Deck 37: Normal Hemostasis and Coagulation

Question 1

What is the role cofactors play in the procoagulant process?

A)bind fibrinolytic factors to slow down lysis of the clot
B)bind Ca2+ to form a bridge with platelet phospholipids
C)bind to their specific activated serine protease to stabilize the protease and increase its activity
D)bind to collagen to aid in platelet adhesion

Answer 1

bind to their specific activated serine protease to stabilize the protease and increase its activity

Question 2

What substance digests the fibrin clot after healing?

A)plasmin
B)activated protein C
C)TPA
D)a2-Antiplasmin

Answer 2

plasmin

Question 3

On what does factor VIII depend for stability?

A)VWF
B)platelets
C)thrombin
D)protein S

Answer 3

VWF

Question 4

Which of the following aids in preventing excess clotting?

A)thrombin
B)factor VII
C)nitric oxide
D)protein C

Question 5

What are the primary procoagulant roles of the blood vessel?

A)constrict and provide collagen and other compounds to activate clotting
B)prevent the blood from escaping and promote fibrinolysis
C)secrete platelet growth factors and manufacture calcium
D)constrict and synthesize most plasma coagulation factors

Question 6

All of the following are functions of thrombin except

A)activates factors V and VIII
B)activates plasminogen
C)activates factor XIII
D)initiates platelet aggregation

Question 7

Which of the following is true regarding the plasma coagulation zymogens?

A)circulate normally in their active form
B)are serine proteases that form complexes to activate other zymogens to ultimately generate thrombin
C)activation normally occurs throughout the body when vascular injury occurs
D)are cofactors that induce peptide bonding to make larger active molecules

Question 8

Which of the following is the most important protease of the coagulation pathway because of its role in so many different catalytic functions?

A)thrombin
B)factor XIa
C)plasmin
D)factor VIIa

Question 9

Oral anticoagulation is based on

A)increasing plasminogen.
B)activating plasmin.
C)combining with antithrombin.
D)vitamin K antagonism.

Question 10

Patients who have a deficiency of protein C or protein S have which type of disorder?

A)bleeding disorder
B)thrombotic disorder
C)bruising disorder
D)hypercalcemia

Question 11

Which of the following therapies actually lyses the clot rather than prevents future clots?

A)aspirin
B)heparin
C)TPA
D)Coumadin

Question 12

Where are most of the plasma procoagulant proteins produced?

A)liver
B)megakaryocytes
C)endothelial cells
D)spleen

Question 13

Which of the following is part of primary hemostasis?

A)fibrinolysis
B)blood vessels
C)intrinsic system
D)inhibitors

Question 14

What happens to the fibrin monomers created when thrombin cleaves fibrinopeptides A and B from fibrinogen?

A)immediately inactivated to prevent excess clotting
B)converted to plasminogen
C)digested quickly by tissue plasminogen activator (TPA)
D)polymerized and are stabilized by factor XIIIa

Question 15

Which of the following is necessary for platelet adhesion to collagen?

A)calcium
B)fibrinogen
C)VWF
D)factor XIII

Question 16

Which of the following is necessary for platelet aggregation?

A)protein S
B)kallikrein
C)vitamin K
D)fibrinogen

Question 17

What is the role of the thrombin-thrombomodulin complex?

A)initiates vasoconstriction
B)activates thrombin
C)inhibits factor Xa
D)activates protein C

Question 18

Which of the following are components of the contact group of factors?

A)fibrinogen and thrombin
B)VIII and VWF
C)XII and prekallikrein
D)calcium and IX

Question 19

What protein does heparin work with to inhibit coagulation?

A)protein S
B)antithrombin
C)vitamin K
D)factor VII

Question 20

Absence of D dimers is useful for ruling out

A)deep venous thrombosis (DVT)
B)von Willebrand disease (vWD)
C)protein C deficiency
D)factor VII deficiency

Question 21

What vitamin is essential for normal synthesis of prothrombin group proteins,thus enabling them to bind Ca²⁺?

A)vitamin K
B)vitamin B12
C)vitamin C
D)vitamin D

Question 22

What substance is known to inactivate cyclooxygenase,causing impairment of platelet function?

A)aspirin
B)calcium
C)Tylenol
D)vitamin K

Question 23

What plasma protein is important for normal wound healing and stabilization of the fibrin clot?

A)tissue factor
B)prothrombin
C)factor Xa
D)factor XIIIa