
d.A and B
e.B and C

Question 10

How should the patient in questions 9 and 10 be treated?
a.placed on a gluten-free diet
b.given thyroid hormone replacement therapy
c.treat the symptoms, which sometimes resolves the situation
d.given replacement therapy with glucocorticoids and mineralocorticoids

Question 11

Another student has an odd-looking blistery rash and has been losing weight. You and she are good friends, but must she tell you about her bowel symptoms? She has diarrhea and cramping. What do you think she might have?
a.Grave's disease
b.Hashimoto's disease
c.Addison's disease
d.Celiac disease

Question 12

ANCA
a.stands for antinuclear and cytoplasmic antibodies
b.stands for antineutrophil cytoplasmic antigens
c.aids in the diagnosis of vasculitic diseases
d.A and C
e.B and C

Question 13

What should you look for to determine the diagnosis in your grandmother in question 12?
a.IgA against tissue transglutaminase
b.antidesmoglein antibodies by direct immunofluorescence of a skin biopsy near the blisters
c.BP180 and BP230 antibodies by direct immunofluorescence of a skin biopsy near the blisters
d.antibodies to acetylcholine by EIA of her serum

Question 14

How should your grandmother in questions 12 and 13 be treated?
a.as a burn victim: giving her fluids, watching for sepsis, and then giving systemic corticosteroids
b.removing gluten from her diet
c.treating with systemic corticosteroids
d.treating the vitamin D deficiency, and the lesions should resolve

Question 15

Your grandmother has blisters in her mouth. At first you thought that they are just canker sores, but now they have spread to her scalp! She has always been so proud of her looks and is upset. These are huge blisters, bigger than 1 cm in diameter, and they burst easily. In making a diagnosis, for what should her physician look?
a.a skin biopsy by direct immunofluorescence
b.indirect enzyme immunoassay
c.a skin biopsy by indirect immunofluorescence
d.A or B
e.A or C

Question 16

Dry eyes and mouth are symptoms of which of the following diseases?
a.scleroderma
b.myasthenia gravis
c.Sjögren's syndrome
d.systemic sclerosis

Question 17

ANCA is found in
a.type 1 diabetes
b.Hashimoto's disease
c.SLE
d.Wegener's granulomatosis

Question 18

How should the patient in question 1 be treated?
a.placed on a gluten-free diet
b.given thyroid hormone replacement therapy
c.treat the symptoms, which sometimes resolves the situation
d.given replacement therapy with glucocorticoids and mineralocorticoids

Question 19

Antibodies to glutamic acid decarboxylase-65, insulin-associated antigen, and insulin found are found in which of the following diseases?
a.celiac
b.Crohn's
c.type 1 diabetes mellitus
d.Addison's

Question 20

Of two different autoimmune diseases of the thyroid gland occur that give different symptoms, which of the following is consistent with the symptoms seem in each disease?
a.Hashimoto's diseases: is hot, needs little sleep, has dry skin, has lost weight; Grave's: is cold, is tired, has gained weight
b.Hashimoto's disease: is cold, needs little sleep, has dry skin, has gained weight; Grave's: is hot, is tired, has lost weight
c.Hashimoto's diseases: is cold, is tired, has dry skin, has gained weight; Grave's: is hot, needs little sleep, has lost weight
d.Hashimoto's diseases: is hot, needs little sleep, has dry skin, has lost weight; Grave's: is cold, is tired, has gained weight

Question 21

Antibody-mediated destruction of the acetylcholine receptor at the postsynaptic membrane of the neuromuscular junction occurs in which of the following diseases?
a.multiple sclerosis
b.Addison's
c.biliary cirrhosis
d.myasthenia gravis

Question 22

Detection of 21-hydroxylase autoantibodies occurs in which of the following diseases?
a.celiac
b.Crohn's
c.type 1 diabetes mellitus
d.Addison's

Question 23

Antibodies against the yeast species Saccharomyces cervesiae are found in which of the following diseases?
a.celiac
b.Crohn's
c.autoimmune hepatitis
d.Addison's

Question 24

Which of the following diseases is strongly related to celiac disease?
a.pemphigus vulgarus
b.dermatitis herpetiformis
c.bullous pemphigoid
d.basal cell carcinoma

Question 25

IgA autoantibodies against gliadin, tissue transglutaminase, and endomysium are found in patients which of the following diseases?
a.celiac
b.Crohn's
c.type 1 diabetes mellitus
d.Addison's