Deck 20: Cytomegalovirus

Question 1

A fourfold rise in IgG antibody titer suggests but does not prove __________ CMV infection.

A)recent
B)latent
C)reactivated
D)chronic

Answer 1

recent

Question 2

The most common virus transmitted to the fetus is

A)malaria.
B)rubella.
C)hepatitis.
D)cytomegalovirus.

Answer 2

cytomegalovirus.

Question 3

Cells of tissues that can harbor CMV include

A)peripheral blood leukocytes.
B)transplanted tissues
C)prostate tissue.
D)Both A and B.

Answer 3

Both A and B.

Question 4

Antibodies to early antigens can be associated with

A)primary infection.
B)reactivated infection.
C)latent infection.
D)Either A or B.

Question 5

Cytomegalovirus (CMV) is ____________ worldwide.

A)epidemic
B)endemic
C)infrequently seen
D)rarely seen

Question 6

Match the three types of CMV infection associated with blood transfusion with their appropriate description.
Reinfection

A)CMV strain in the donor's blood that differs from the strain originally infecting the recipient
B)Seronegative recipient is transfused with blood from actively or latently infected donor
C)Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 7

Match the three types of CMV infection associated with blood transfusion with their appropriate description.
Primary infection

A)CMV strain in the donor's blood that differs from the strain originally infecting the recipient
B)Seronegative recipient is transfused with blood from actively or latently infected donor
C)Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 8

Match the three types of CMV infection associated with blood transfusion with their appropriate description.
Reactivated infection

A)CMV strain in the donor's blood that differs from the strain originally infecting the recipient
B)Seronegative recipient is transfused with blood from actively or latently infected donor
C)Seropositive recipient is transfused with blood from CMV antibody-positive or CMV antibody-negative donor

Question 9

All the herpesviruses are relatively large, enveloped ________ viruses.

A)DNA
B)RNA
C)retro
D)Both B and C.

Question 10

Herpesviruses all share the characteristic of being

A)rare viruses.
B)associated with bioterrorism agents.
C)cell-associated.
D)only found in the United States.

Question 11

Forms of transfusion-acquired cytomegalovirus (CMV) infection include all the following except

A)primary infection.
B)reactivated infection.
C)reinfection with a different strain.
D)latent infection.

Question 12

CMV infection in normal adults and children is

A)associated with CMV hepatitis as well.
B)asymptomatic in most patients.
C)occasionally a self-limited, mononucleosis-like syndrome.
D)All of the above.

Question 13

The blood product that can transmit cytomegalovirus (CMV) is

A)platelet concentration.
B)washed red blood cells (RBCs).
C)leukocyte (WBC) concentrates.
D)plasma.

Question 14

The preferred method for diagnosis of CMV infection is

A)culture of virus.
B)polymerase chain reaction (PCR).
C)latex agglutination.
D)Either A or B.

Question 15

Individuals with the greatest risk of developing CMV infection are

A)fetuses.
B)immunocompromised individuals.
C)persons older than 40 years.
D)Both A and B.

Question 16

A latent CMV infection is defined as

A)persistent infections characterized by periods of reactivation.
B)the presence of genetic information in an unexpressed state in the host cell.
C)a condition of a dynamic relationship between the virus and host.
D)All of the above.

Question 17

Patients with the highest risk of mortality from CMV are

A)fetuses.
B)immunocompromised individuals.
C)allograft transplant, seronegative patients who receive tissue from a seropositive donor.
D)All of the above.

Question 18

Cytomegalovirus (CMV) is related to

A)Epstein-Barr virus (EBV).
B)herpes simplex 1.
C)herpes simplex 2.
D)All of the above.

Question 19

The great majority of infections in allograft recipients:

A)are transmitted by a donated organ.
B)arise from the reactivation of the recipient's latent virus.
C)are transmitted through transfusion of packed red blood cells.
D)Both A and B.

Question 20

Match the infections with the appropriate immunoglobulin response.
Primary infection

A)IgG, but IgM response unknown
B)Specific IgM antibody response
C)IgG (no detectable IgM)

Question 21

Primary and recurrent maternal CMV infections cannot be transmitted in utero.

Question 22

Match the infections with the appropriate immunoglobulin response.
Reinfection with strain of CMV different from original strain

A)IgG, but IgM response unknown
B)Specific IgM antibody response
C)IgG (no detectable IgM)

Question 23

CMV serology is recommended for immunocompromised patients.

Question 24

The patient infected with cytomegalovirus has mononucleosis-like symptoms but exhibits a negative Epstein-Barr virus (EBV) test result.

Question 25

Acquired CMV infection is usually asymptomatic and can persist in the host as a chronic or latent infection.

Question 26

Congenital CMV infection is the most common intrauterine infection.

Question 27

Match the infections with the appropriate immunoglobulin response.
Reactivation of latent infection in seropositive IgG patient

A)IgG, but IgM response unknown
B)Specific IgM antibody response
C)IgG (no detectable IgM)