Question 1

A child has a primary immunodeficiency and the parent asks the provider about vaccines. What will the provider tell this patient?&#10;A) Avoid all vaccines since immunizations can cause disease in this child&#10;B) Immunized with all recommended childhood vaccines to prevent serious disease&#10;C) Some vaccines are contraindicated in those with T-cell involvement only&#10;D) The child may need more vaccine boosters than other children

Accepted Answer

Some vaccines, particularly live attenuated vaccines, are contraindicated in children with T-cell immunodeficiencies due to the risk of causing disease.

Question 2

A 6-month-old infant is suspected of having an immune deficiency disorder. Which diagnostic tests may be included to evaluate this patient? (Select all that apply.)&#10;A) Blood, urine, sputum, and wound cultures&#10;B) Delayed-type hypersensitivity skin testing&#10;C) Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels&#10;D) Metabolic profiles&#10;E) Serum electrolytes

Accepted Answer

A, C, D

Question 3

A patient presents with recurrent pneumococcal pneumonia and exhibits prolonged bleeding, easy bruising, and eczema. Which immunodeficiency disorder is likely in this patient?&#10;A) DiGeorge syndrome&#10;B) Hyperimmunoglobulinemia E syndrome&#10;C) Severe combined immunodeficiency disease (SCID)&#10;D) Wiskott-Aldrich syndrome (WAS)

Accepted Answer

The symptoms of recurrent pneumonia, prolonged bleeding, easy bruising, and eczema are characteristic of Wiskott-Aldrich syndrome (WAS), which is a primary immunodeficiency disorder caused by a mutation in the WAS gene. This gene is involved in the proper functioning of immune cells, platelets, and the cytoskeleton. Patients with WAS have decreased platelet counts, impaired T and B cell function, and recurrent bacterial infections. DiGeorge syndrome is characterized by defects in T cell development, while hyperimmunoglobulinemia E syndrome is characterized by recurrent bacterial and fungal infections and elevated levels of IgE. Severe combined immunodeficiency disease (SCID) is a group of disorders that affect both T and B cell function, leading to severe immunodeficiency.

Deck 204: Immunodeficiency