Deck 24: Pathogenic DNA Viruses

Question 1

Where does human herpesvirus 4 (EBV)become latent?

A) in the dorsal root ganglion
B) in B lymphocytesC) in cytotoxic T lymphocytes
D) in brachial ganglia
E) in oligodendrocytes

Answer 1

B

Question 2

What is the most prevalent viral infection seen in neonates?

A) human herpesvirus 1
B) human herpesvirus 2
C) human herpesvirus 4 (EBV)
D) varicella-zoster virus
E) cytomegalovirus

Answer 2

E

Question 3

A teenager shows up at a clinic with lesions on his face.The sores are raised,light-colored bumps with a waxy texture.A few similar lesions are present on the torso as well.With which of the following viruses might he be infected?

A) human herpesvirus 1
B) B19 virus
C) human herpesvirus 4
D) molluscum contagiosum
E) papillomavirus

Answer 3

D

Question 4

What cell type can the Simplexviruses infect latently?

A) B cells
B) epithelial cells
C) neurons
D) T cells
E) multiple cell types

Question 5

What is unique about the Hepadnaviridae family of viruses?

A) they contain RNA.
B) they contain double-stranded RNA.
C) they contain single-stranded DNA.
D) they contain double-stranded DNA.
E) they contain both single-stranded DNA and double-stranded DNA.

Question 6

Which of the following lesions is a hard,raised sore?

A) macule
B) papule
C) vesicle
D) pustule
E) pox

Question 7

Which of the follow produces a rash that leaves permanent scars on the skin?

A) Herpesviridae
B) Papillomaviridae
C) Poxviridae
D) Adenoviridae
E) Polyomaviridae

Question 8

human herpesvirus 4 (EBV)is implicated in which of the following diseases?

A) Hodgkin's lymphoma
B) cervical cancer
C) oral hairy leukoplakia
D) chronic fatigue syndrome
E) Hodgkin's lymphoma, chronic fatigue syndrome, and oral hairy leukoplakia

Question 9

An older adult is complaining of an intensely painful rash that has appeared as a patch on one side of his chest.This description is consistent with

A) chickenpox.
B) roseola.
C) shingles.
D) smallpox.
E) whitlow.

Question 10

Shingles,or herpes zoster,is caused by the virus that also causes

A) cold sores.
B) chickenpox.
C) smallpox.
D) molluscum contagiosum.
E) warts.

Question 11

Which of the following families of DNA viruses is the most prevalent in humans?

A) Poxviridae
B) Herpesviridae
C) Adenoviridae
D) Polyomaviridae
E) Rhinoviridae

Question 12

What makes neonatal herpes a very serious condition?

A) The potential for life-long infection.
B) Central nervous system infection of the neonate.
C) HHV infection of the bone marrow.
D) Development of lymphoma.
E) The potential for oncogenesis.

Question 13

Which of the following statements concerning genital warts is FALSE?

A) They can be transmitted via fomites.
B) They can travel to different locations on the same individual by autoinoculation.
C) They can be sexually transmitted.
D) The virus may remain latent and cause lesions at a later time.
E) The incidence is relatively low because treatment is available.

Question 14

Which of the following characteristics are common to Poxviridae,Herpesviridae,and Hepadnaviridae?

A) double-stranded DNA in the virion
B) a complex capsid
C) the presence of an envelope
D) double-stranded DNA in the virion with a complex capsid
E) double-stranded DNA in the virion and the presence of an envelope

Question 15

Which of the following statements is true of both molluscum contagiosum and smallpox?

A) A genital form of the disease exists.
B) A vaccine is available.
C) The causative agent is a large dsDNA virus with a complex capsid.
D) The rash forms fluid-filled vesicles that become pustules.
E) It has a morality rate of 20%.

Question 16

Characteristic features of the herpesvirus used for diagnosis include the

A) presence of recurring lesions in the lip or genital regions.
B) presence of syncytia in infected tissue.
C) presence of recurring lesions in the lip or genital regions and syncytia in infected tissue.
D) ability of the virus to be transmitted to neonates.
E) presence of viruses intracellularly years after recovery from the infection.

Question 17

High fever,headache,extreme fatigue,and a rash on the face that progresses to fluid- and pus-filled sores before crusting over and healing are signs and symptoms consistent with infection with

A) adenovirus.
B) herpesvirus.
C) papillomavirus.
D) polyomavirus.
E) poxvirus.

Question 18

Which of the following poxviruses are zoonoses?

A) molluscum contagiosum
B) smallpox
C) cowpox
D) monkeypox
E) both cowpox and monkeypox

Question 19

The polyomavirus known as BK may establish latent infection of

A) B lymphocytes.
B) liver cells.
C) bone marrow stem cells.
D) nerve cells.
E) kidney cells.

Question 20

Pinkeye can be the result of infection with

A) human herpesvirus 7.
B) a polyomavirus.
C) an adenovirus.
D) a poxvirus.
E) human herpesvirus 4.

