Deck 1: Basic Pharmacology

Question 1

Which of the following is not considered a fundamental component of pharmacokinetics?

A) Drug metabolism
B) Down regulation of drug receptors
C) Drug elimination
D) Drug absorption
E) Drug distribution

Answer 1

B

Question 2

During moderate- to high-intensity exercise, why is the bioavailability of most drugs altered?

A) Serum proteins bind drugs tighter - with higher affinity
B) Drugs are taken up faster in the stomach
C) Blood flow decreases to the liver and kidneys
D) Metabolism in muscle tissue increases significantly
E) The rate of sweat formation increases significantly

Answer 2

C

Question 3

In an obese patient, would the dose of a fat-soluble drug be increased or decreased, and why?

A) Decreased due to the weight of the individual
B) Increased due to a slow rate of absorption
C) Decreased due to lower amounts bound to serum proteins
D) Increased due to an increase in the volume of distribution
E) Decreased due to added stress on the kidneys

Answer 3

D

Question 4

What is the name for a drug that binds and activates a receptor similar to the endogenous molecule?

A) An antagonist
B) An agonist
C) A competitive inhibitor
D) A suicide substrate
E) An allosteric effector

Question 5

A dose-response curve is useful in determining which of the following?

A) Rates of drug elimination
B) The drug's volume of distribution
C) The number of genes involved in that drugs metabolism
D) A drug's potency
E) The best route of administration

Question 6

An ergogenic drug is one that does what?

A) Improves exercise performance
B) Increases the rate of elimination
C) Causes performance to deteriorate
D) Alters the rate of metabolism of other drugs
E) Displaces drugs from non-specific binding sites

Question 7

How is the therapeutic index (TI) used?

A) To determine if a drug is ergolytic
B) To determine the relative safety of a drug
C) To determine the potency of a drug
D) To determine the efficacy of a drug
E) To determine the rate that a drug is metabolized

Question 8

Some drugs that are taken over a long period of time can cause significant problems when their use is abruptly stopped. Which of the following is true regarding these problems?

A) They are called a withdrawal syndrome.
B) They are due to the ergogenic nature of the drug.
C) They are determined from dose-response curves.
D) They are based mostly on the pharmacokinetic properties of the drug.
E) They are dependent of the liver status of the individual.

Question 9

All humans contain the exact same enzymes, so drug metabolism is the same for all races.

Question 10

When most drugs enter the body, they bind to a specific receptor and can alter normal physiological processes.

Question 11

Whether a person responds to a drug or shows unwanted side effects is probably due to the interactions of several genes.

Question 12

Examination of the dose-response curves for related drugs can help determine which drug has the highest efficacy.

Question 13

Drug tolerance is when more drug is needed to get the same desired effect over time.

Question 14

Intense exercise rarely alters a drug's bioavailability.

Question 15

The therapeutic window is the desired range of blood concentration that is not toxic but still provides therapy.