Deck 1: Drug Delivery: an Evolving Concept

Question 1

The setting of druggability and developability criteria depends on factors such as commercialization and scientific feasibility.

Answer 1

True

Question 2

Drug absorption is often limited by the presence of which of the following barriers?

A) Physiological barrier
B) Chemical barrier
C) Biochemical barrier
D) Financial Barrier

Answer 2

A,B,C

Question 3

A drug needs to be commercially viable even if it does not meet the criteria for optimum therapeutic efficacy,good safety profile (sufficient therapeutic window),and minimal adverse effects.

Answer 3

False

Question 4

In the initial stages of drug discovery,new bioactive molecules are generally identified by

A) Random High throughput screening
B) Rational Drug design
C) Both of these answers are correct
D) Neither of these answers are correct

Question 5

An in vivo model should have all the biochemical,cellular,and physiological complexities of human systems to successfully predict the actual efficacy of the drug candidate.

Question 6

Bioavailability is an important pharmacodynamics parameter.

Question 7

Total body clearance is the rate at which the systemic circulation eliminates the active drug.

Question 8

The crystalline state,salt form,and the presence of formulation excipients do not have any bearing on the overall stability of a drug.

Question 9

For most drugs (unless they are rapidly acting) low to moderate clearance is preferred.

Question 10

Toxicological studies for a new molecule are only required for acute dosing.

Question 11

As long as the active drug is safe toxicological studies for its metabolites are not required.

Question 12

Match the Factors affecting drug development
The lead molecule being developed as a drug needs to be profitable.

A) Pharmacokinetic Factor
B) Toxicology Factor
C) Commercialization Factor
D) Chemical Factor

Question 13

Match the Factors affecting drug development
The lead molecule being developed should have optimum stability,solubility and minimum interaction with excipients.

A) Pharmacokinetic Factor
B) Toxicology Factor
C) Commercialization Factor
D) Chemical Factor

Question 14

Match the Factors affecting drug development
The lead molecule being developed should have optimum absorption,distribution,metabolism,and excretion in humans.

A) Pharmacokinetic Factor
B) Toxicology Factor
C) Commercialization Factor
D) Chemical Factor

Question 15

Match the Factors affecting drug development
The new molecules need to be safe in both acute and chronic dosing.

A) Pharmacokinetic Factor
B) Toxicology Factor
C) Commercialization Factor
D) Chemical Factor

Question 16

Fill in the blanks in the figure below.

Question 17

Fill in the blank: Often,the drug is required only at the physiological___________,and hence extensive biodistribution may cause ___________and unwanted side effects.

Question 18

Fill in the blank: The new molecules need to be tested for toxicities in both________ and________ dosing because toxicological concerns are key factors in determining the developability of a drug and are a major cause of attrition.

Question 19

__________ dosing is the most common and convenient way to administer most drugs.

Question 20

Bioavailability,volume of distribution and elimination half-life are important__________ parameters.

A) Pharmacokinetic
B) Pharmacodynamic
C) Toxicologic

Question 21

Fill in the blank: No drug can be commercially viable if it does not meet the criteria for optimum ____________,good safety profile (sufficient therapeutic window),and minimal_______________.