Deck 14: Vaginal Drug Delivery

Question 1

The vaginal wall is comprised of four distinct layers as listed in the options below. Choose the option that represents the correct anatomical section starting from outer to the innermost layer:

A) Epithelium,lamina propria,muscularis,tunica adventitia
B) Lamina propria,muscularis,tunica adventitia,epithelium
C) Muscularis,tunica adventitia,epithelium,lamina propria
D) Tunica adventitia,muscularis,lamina propria,epithelium

Answer 1

A

Question 2

Blood leaving the vagina enters the peripheral circulation.

Answer 2

True

Question 3

The blood leaving the vagina primarily drains into the _________________ and a minor portion reaches the _____________________.

A) Abdominal aorta,renal vein
B) Portal vein,hepatic vein
C) Basilic vein,femoral vein
D) Interior iliac vein,hemorrhoidal vein

Answer 3

D

Question 4

The principal component present in the vaginal fluid is:

A) Progesterone
B) Sweat
C) Electrolyte
D) Mucous

Question 5

The _____________________ present at the terminal ends of the oligosaccharide chain forms disulfide linkages,hydrogen bonds,and ionic bonds with mucoadhesive drugs.

A) Glutamic acid
B) Aspartic acid
C) Sialic acid
D) Folic acid

Question 6

Microbial flora particularly lactobacilli produce __________________ that prevent infections by pathogenic bacteria.

A) Nitric oxide
B) Hydrogen peroxide
C) Carbon dioxide
D) Carbon monoxide

Question 7

Which of the following is associated with the first part of menstrual cycle (follicular phase)?

A) The thickness of vaginal epithelium decreases
B) The thickness of vaginal epithelium increases
C) The thickness of vaginal epithelium remains constant
D) The thickness of vaginal epithelium decreases and then increases

Question 8

Which of the following is recognized as the most significant factor that affects vaginal residence time of dosage forms?

A) Solubility
B) Mechanism of absorption
C) Disintegration time
D) Mucoadhesion

Question 9

Which of the following adverse effects are associated with douching? (select all that apply)

A) Bacterial vaginosis
B) Pelvic inflammatory disease
C) Vaginal cancer
D) Vaginal cyst
E) Vulvovaginal candidiasis

Question 10

An important concern with the use of vaginal creams is:

A) Ease of application
B) Soothing sensation
C) Extended residence time
D) Dose inaccuracies

Question 11

A feature that distinguishes vaginal suppositories from rectal suppositories is:

A) Shape
B) Color
C) Texture
D) Odor

Question 12

The most prevalent use of vaginal rings is to deliver drugs for:

A) Systemic action
B) Local action
C) Protection from sexually transmitted disease
D) Vaccination

Question 13

A commonly used polymer in the fabrication of vaginal rings is:

A) Chitosan
B) Carboxymethyl cellulose
C) Polydimethyl siloxane
D) Poloxamer

Question 14

A vaginal ring in which the drug is homogenously dispersed in the matrix is referred to as:

A) Matrix type
B) Reservoir type
C) Sandwich type

Question 15

A state wherein two materials,one of them biological matter,are attached to each other for a prolonged time period is referred to as:

A) Biological action
B) Transmembrane diffusion
C) Bioadhesion
D) Residence time

Question 16

Identify materials that are recognized to possess mucoadhseive property. (select all that apply)

A) Polydimethyl siloxane
B) PLGA
C) Polyacrylates
D) Chitosan

Question 17

A natural material that possesses mucoadhesive property is:

A) Polyacrylic acid
B) Polyethylene glycol
C) Carrageenan
D) Polyvinyl alcohol

Question 18

A polymer that has pH sensitive property and that can be used in nanoparticles meant for vaginal delivery is:

A) Eudragit S-100
B) Hydroxymethyl cellulose
C) Hydroxypropyl methyl cellulose
D) Hyaluronic acid

Question 19

A temperature sensitive polymer that has been used in thermoresponsive vaginal gels is:

A) Poloxamer
B) Pectin
C) Gelatin
D) Polycarbophil