Question 1

Imatinib (Gleevec) is indicated as treatment for which type of cancer?&#10;A)Chronic myeloid leukemia&#10;B)Acute lymphocytic leukemia&#10;C)Chronic lymphocytic leukemia&#10;D)Acute myeloid leukemia

Accepted Answer

Imatinib is indicated for the treatment of chronic myeloid leukemia (CML),particularly after failure of interferon alfa therapy.Imatinib is one of the newest available antineoplastic drugs.

Question 2

Large,cumulative doses of doxorubicin (Adriamycin),a cytotoxic antibiotic,are known to cause which adverse effect?&#10;A)Severe emesis&#10;B)Cardiomyopathy&#10;C)Lung disease&#10;D)Nephrotoxicity

Accepted Answer

Severe cases of cardiomyopathy are associated with large,cumulative doses of doxorubicin.Routine monitoring of cardiac ejection fraction is needed.

Question 3

Patients receiving antineoplastic drugs should be advised to take which medication for minor aches and pains?&#10;A)ibuprofen&#10;B)acetylsalicylic acid&#10;C)acetaminophen&#10;D)naproxen

Accepted Answer

Acetaminophen,which has no effect on bleeding.Patients receiving chemotherapy drugs should avoid nonsteroidal anti-inflammatory drugs such as ibuprofen,acetylsalicylic acid,and naproxen,due to the increased risk of bleeding.

Question 4

Alkylating drugs can have a profound effect on the patient's nutritional status.Which laboratory result will assist the nurse in determining the impact the drug has had on the patient's nutritional status?

A)White blood cell (WBC) count
B)Platelet count
C)Alanine aminotransferase (ALT) levels
D)Serum albumin levels

Accepted Answer

Serum levels of albumin and protein should be noted,as should fluid and electrolyte levels.

Question 5

Which is an adverse effect of estrogen receptor antagonists?&#10;A)Constipation and urinary changes&#10;B)Confusion and tachycardia&#10;C)Hot flashes and pharyngitis&#10;D)Weakness and hypoventilation

Accepted Answer

Adverse effects of estrogen receptor antagonists include vasodilation,pain,headache,hot flushes,nausea,vomiting,and pharyngitis.

Question 6

A patient is receiving bicalutamide.Which nursing diagnosis is appropriate for this hormonal antineoplastic drug?&#10;A)Ineffective tissue perfusion related to cardiotoxicity&#10;B)Disturbed sensory perception related to ototoxicity&#10;C)Activity intolerance related to anemia-induced fatigue&#10;D)Impaired urinary elimination pattern related to hyperuricemia

Accepted Answer

Activity intolerance related to anemia is causing fatigue.Other adverse effects include peripheral edema,pain,hot flushes,gynecomastia,nausea,and diarrhea.

Question 7

A patient is receiving alkylating drugs.Which signs may indicate an oncological emergency?&#10;A)Cracked lips&#10;B)Temperature of 38.8&#176;C&#10;C)Diarrhea&#10;D)Dry cough

Accepted Answer

Fever and chills with a temperature of 38.1°C or higher indicate an oncological emergency,and the physician should be contacted immediately.The physician should also be contacted immediately in the case of sores or cracks in the mouth,diarrhea that lasts more than 2 or 3 days,and a persistent cough.

Deck 53: Antineoplastic Drugs Part 2: Cell Cycle–Nonspecific and Miscellaneous Drugs