Deck 22: Toxicity to Reproductive Organs and Developmental Toxicity

Question 1

How does bisphenol A cause epigenetic developmental disruption?

Answer 1

Hypomethylation of phosphodiesterase Type 4 variant leads to increased expression of adult prostate cells.

Question 2

How does BPA also affect early male development?

Answer 2

BPA has hormonal activity and generates oxidative stress causing a decrease in spermatogenesis an semen quality (phthalate metabolites).

Question 3

How can the organochlorine pesticide methoxychlor affect egg layers, such as amphibians?

Answer 3

Methoxychlor causes a delay in gonadotropin-induced oviposition and number of fertilized eggs with an increase in gonadosomatic index.

Question 4

Why might exposure to burn products from forest fires be problematic for reproduction?

Question 5

What is the A/D ratio?