Question 21

A young man goes to a clinic complaining of discomfort in his foot,especially when standing.Upon examination,the clinician observes raised bumps with rough surfaces on the sole of his foot.These lesions are consistent with

A) whitlow.
B) erythema infectiosum.
C) molluscum contagiosum.
D) shingles.
E) warts.

Question 22

Which of the following is the only DNA virus that can cause viral hepatitis?

A) hepatitis A virus
B) hepatitis B virus
C) hepatitis C virus
D) hepatitis D virus
E) hepatitis E virus

Question 23

Which of the following is a vaccine-preventable disease?

A) genital warts
B) genital herpes
C) fifth disease
D) infectious mononucleosis
E) roseola

Question 24

A homeschooled child recently visited an ailing great-grandparent who was complaining of a painful rash.Even though the child had had no contact with children suffering from chickenpox,the child developed chickenpox.How did the child contract the infection?

A) The virus was likely contracted from fomites.
B) The adult had chickenpox and exposed the child.
C) An insect vector infected the child.
D) The adult had shingles and the child was exposed to virus particles.
E) There is insufficient information for a conclusion.

Question 25

The large size of poxviruses allows them to

A) be easily isolated in infected cells.
B) attach to both animal and human cells.
C) provoke a strong immune response in the host.
D) travel in droplets.
E) be potential vectors for genetic engineering of vaccines.

Question 26

What is the likelihood the average college freshman has been infected with HHV-4,also known as Epstein-Barr virus (EBV)?

A) 70%
B) 40%
C) 16%
D) 4%
E) 1%

Question 27

Hepatitis B virus releases a large amount of viral antigen,which benefits the patient by

A) producing a stronger cellular immune response.
B) activating antibody mediated immunity.
C) making it easier to develop a vaccine.
D) allowing for better treatment.
E) ensuring plentiful substrate for binding with labeled antibodies in diagnostic tests.

Question 28

A new virus is discovered that has double stranded DNA and no envelope.The highly purified virions form large crystals.This new virus is most likely a member of which virus family?

A) Adenoviridae
B) Herpesviridae
C) Papillomarviridae
D) Poxviridae
E) Papillomaviridae

Question 29

What conditions may trigger reactivation of latent herpesvirus infections?

A) co-infection with hepatitis D virus
B) major hormonal changes
C) immune suppression
D) co-infection with hepatitis D virus along with hormonal changes
E) immune suppression or hormonal changes can both trigger reactivation

Question 30

Gamma interferon is sometimes used to treat infections with

A) adenoviruses.
B) herpesviruses.
C) poxviruses.
D) parvoviruses.
E) both herpesviruses and poxviruses.

Question 31

Which of the following statements concerning the hepatitis B vaccine is FALSE?

A) It must be given in three doses.
B) It is protective against the virus in 95% of vaccinated individuals.
C) It is recommended for high-risk groups.
D) It must be repeated every five years.
E) Immunity can last at least 20 years and may be for life.

Question 32

The common name for the disease caused by human parvovirus B19 is

A) kissing disease.
B) fourth disease.
C) fifth disease.
D) shingles.
E) Reyes' syndrome.

Question 33

Which of the following statements regarding the association of hepatitis B with liver cancer is FALSE?

A) Geographic areas with a high incidence of liver cancer also have a high prevalence of hepatitis B.
B) The HBV genome has been found integrated into hepatic cancer cells.
C) Hepatic cancer cells typically express HBV antigen.
D) Chronic carriers of the virus are 200 times more likely to develop hepatic cancer.
E) Vaccination does not provide protection against the development of hepatic cancer.

Question 34

What viral disease has been successfully eradicated?

A) smallpox
B) cowpox
C) vaccinia
D) varicella
E) erythrovirus

Question 35

Which of the following viruses are oncogenic?

A) parvovirus
B) human herpesvirus 4
C) papillomavirus
D) both human herpesvirus 4 and papillomavirus
E) both parvovirus and human herpesvirus 4

Question 36

Which of the following viruses is responsible for erythema infectiosum?

A) adenoviruses
B) human herpesvirus 1
C) varicella
D) human herpesvirus 4
E) B19 virus

Question 37

Which of the following viruses are the only ssDNA viruses that cause disease in humans?

A) Parvoviridae
B) Hepadnaviridae
C) Poxviridae
D) Polyomaviridae
E) Herpesviridae

Question 38

Which of the following viruses is a DNA virus that infects liver cells?

A) hepadnaviruses
B) herpesviruses
C) polyomaviruses
D) poxviruses
E) adenoviruses

Question 39

Which of the following increases the risk of permanent liver damage with hepatitis B infection?

A) coinfection with human herpesvirus 4
B) coinfection with hepatitis D virus
C) coinfection with HHV-6
D) coinfection with human herpesvirus 4 and hepatitis D virus
E) coinfection with hepatitis D virus and HHV-6

Question 40

Adenoviruses infect

A) the digestive tract.
B) the respiratory tract.
C) the nervous system.
D) both the digestive tract and the respiratory tract.
E) both the respiratory tract and the nervous system.

