Question 1

Which of the following decides the choice of delivery system for antimicrobials/antibiotics?&#10;A)Target site&#10;B)Degree of absorption&#10;C)Severity of side effects&#10;D)Amount of drug administered

Accepted Answer

The choice of delivery system for antimicrobials/antibiotics is primarily decided by the target site of the infection. Different delivery systems such as oral, intravenous, intramuscular, topical, etc. are selected based on the location of the infection and the required concentration of the drug at that site. Therefore, option A, target site, is the best choice. The degree of absorption, severity of side effects, and amount of drug administered can also influence the choice of delivery system, but they are secondary factors compared to the target site.

Question 2

Which of the following antibiotics is especially indicated for refractory periodontitis?&#10;A)Clindamycin&#10;B)Erythromycin&#10;C)Metronidazole&#10;D)Amoxicillin&#10;E)Tetracycline

Accepted Answer

Clindamycin

Question 3

Which of the following antibiotics is most effective against strict anaerobes such as Porphyromonas gingivalis?&#10;A)Metronidazole&#10;B)Tetracycline&#10;C)Doxycycline&#10;D)Clindamycin

Accepted Answer

Metronidazole is a synthetic nitroimidazole antibiotic that is effective against strict anaerobes such as Porphyromonas gingivalis. It works by disrupting the DNA synthesis pathway in the bacteria, leading to cell death. Tetracycline and doxycycline are broad-spectrum antibiotics that are effective against many types of bacteria but may not be as effective against strict anaerobes. Clindamycin is also effective against strict anaerobes but has a higher risk of causing serious side effects such as C. difficile-associated diarrhea. Therefore, the best choice for treating strict anaerobic infections like periodontitis caused by Porphyromonas gingivalis is metronidazole.

Question 4

All of the following statements are true about doxycycline 20 mg except one. Which one is the exception?&#10;A)It is an antibiotic.&#10;B)It has no antibacterial action.&#10;C)It inhibits collagenase production and release from host cells.&#10;D)It is effectively used for nine months.&#10;E)It is used in periodontics and dermatology.

Accepted Answer

Doxycycline 20 mg is not used as an antibiotic at this low dose; it is used for its anti-collagenase properties, hence it has no antibacterial action.

Question 5

Which of the following drugs is highly concentrated in the gingival crevicular fluid (GCF)?&#10;A)Tetracycline&#10;B)Amoxicillin&#10;C)Clindamycin&#10;D)Erythromycin&#10;E)Penicillin VK

Accepted Answer

Tetracycline is highly concentrated in the gingival crevicular fluid, making it a good choice for treating periodontal infections.

Question 6

Which of the following drugs is found in Arestin?&#10;A)Doxycycline hyclate&#10;B)Minocycline HCl&#10;C)Tetracycline HCl&#10;D)Azithromycin HCl&#10;E)Clindamycin HCl

Accepted Answer

Arestin contains minocycline HCl, which is a tetracycline antibiotic used for the treatment of periodontal disease.

Question 7

Which of the following ingredients is contained in Atridox?&#10;A)Chlorhexidine&#10;B)Doxycycline&#10;C)Minocycline&#10;D)Amoxicillin

Accepted Answer

Atridox contains doxycycline, which is an antibiotic used to treat periodontitis. Chlorhexidine and minocycline are also used to treat periodontitis, but they are not present in Atridox. Amoxicillin is an antibiotic used to treat other types of infections and is not used for periodontitis.

Question 8

Which of the following antibiotics is contraindicated during pregnancy and in children up to age 8?&#10;A)Erythromycin sterate&#10;B)Clindamycin HCl&#10;C)Cephalosporin&#10;D)Amoxicillin&#10;E)Tetracycline HCl

Accepted Answer

Tetracycline HCl is contraindicated during pregnancy and in children up to age 8 because it can cause permanent discoloration of developing teeth and may also affect bone growth. The other antibiotics listed are generally safe for use in pregnancy and children.

Question 9

Which of the following antibiotics is indicated in generalized chronic periodontitis?&#10;A)Quinolone&#10;B)Azithromycin&#10;C)Amoxicillin&#10;D)None

Accepted Answer

Antibiotics are not routinely recommended for generalized chronic periodontitis unless there is a specific indication (such as systemic involvement or refractory disease). Instead, the primary treatment for chronic periodontitis is mechanical removal of subgingival bacteria through scaling and root planing.

Question 10

The development of pseudomembranous colitis is associated with the growth of&#10;A)Prevotella intermedia.&#10;B)Porphyromonas gingivalis.&#10;C)Clostridium difficle.&#10;D)Treponema denticola.

