Deck 5: Advanced Spectroscopy

Question 1

The technique of ____ can employ chemical processes to fragment molecules.

A) HPLC
B) mass spectrometry
C) NMR
D) IR spectroscopy

Answer 1

B

Question 2

To determine the presence of fentanyl or its derivatives by its mass and fingerprint, _____ should be used.

A) TLC
B) GC
C) HPLC
D) MS

Answer 2

D

Question 3

The observation that no two substances produce the same fragmentation patterns under carefully controlled conditions is a unique feature of:

A) electromagnetic radiation.
B) ultraviolet spectrophotometry.
C) thin-layer chromatography.
D) mass spectrometry.

Answer 3

D

Question 4

The tallest peak in a mass spectrum is termed the

A) base peak.
B) molecular ion peak.
C) fragment peak.
D) terminal peak.

Question 5

The technique of ____ can be used to determine the chemical structure of a molecule.

A) HPLC
B) SEM
C) NMR
D) IR spectroscopy

Question 6

Diagram and label the parts of a mass spectrometer.

Question 7

Explain how EI works.

Question 8

Explain how CI works.

Question 9

Why can both positive and negative ions be produced with CI but not EI?

Question 10

Assign the fragments using mass spectrometry for amphetamine.

Question 11

Explain how NMR works.

Question 12

Why is peak splitting often observed with proton NMR but not carbon NMR?

Question 13

Explain chemical shielding and coupling in NMR.