Deck 36: Mature Lymphoid Neoplasms

Question 1

A middle-aged man has a white blood cell (WBC)count of 80 * 10⁹/L with 90% lymphocytes and many smudge cells.Which of the following is most likely?

A)chronic lymphocytic leukemia
B)hairy cell leukemia
C)T-cell lymphoma
D)Sézary syndrome

Answer 1

chronic lymphocytic leukemia

Question 2

What is the clinical significance of an enlarged lymph node?

A)usually benign related to an infection
B)usually indicates lymphoma
C)can be benign or malignant depending on the microscopic evaluation
D)diagnostic for an autoimmune disorder

Answer 2

can be benign or malignant depending on the microscopic evaluation

Question 3

Which of the following are mature pan-B cell markers?

A)CD4 and CD8
B)CD33 and CD45
C)CD19 and CD20
D)CD33 and CD59

Answer 3

CD19 and CD20

Question 4

Mature T cells with cerebriform,clefted nuclei found in the skin and peripheral blood describe

A)hairy cells
B)prolymphocytes
C)lymphoblasts
D)Sézary cells

Question 5

Which of the following are mature pan-T cell markers?

A)CD3 and CD5
B)surface immunoglobulin
C)CD4 and CD5
D)CD4 and CD8

Question 6

The strongest risk factor for development of a lymphoproliferative disorders is

A)age 15 to 34 years.
B)altered immune function.
C)female sex.
D)cytomegalovirus infection in childhood.

Question 7

Where are malignant plasma cells found in plasma cell myeloma?

A)bone marrow and rarely in the peripheral blood
B)lymph nodes and liver
C)spleen and liver
D)bone marrow and lymph nodes

Question 8

Normal lymph nodes contain all of the following cell types except

A)myelocytes
B)plasma cells
C)lymphocytes
D)macrophages

Question 9

Which of the following is true regarding the clinical course of chronic lymphocytic leukemia?

A)aggressive disorder that presents with severe bleeding and anemia
B)benign disorder that rarely requires treatment
C)mild symptoms but usually fatal within 6 months
D)incurable but with a median survival of approximately 10 years

Question 10

Which of the following is true regarding classic Hodgkin lymphoma?

A)It is seen in young adults and includes enlarged mediastinal lymph nodes.
B)It is seen in young children and includes splenomegaly.
C)It is seen in young adults and is rapidly fatal in most cases.
D)It is seen in older adults and spreads through the body before any symptoms develop.

Question 11

Serum protein electrophoresis on an elderly patient reveals a monoclonal protein spike.Increased plasma cells are present in the bone marrow.They are CD19 and CD20 negative but demonstrate high-density CD38 and monoclonal cytoplasmic immunoglobulin.What is the most likely diagnosis?

A)plasma cell myeloma
B)Hodgkin lymphoma
C)Burkitt lymphoma
D)chronic lymphocytic leukemia

Question 12

Malignant proliferation of plasma cells with osteolytic bone lesions and the presence of monoclonal immunoglobulin in the serum describes

A)Waldenström macroglobulinemia
B)marginal zone B-cell lymphoma
C)follicle center lymphoma
D)plasma cell myeloma

Question 13

Why are patients with plasma cell myeloma susceptible to infection?

A)decreased lymphocytes
B)neutropenia
C)suppressed normal immunoglobulin levels
D)both b and c

Question 14

Which of the following is true of plasma cells?

A)express pan-B cell markers
B)express surface immunoglobulin
C)express cytoplasmic immunoglobulin
D)express pan-T cell markers

Question 15

Neoplastic lymphocytes with noncleaved clumped nuclei and very basophilic cytoplasm with prominent vacuoles describes

A)Reed-Sternberg cells
B)mantle cell lymphoma cells
C)small-cell lymphocytic lymphoma cells
D)Burkitt lymphoma cells

Question 16

Why is Burkitt lymphoma such an aggressive malignancy?

A)Cells readily metastasize to bone marrow.
B)Cells have a high proliferative rate.
C)Cells fail to mature to functional immunophenotype.
D)Cells destroy red cells.

Question 17

What lymphoproliferative disorder has a very favorable response to highly aggressive chemotherapy with no radiotherapy?

A)chronic lymphocytic leukemia
B)mycosis fungoides
C)Hodgkin lymphoma
D)Burkitt lymphoma

Question 18

All of the following are functions of normal lymph nodes except

A)lymphopoiesis
B)granulopoiesis
C)processing antigens
D)antigen recognition

Question 19

What is the preferred specimen to evaluate cellular morphology in the lymphoproliferative disorders?

A)peripheral blood
B)bone marrow
C)node frozen sections
D)touch imprints of nodes

Question 20

What is the diagnostic cell,found in involved lymph nodes,for Hodgkin lymphoma?

A)small B lymphocyte
B)plasma cell
C)small T lymphocyte
D)Reed-Sternberg cell