Deck 10: Lipid-Modifying Agents

Question 1

What is a desirable level of total cholesterol in the blood?

A) Over 240
B) Less than 200
C) 40-60
D) Directly associated with triglyceride levels
E) Nearly impossible to properly maintain

Answer 1

B

Question 2

The atherogenic triad includes all of the following EXCEPT:

A) High VLDL
B) Low HDL
C) High LDL
D) Elevated triglycerides

Answer 2

A

Question 3

How do statins primarily work?

A) By increasing muscle metabolism
B) By increasing lipoprotein lipase activity
C) By activating PPAR signaling pathways
D) By degrading LDL
E) By inhibiting HMG-CoA-reductase

Answer 3

E

Question 4

Aspirin is sometimes given in conjunction with niacin to do which of the following?

A) Further decrease LDL levels
B) Stimulate lipoprotein lipase activity
C) Minimize flushing/hot flashes
D) Increase the activity of the G-protein coupled receptor
E) Increase the amount of inhibition of HMG-CoA-reductase

Question 5

What is the effect of exercise on the pharmacokinetics of lipid-modifying agents?

A) Minimal because these drugs are taken at bedtime
B) Very pronounced because of the involvement of the liver in cholesterol levels
C) Varies greatly amongst the different classes of compounds
D) Important because all these drugs are flow-limited
E) Totally dependent on the fitness level of the patient

Question 6

The increase in lipoprotein lipase activity during exercise results in which of the following?

A) It causes a huge decrease in LDL
B) It causes triglyceride breakdown and speeds clearance of VLDL
C) It decreases HDL
D) It causes large changes in total cholesterol
E) It is dependent on PPAR signaling in both liver and muscle tissue

Question 7

Hyperlipidemia is a positive risk factor for cardiovascular disease but can be completely controlled with an appropriate diet and exercise.

Question 8

Lipid-modifying drugs like statins are only useful in the small percentage of the population that has a genetic problem in cholesterol transport.

Question 9

Lipoprotein lipase releases free fatty acids and glycerol from serum triglycerides.

Question 10

When exercising, the only source of fat available to working muscle is provided by adipose tissue.

Question 11

With regular aerobic exercise, slow twitch muscle cells, which are more efficient users of lipid sources for energy, help improve the lipid profile.

Question 12

During recovery after a bout of exercise, muscle continues uptake of lipoproteins from the blood for several hours, depending on the intensity and energy expenditure that occurred during exercise.

Question 13

Only long bouts of endurance exercise can dramatically alter the blood lipd profile.

Question 14

Muscle pain has been noted with use of statins independently of intense exercise.

Question 15

In a blood test, a good indicator of muscle cell damage is the level of _________.