Deck 41: The Future Role of Genetics in Womens Health Research and Clinical Care

Question 1

Which of the following is one of the major HBOC cancer susceptibility genes?

A) SCN5A
B) MLH1
C) PMS1
D) BRCA1

Answer 1

D

Question 2

Women with MODY are often initially thought to have _____.

A) type 1 diabetes
B) gestational diabetes
C) Lynch syndrome
D) inflammatory bowel disease

Answer 2

B

Question 3

Men with HNPCC mutations are most likely to develop colon cancer, whereas women with HNPCC mutations are most likely to develop _____ cancer.

A) endometrial
B) cervical
C) ovarian
D) pancreatic

Answer 3

A

Question 4

Prophylactic oophorectomy decreases the risk of breast cancer by up to 50% if performed _____.

A) before the age of 40 and followed by hormone replacement
B) before the age of 40 and not followed by hormone replacement
C) before the age of 50 and followed by hormone replacement
D) before the age of 50 and not followed by hormone replacement

Question 5

Which statement about genetic screening for adverse pharmacologic reactions is correct?

A) It would ultimately increase the cost of drug development.
B) It would ultimately decrease the total number of drugs available for clinical use.
C) It would provide a rational basis for drug selection.
D) It would eliminate the need for drug-based treatment for most medical conditions.

Question 6

According to the Amsterdam criteria, women with _____ are more likely to have HNPCC.

A) an advanced age of diagnosis (older than 55)
B) left-sided colon cancer
C) no more than one close family member with HNPCC-related cancer
D) colon cancer with signet ring morphology

Question 7

BART testing is commonly performed as part of a standard HBOC screening.

Question 8

There are genetic differences in drug targets that may differentiate responders from nonresponders.

Question 9

Arrhythmias in people with LQT2 are commonly induced by exercise.

Question 10

Studies using common genetic variants of modest risk have failed to predict risk of diabetes any better than routine clinical risk factors currently in practice.

Question 11

It is likely that chromosome microarrays will soon supplant the karyotype for invasive prenatal testing for chromosomal disorders.

Question 12

List three of the methods that will likely be used for the genomic characterization of tumors.

Question 13

Why is the identification of the molecular subtype of LQTS important?

Question 14

What symptoms can hereditary hemochromatosis (HH) produce, and how can presymptomatic screening for HH be clinically useful?