Deck 30: Cytogenetics

Question 1

Where is a gene designated 9p23 located?

A)short arm of chromosome 23, region 9
B)long arm of chromosome 3, region 2, band 9
C)short arm of chromosome 9, region 2, band 3
D)on the translocated part of chromosome 9 on chromosome 23

Answer 1

short arm of chromosome 9, region 2, band 3

Question 2

Cytogenetics is performed on the bone marrow of a patient,and 20 cells are examined.The patient's karyotype is reported as 47,XX,+7(14),indicating that

A)this is a female patient with trisomy chromosome 7 found in 14 of the cells examined.
B)this is a female patient with monosomy chromosome 7 found in 1 of 4 cells examined.
C)this is a male patient with trisomy 7 found in 1 of 4 cells examined.
D)this is a male patient with monosomy 7 found in 14 of the cells examined.

Answer 2

this is a female patient with trisomy chromosome 7 found in 14 of the cells examined.

Question 3

What tissue is most often studied for hematologic malignancies?

A)peripheral blood
B)bone marrow
C)spleen
D)lymph node sections

Answer 3

bone marrow

Question 4

How many chromosomes does a human with triploidy have?

A)3
B)23
C)47
D)69

Question 5

Cell division to produce daughter cells identical to the parent cell is an example of

A)nondisjunction.
B)meiosis.
C)mitosis.
D)gamete production.

Question 6

All of the following disorders are associated with acquired chromosome abnormalities except

A)megaloblastic anemia.
B)chronic myelogenous leukemia.
C)acute myeloid leukemia.
D)acute lymphoblastic leukemia.

Question 7

What is the best method for detecting chromosomal material that has been structurally altered?

A)fluorescence in situ hybridization (FISH)
B)G banding
C)Q banding
D)Ag-NOR banding

Question 8

Nonrandom chromosomal abnormalities are

A)congenital chromosome abnormalities that are consistently found in all tissues of an affected individual.
B)acquired chromosome abnormalities that are found in the abnormal or malignant tissue of an affected individual.
C)acquired chromosome abnormalities that are found in all tissues of an affected individual.
D)congenital chromosome abnormalities that are found in only one type of tissue of an affected individual.

Question 9

All of the following samples are commonly analyzed for chromosomes except

A)bone marrow.
B)amniotic fluid.
C)peripheral lymphocytes.
D)tissue with a low mitotic rate.

Question 10

Which of the following is true regarding the number of chromosomes of different species?

A)All mammals have the same number.
B)Numbers vary greatly among mammals unrelated to characteristics.
C)Primates have more than lower mammals.
D)Primates have fewer than lower mammals.

Question 11

A chromosome number that is not a multiple of the haploid number is

A)aneuploidy.
B)mosaic.
C)polyploidy.
D)incompatible with life.

Question 12

A patient has a hematologic malignancy.Karyotyping is performed for all of the following reasons except

A)to provide unique cytogenetic profile to confirm the patient's identification.
B)to provide diagnostic information.
C)to identify whether the patient will respond to appropriate therapy.
D)to provide prognostic information.

Question 13

What happens to nuclear chromatin at mitosis?

A)opens
B)condenses
C)disappears
D)develops nucleoli

Question 14

The congenital gain or loss of an entire chromosome in a developing fetus usually results in what type of clinical condition?

A)sexual ambiguity
B)myeloid leukemia
C)mental retardation
D)usually incompatible with life

Question 15

A break in two chromosomes with each piece uniting with different chromosomes is called

A)deletion.
B)duplication.
C)insertion.
D)translocation.

Question 16

What chromosome abnormality was the first to be identified and associated with a specific malignancy?

A)trisomy 8
B)deletion 7
C)Philadelphia
D)isocentric chromosome 16

Question 17

The period in the cell cycle when deoxyribonucleic acid (DNA)is synthesized is

A)G1
B)S
C)G2
D)M