Question 41

The ________ primarily infects lymphocytes.

A) BK virus
B) Adenovirus
C) B19 virus
D) HHV-6
E) HHV-8

Question 42

Human herpesvirus (1/2/3/4)is usually associated with lesions on the genitalia.

Question 43

Nearly everyone appears to be infected with polyomaviruses BK and JC by the age of 15.

Question 44

Human herpesviruses have been designated by combining HHV (human herpesvirus)with numbers corresponding to the severity of the diseases they cause.

Question 45

Post-exposure vaccination is effective in reducing or preventing disease from variola infection.

Question 46

human herpesvirus 4 (EBV)has been implicated as an etiological agent in some cases of Hodgkin's lymphoma.

Question 47

An effective vaccine to prevent infection with Epstein-Barr virus (EBV,HHV-4)is available.

Question 48

Reactivation of ________ in immunosuppressed persons may produce Kaposi's sarcoma,a cancer of the blood vessels.

A) EBV
B) HHV-6
C) cytomegalovirus
D) HHV-8
E) BK virus

Question 49

Contact with a minute quantity of blood is sufficient for infection with hepatitis B virus.

Question 50

A serum sample from a patient is examined on an electron microscope,and observed to contain Dane particles,filamentous,and spherical virion particles in abundance.This observation indicates infection with

A) human herpesvirus 1.
B) EBV.
C) hepatitis B.
D) hepatitis D.
E) VZV.

Question 51

All poxviruses that infect humans are zoonoses.

Question 52

Painful,blister-like lesions that progressively become filled with pus suggest infection with a (herpesvirus/poxvirus/papillomavirus).

Question 53

The first documented human disease to be eradicated was smallpox.

Question 54

Immunization with (chickenpox/cowpox/monkeypox)will provide protection against smallpox.

Question 55

An inflamed fluid-filled lesion on the finger caused by either HHV-1 or HHV-2 is known as a (blister/wart/whitlow).

Question 56

Erythema infectiosum is a dangerous but treatable disease.

Question 57

All adenoviruses cause mild respiratory disease.

Question 58

Infection of the respiratory system by ________ may develop into symptoms of a common cold.

A) adenoviruses
B) cytomegaloviruses
C) papillomaviruses
D) polyomaviruses
E)+G1203:G1247 parvoviruses

Question 59

A childhood illness caused by a herpesvirus and characterized by a "rosy" rash all over the body is known as

A) chickenpox.
B) kissing disease.
C) CMV.
D) monkeypox.
E) roseola.

Question 60

The condition in which athletes develop herpes lesions on their skin as a result of coming in contact with herpes lesions during wrestling is known as herpes (gladiatorum/whitlow/zoster).

Question 61

B has been HIV positive for several years.Recently,B began to experience some disturbing symptoms.B has begun to have problems with vision and motor control.Clinical tests indicate B's immune function is declining.What other viruses besides HIV might be causing B's problems? How might this be verified?

Question 62

The disease caused by B19 virus,a (papillomavirus/parvovirus/polyomavirus),is known as erythema infectiosum and produces a distinctive rash.

Question 63

The disease known as molluscum contagiosum is cause by a (herpesvirus/papillomavirus/poxvirus).

Question 64

In infections with human herpesvirus (1/2/3/4),the virus becomes latent in B lymphocytes and suppresses apoptosis,contributing to lymphomas associated with this virus.

Question 65

A four-year-old with a history of cold symptoms for two days visits the doctor.On examination,the doctor notices "dewdrops on a rose petal" lesions over the child's back.From what is the child suffering? What are the potential long-term consequences of this infection?

Question 66

A wart on the bottom of the foot is known as a (flat/plantar/seed)wart.

Question 67

Compare and contrast the oncogenic viruses human herpesvirus 4 (Epstein-Barr virus)and hepatitis B virus (HBV).

Question 68

Skin lesions described as "dewdrops on rose petals" are characteristic of (chickenpox/monkeypox/shingles).

Question 69

Replication of the hepadnaviridae genome requires (RNA polymerase/reverse transcriptase).

Question 70

A patient is brought into the ER in a coma.Upon inspection,the physician sees evidence of many new tattoos,as well as yellowing of the skin and eyes.What is the most likely cause of the patient's condition?

Question 71

A child is suffering from a fever and has reddish cheeks,arms,and thighs.The rash intensifies upon exposure to the sun.What is the likely infectious agent?

Question 72

The cauliflower-like growths on the genitalia called condylomata acuminata are caused by (herpesviruses/papillomaviruses/parvoviruses).

Question 73

Hepatitis B virus replicates in liver cells and is released by (extrusion/exocytosis/lysis),which contributes to the infection becoming chronic.

Question 74

Papillomaviruses are transmitted by (aerosols/direct contact/secretions).

Question 75

Individuals who have been infected by varicella-zoster virus may develop (Kaposi's sarcoma/shingles/whitlows)later in life if they experience severe stress or immune suppression.