Deck 2: Barriers to Drug Delivery

Question 1

The tightest barrier that prevents entry of drugs is the skin.

Answer 1

False

Question 2

Which of the following are the main categories of barriers?

A) Static barrier
B) Physiological barrier
C) Dynamic barrier
D) Chemical barrier
E) Biochemical barrier

Answer 2

B,D,E

Question 3

The transcellular pathway allows passive transport of all types of molecules through epithelial cells.

Answer 3

False

Question 4

Hydrophilic and large macromolecules have unfavorable properties to undergo transport through the transcellular pathway.

Question 5

Match the following with their function
Desmosomes
Zonula adherens
Zonula occludens

A) Forms free barrier against the free movement of molecules.
B) Responsible for cell-cell adhesion.
C) Responsible for linkage between desmoplakins and intermediate filaments.

Question 6

Match the following with their function
Zonula adherens

A) Forms free barrier against the free movement of molecules.
B) Responsible for cell-cell adhesion.
C) Responsible for linkage between desmoplakins and intermediate filaments.

Question 7

Match the following with their function
Zonula occludens

A) Forms free barrier against the free movement of molecules.
B) Responsible for cell-cell adhesion.
C) Responsible for linkage between desmoplakins and intermediate filaments.

Question 8

Label the intercellular complexes in the figure below.

Question 9

Fill in the blanks: Desmosomes form the _____ region of the __________________ and are located toward the ____________ side of epithelial cells

Question 10

Desmosomes play a mojor role in the barrier function of the paracellular pathway.

Question 11

Describe tight junctions.

Question 12

What are scaffolding proteins?

Question 13

There are nine domains expressed by tight junction proteins.

Question 14

Adherens junction is responsible for cell-cell adhesion.

Question 15

List the regions of lipid bilayers.

Question 16

The blood-brain barrier prevents passage of 98% small molecules but allows 100% of large molecules.

Question 17

Which one of these forms the structural framework of neurons?

A) macrophages
B) epithelial cells
C) tight junctions
D) astrocytes
E) desmosomes

Question 18

Identify the organ and label the parts in this figure.

Question 19

Arrange the layers of skin in correct order from innermost to outermost.

A) Dermis
B) Hypodermis
C) Epidermis

Question 20

Hair follicles and sweat glands constitute about 90% of total skin surface. True or False

Question 21

What are the other properties of molecules which determine permeability?

Question 22

An important factor in permeation of small molecules id hydrogen-binding potential.

Question 23

What are the modifications to improve permeability of drugs?

A) Halogenation
B) Sulfonation
C) Conjugation to biopolymers
D) Cationization
E) Hydration
F) Lipidization

Question 24

The human genome encodes different ABC transporters categorized into ________ different classes

A) Five
B) Six
C) Seven
D) Eight

Question 25

List the various regions of structural homology among ABC transporters and their associated roles.

Question 26

__________was the first characterized ABC transporter

Question 27

Explain the structural classification of Multidrug Resistant proteins (MRPs).

Question 28

The localization of MRPs in polarized cells is ________.

A) Apical
B) Basolateral
C) Apical and Basolateral
D) All of the above

Question 29

The functional requirement of BCRP is met by ________

A) Monomerization
B) Homodimerization
C) Heterodimerization
D) None of the above

Question 30

Match the ABC transporter with the respective number of TMDs.
MDR1

A) 6
B) 12
C) 17

Question 31

List the CYP families mainly involved for xenobiotic metabolism in humans.

Question 32

Briefly explain the role of CYP3A in drug delivery.

Question 33

____________ play a predominant role in lowering potential damage after exposure to various xenobiotics.