Deck 9: Hematologic Agents

Question 1

Which of the following drugs causes a major drug interaction when coadministered with warfarin?

A) Amlodipine
B) Amiodarone
C) Amoxicillin
D) Atenolol

Answer 1

B

Question 2

Which of the following is NOT a documented adverse effect with warfarin therapy?

A) Bleeding
B) Headache
C) Skin necrosis
D) Purple toe syndrome

Answer 2

B

Question 3

Which statement regarding warfarin is TRUE?

A) Warfarin is an anticoagulant.
B) Warfarin is an antiplatelet agent.
C) Warfarin is safe in pregnancy.
D) Warfarin is a thrombolytic agent.

Answer 3

A

Question 4

A patient taking Plavix is most likely being treated for which of the following conditions?

A) Acute coronary syndrome
B) Diabetes
C) HIV
D) Hepatitis

Question 5

All of the following are indications for using alteplase, EXCEPT:

A) Pulmonary embolism
B) Myocardial infarction
C) Stroke
D) Stable angina

Question 6

Indications for warfarin include all of the following, EXCEPT:

A) Treatment of DVT
B) Treatment of aneurysm
C) Atrial fibrillation
D) Mechanical cardiac valve replacement

Question 7

The dose for Lovenox if it is used for prophylaxis against DVT after hip replacement surgery is:

A) 30 mg Q12 hours
B) 40 mg QID
C) 60 mg BID
D) 80 mg Q12 hours

Question 8

The correct route of administration for Lovenox is:

A) Intrathecal
B) IM
C) SQ
D) PO

Question 9

What is the recommended maintenance dose of ticagrelor?

A) 90 mg BID
B) 150 mcg daily
C) 750 mg BID
D) 1.5 gm daily

Question 10

What is the route of administration for alteplase?

A) PO
B) IM
C) SQ
D) IV

Question 11

The usual dose for heparin if treating active DVT/PE is:

A) 5,000 units q8h
B) 80 u/kg IV bolus, followed by 18 u/kg/hr continuous infusion
C) 1 mg/kg q12h
D) 20,000 units q24h

Question 12

Which of the following is an indication for aspirin therapy?

A) Sarcoidosis
B) MI
C) HTN
D) COPD

Question 13

What is the antidote for unfractionated heparin?

A) Protamine
B) Vitamin K
C) Potassium
D) Vitamin B12

Question 14

Which of the following as an indication for Neulasta therapy?

A) Neutropenia associated with myelosuppressive chemotherapy
B) Anemia associated with chronic renal failure
C) Hepatitis
D) MI

Question 15

Which of the following is one of the uses for epoetin alfa?

A) Treatment of neutropenia in HIV patients
B) Treatment of anemia in cancer patients on chemotherapy
C) Treatment of HTN
D) Treatment of hepatitis

Question 16

Prasugrel belongs to which medication class?

A) Antihypertensives
B) Anticoagulants
C) Antiplatelet, thienopyridines
D) Antibiotics

Question 17

Activase has what mechanism of action?

A) Tissue plasminogen activator
B) Increases vagal tone
C) Inhibits GABA receptors
D) Inhibits prostaglandins

Question 18

Filgrastim is used in the treatment of which of the following conditions?

A) Hypertension
B) Headache
C) Neutropenia following bone marrow transplant
D) Anemia in patients with chronic renal failure

Question 19

Which of the following is an indication for Aggrenox therapy?

A) HTN
B) MI
C) TIA
D) DVT

Question 20

Neupogen is available in which dosage form?

A) Oral tablet
B) IV
C) SQ
D) B and C

Question 21

Which of the following is a common adverse reaction with the colony-stimulating factors?

A) HTN
B) Headache
C) Bone pain
D) Sickle cell crisis

Question 22

What is the antidote for dabigatran?

A) Vitamin K
B) Prothrombin complex concentrate
C) Protamine
D) Idarucizumab

Question 23

Which of the following is an indication for bivalirudin therapy?

A) UA/NSTEMI
B) STEMI Undergoing PCI
C) HIT
D) All of the above

Question 24

Bivalirudin is available in which dosage form?

A) Oral
B) SQ
C) IV
D) IM

Question 25

The dose of Pradaxa should be decreased in patients with a CrCl 30-50 mL/min who are receiving which of the following medications?

A) Amiodarone
B) Quinidine
C) Verapamil
D) Dronedarone

Question 26

Which of the following is an indication for Activase therapy?

A) Acute ischemic stroke
B) Nonvalvular atrial fibrillation
C) Heart failure
D) Mechanical valve

Question 27

Which of the following is/are contraindications to Activase therapy?

A) Recent history of CVA (past 3 months)
B) Active internal bleeding
C) Severe uncontrolled hypertension
D) All of the above

Question 28

Cilostazol is contraindicated in patients with which disease state?

A) Hypertension
B) Peripheral vascular disease
C) Asthma
D) Heart failure

Question 29

What is the INR goal for warfarin for mechanical mitral valve replacements?

A) 2-3
B) 2.5-3.5
C) 3.5-4.5
D) 3-4

Question 30

Which of the following are important counseling points regarding Coumadin?

A) Drug-drug interactions
B) Drug-food interactions
C) Risk of bleeding
D) All of the above

Question 31

Which of the following medications require routine pharmacokinetic monitoring?

A) Pradaxa
B) Rivaroxaban
C) Lovenox
D) Heparin

Question 32

Dose adjustments for Epogen and Aranesp are based on which laboratory parameter?

A) Hematocrit
B) Hemoglobin
C) Ferritin
D) Transferrin saturation

Question 33

What is the antidote for Fragmin?

A) Vitamin K
B) Protamine
C) Prothrombin complex concentrate
D) Activated charcoal

Question 34

What recommendation for treatment dosing regarding rivaroxaban administration is critical for efficacy?

A) Take on an empty stomach
B) Take every 6 hours
C) Take with food
D) Take with a full glass of water

Question 35

What is the correct route of administration for Eliquis?

A) PO
B) IV
C) IM
D) SQ