Accepted Answer

Pseudomembranous colitis is specifically associated with the growth of Clostridium difficile, an anaerobic, spore-forming bacterium that can colonize the large intestine and cause severe inflammation, diarrhea, and even perforation of the colon. None of the other bacterial species listed have been implicated in the development of pseudomembranous colitis.

Question 11

To which of the following delivery systems do Arestin and Atridox belong?&#10;A)Topical&#10;B)Local&#10;C)Systemic&#10;D)Rinse

Accepted Answer

The answer of To which of the following delivery systems...

Question 12

Which of the following antibiotics should not be taken with alcohol?&#10;A)Penicillin&#10;B)Erythromycin&#10;C)Metronidazole&#10;D)Azithromycin&#10;E)Clindamycin

Accepted Answer

The answer of Which of the following antibiotics should not...

Question 13

For which of the following conditions are systemic antibiotics indicated?&#10;A)Gingivitis&#10;B)Generalized chronic periodontitis&#10;C)Localized chronic periodontitis&#10;D)Localized aggressive periodontitis

Accepted Answer

The answer of For which of the following conditions are...

Question 14

In which of the following situations is doxycycline 20 mg indicated?&#10;A)Chronic gingivitis&#10;B)Necrotizing ulcerative periodontitis&#10;C)Localized aggressive periodontitis&#10;D)Generalized aggressive periodontitis&#10;E)Generalized chronic periodontitis

Accepted Answer

The answer of In which of the following situations is...

Question 15

Which of the following antibiotics concentrates in phagocytes such as PMNs within the inflamed connective tissue?&#10;A)Minocycline&#10;B)Doxycycline&#10;C)Amoxicillin&#10;D)Azithromycin&#10;E)Metronidazole

Accepted Answer

The answer of Which of the following antibiotics concentrates in...

Question 16

Which of the following combination antibiotics is typically used in patients with localized aggressive periodontitis?&#10;A)Amoxicillin + tetracycline&#10;B)Metronidazole + amoxicillin&#10;C)Tetracycline + doxycycline&#10;D)Erythromycin + azithromycin&#10;E)Clindamycin + erythromycin

Accepted Answer

The answer of Which of the following combination antibiotics is...

Question 17

Which of the following antibiotics is classified as a second-generation macrolide?&#10;A)Penicillin&#10;B)Erythromycin&#10;C)Metronidazole&#10;D)Azithromycin&#10;E)Clindamycin

Accepted Answer

The answer of Which of the following antibiotics is classified...

Question 18

Which of the following antibiotics forms a complex with calcium during enamel formation?&#10;A)Erythromycin&#10;B)Amoxicillin&#10;C)Ampicillin&#10;D)Metronidazole&#10;E)Doxycycline

Accepted Answer

The answer of Which of the following antibiotics forms a...

Question 19

In which of the following structures is Atridox placed?&#10;A)Periodontal pocket&#10;B)Maxillary sinus&#10;C)Alveolar bone&#10;D)Connective tissue

Accepted Answer

The answer of In which of the following structures is...

Question 20

Which of the following ingredients is contained in PerioChip?&#10;A)Chlorhexidine&#10;B)Doxycycline&#10;C)Minocycline&#10;D)Amoxicillin

Accepted Answer

The answer of Which of the following ingredients is contained...

Question 21

Doxycycline has both antibacterial and ________ properties.

Accepted Answer

The answer of Doxycycline has both antibacterial and ________ properties....

Question 22

Discuss the indications for systemic antibiotic usage in periodontics.

Accepted Answer

The answer of Discuss the indications for systemic antibiotic usage...

Question 23

Doxycycline 20 mg is dispensed as a ________.

Accepted Answer

The answer of Doxycycline 20 mg is dispensed as a...

Question 24

Doxycycline 20 mg inhibits enzymes produced and secreted by ________ in the host body.

Accepted Answer

The answer of Doxycycline 20 mg inhibits enzymes produced and...

Question 25

Arestin is a powder form of ________.

Accepted Answer

The answer of Arestin is a powder form of ________....

Question 26

Why is periodontal debridement (scaling and root planing)necessary before any form of antimicrobial or antibiotic is administered?

Accepted Answer

The answer of Why is periodontal debridement (scaling and root...

Question 27

Atridox is a gel form of ________ hyclate.

Accepted Answer

The answer of Atridox is a gel form of ________...

Deck 20: Systemic and Local Drug Delivery Systems: Systemic Antibiotics, Local Drug Devices, and Enzyme Suppression Therapy