Deck 4: Radiochemistryradiopharmacology

Question 1

Prerelease testing for each batch of ¹⁸F-FDG should include

A) determination of aluminum concentration.
B) titration testing.
C) identity testing.
D) lipophilic testing.

Answer 1

identity testing.

Question 2

A concentration of aluminum of 15 $\mu$ g/ml in the preparation of a ^99mTc-labeled radiopharmaceutical

A) would have no affect on a scan.
B) could result in liver uptake.
C) is within the NRC limits.
D) is necessary for proper tagging.

Answer 2

could result in liver uptake.

Question 3

Gallium-67 is an example of a radionuclide that is

A) generator produced.
B) reactor produced.
C) cyclotron produced.
D) byproduct material.

Answer 3

reactor produced.

Question 4

If the N/P ratio is too low for stability, radioactive decay is accomplished through either

A) positron emission or electron capture.
B) negative beta particle production or electron capture.
C) positron or Auger electron emission.
D) production of a negative or positive beta particle.

Question 5

Bacterial endotoxin testing (BET) is used for

A) sterility testing.
B) chemical impurity testing.
C) pyrogen testing.
D) determining expiration dates on kits.

Question 6

In the resting state, the maximum concentration of ²⁰¹Tl in the heart occurs approximately

A) 5 to 9 minutes after injection.
B) 10 to 30 minutes after injection.
C) 40 to 60 minutes after injection.
D) 100 to 120 minutes after injection.

Question 7

Annihilation radiation is characteristic of

A) electron capture.
B) position decay.
C) negative beta decay.
D) isometric transition.

Question 8

The consequence of a neutron-rich nucleus is

A) an Auger electron.
B) electron capture.
C) production of positron emission.
D) production of negative beta particle.

Question 9

In studies using ^99mTcO₄^-, patients are often pretreated with a(n)

A) iodine solution.
B) sodium solution.
C) potassium iodide solution.
D) sodium iodide solution.

Question 10

When compared to the wet column ⁹⁹Mo-^99mTc generator, the dry column ⁹⁹Mo-^99mTc generator has

A) a better elution yield due to decreased radiolysis products.
B) a poorer elution yield due to decreased radiolysis products.
C) a better elution yield due to increased radiolysis products.
D) a poorer elution yield due to increased radiolysis products.

Question 11

The ⁹⁹Mo-^99mTc generator is an example of

A) a transient equilibrium system.
B) the separation of fission products.
C) a secular equilibrium system.
D) an accelerator product.

Question 12

Hepatocyte function can be imagined using

A) (^99mTc-sulfur colloid.)
B)(^99mTcO₄^-.)
C) (^99mTc-disofenin.)
D)(^99mTcO₄^--tagged red blood cells.)

Question 13

Radionuclides used to label radiopharmaceuticals for nuclear imaging should decay by

A) alpha or negative beta.
B) negative beta or positron.
C) positron or gamma.
D) gamma or auger electron.

Question 14

Dipyridamole is administered to a patient as part of a pharmacological stress test. The patient has an onset of angina pectoris. To reverse this adverse reaction of the dipyridamole, the patient is given

A) morphine.
B) aminophylline.
C) atropine.
D) nitroglycerin.

Question 15

When labeling red blood cells using the in vitro method, acid-citrate-dextrose (ACD) is added to the aliquot of patient's blood to

A) "thin" the blood.
B) reduce any extracellular stannous chloride.
C) prevent clotting.
D) stop the tagging.

Question 16

When using radiochromatography to evaluate the percentage of radiochemical purity in the reduced soluble ^99mTc radiopharmaceuticals, the technologist checks for the percentages of

A) free pertechnetate, hydrolized technetium, and labeled radiopharmaceutical.
B) hydrolyzed technetium and free pertechnetate.
C) free pertechnetate and bound radiopharmaceutical.
D) reduced hydrolyzed ^99mTc and lipophilic impurities.

Question 17

After elution of the generator, the concentration of ⁹⁹Mo found in the ^99mTc is 0.10 µCi/mCi of ^99mTc. The technologist should

A) not use the (^99mTc) and reelute the generator.
B) not use the (^99mTc) and wait 6 hours before reeluting the generator.
C) use the (^99mTc) as usual to make the kits.
D) use instant thin-layer chromatography (ITLC).

Question 18

Specific activity is defined as the

A) activity of a radioactive isotope per gram of that same element.
B) amount of radioactive isotope in a patient dose.
C) percentage of carrier-free radioisotope activity in its production.
D) percentage of stable isotope activity within a radioisotope.

Question 19

It is expected in a normal patient who is injected with ^99mTc-sulfur colloid (SC) that

A) 85% will localize in the liver and the remainder is sequestered by the spleen and bone marrow.
B) 85% will localize in the spleen and bone marrow and the remainder is sequestered by the liver.
C) 85% will localize in the lungs and the remainder is sequestered by liver, spleen, and bone marrow.
D) 85% will localize in the liver, spleen, and bone marrow and the remainder is eliminated via bowel.

Question 20

The ¹¹³Sn-^118mIn generator is an example of

A) a transient equilibrium system.
B) the separation of fission products.
C) a secular equilibrium system.
D) an accelerator product.

Question 21

A patient is having a reaction to adenosine. The technologist should ensure the availability of a dose of

A) nitroglycerin.
B) aminophylline.
C) morphine.
D) nothing; it has rapid reversal.

Question 22

A patient is having a reaction during dipyridamole stress testing manifesting as bronchospasm. The technologist should ensure the availability of a dose of

A) nitroglycerin.
B) aminophylline.
C) morphine.
D) nothing; it has rapid reversal.

Question 23

A patient is having a reaction to regadenoson. The technologist should ensure the availability of a dose of

A) nitroglycerin.
B) aminophylline.
C) morphine.
D) nothing; it has rapid reversal.

Question 24

The most commonly used cyclotron-produced radiohalogen is

A) (¹²³I.)
B) (¹³¹I.)
C) (¹²⁵I.)
D) (¹²¹I.)

Question 25

All of the following are commonly used PET radionuclides, EXCEPT

A) (¹⁵O.)
B) (¹³N.)
C) (¹⁴C.)
D) (¹⁸F.)