Deck 11: Drugs for the Treatment of Pain and Inflammation

Question 1

Pain can be classified as _______________.

A)nociceptive pain arising from nerve damage
B)neuropathic pain arising from injury
C)psychogenic pain arising from a psychological disorder
D)all are correct

Answer 1

psychogenic pain arising from a psychological disorder

Question 2

Which one of the following statements is true?

A)Neuropathic pain can effectively be treated with antidepressants.
B)A fixed dosing schedule with opioids seems to be superior to giving medication on an as needed administration for cancer pain.
C)Cox-2 inhibitors can be used for post-op pain especially in a cardiac patient.
D)OTC aspirin and ibuprofen are safer than other prescription NSAIDs.

Answer 2

A fixed dosing schedule with opioids seems to be superior to giving medication on an as needed administration for cancer pain.

Question 3

The hallmarks of an early inflammation are _______________.

A)redness and pain
B)swelling and warmth
C)tissue destruction
D)All of the above

Answer 3

tissue destruction

Question 4

Which of the following substances inhibits pain impulses?

A)substance P
B)Serotonin
C)prostaglandins
D)glutamate

Question 5

Which of the following is recommended when taking both an NSAID for inflammation and low-dose aspirin for cardiac protection?

A)The NSAID should be given 2 hours before the aspirin.
B)The aspirin should be given 2 hours before the NSAID.
C)The aspirin should be given on one day and the NSAID on the next day.
D)Dosing with aspirin and NSAIDs is contraindicated because of increased GI bleeding.

Question 6

A patient taking aspirin or NSAIDs should be regularly monitored for which of the following?

A)Hypotension
B)Menstrual cramps
C)Petechiae
D)Elevated liver transaminases

Question 7

Opioids are classified into _______________.

A)strong opioids like codeine and propoxyphene
B)weak opioids like fentanyl and meperidine
C)mixed agonists like naloxone and naltrexone
D)none of the above

Question 8

A patient in ambulation training is on warfarin after a stroke.He is developing some tendonitis and is asking your opinion on which aspirin-type drug is better for pain,Aleve or Motrin.Your best response should be which of the following?

A)Inform the patient of the potential drug interactions with anticoagulants.
B)Inform the patient to administer a 650-mg dose of aspirin.
C)Explain that tendonitis is an expected outcome of therapy and it will improve shortly with more therapy.
D)Suggest that the patient take ibuprofen instead.

Question 9

NSAIDs drugs _______________.

A)block the conversion of arachadonic acid to prostaglandin formation
B)are antiinflammatory at lower and analgesic at higher doses
C)differ markedly in efficacy
D)differ significantly in their adverse reactions

Question 10

The action of prostaglandins includes which of the following?

A)uterine relaxation
B)reduction in body temperature
C)stabilization of gastric mucosa
D)vasodilatation of renal blood supply

Question 11

Adverse effects of opioids include which of the following?

A)Respiratory depression
B)Pupil dilation
C)Increased GI smooth muscle tone
D)Weight loss

Question 12

Which one of the following statements regarding NSAIDs is true?

A)They reduce pain and allow more rigorous training to be performed to obtain better muscle strength.
B)They may produce low BP in some individuals.
C)They are useful in reducing pain and inflammation but caution should be applied when used in patients with HTN.
D)They have replaced acetaminophen as the drug of choice in the treatment of osteoarthritic knees.

Question 13

Aspirin _______________.

A)induced damage even at low doses manifests itself quickly
B)in large doses can alter the acid-base balance
C)should be taken with plenty of fluids but not with food
D)is the preferred drug for children with viral infections

Question 14

Which one of the following is not a vasodilating,inflammatory mediator?

A)Certain prostaglandins
B)Bradykinin
C)Histamine
D)Thromboxane

Question 15

Which one of the following statements concerning cyclooxygenase or COX is correct?

A)COX 1 is involved in the production of some helpful prostaglandins.
B)COX 2 is induced with injury.
C)COX 3 may be present in the brain.
D)All of the above

Question 16

Which of the following enzymes are released from synoviocytes with tissue injury?

A)COX-1
B)COX-2
C)COX-3
D)Lipoxygenase

Question 17

Death due to an overdose of morphine is due to _______________.

A)respiratory depression
B)ventricular fibrillation
C)bronchoconstriction
D)All of the above

Question 18

Which of the following statements is true?

A)Morphine is metabolized to the inactive metabolite morphine-6-glucuronide.
B)Morphine and codeine can be given together for stronger pain relief.
C)Codeine is converted to morphine in the body.
D)Strong opioids bind strongly to kappa receptors.

Question 19

Which one of the following is not a typical adverse reaction of the opioids?

A)Mydriasis
B)Constipation
C)Nausea and vomiting
D)Pruritis

Question 20

NSAIDs drugs can be divided into _______________.

A)COX 1 and 2 inhibitors
B)COX 2 inhibitors
C)COX 3 inhibitors
D)All of the above

Question 21

Recent research on antiinflammatory drugs suggests that the main disadvantage of COX-2 inhibitors compared to the nonselective agents is increased ___________.

A)Gastric bleeding
B)Cardiac events
C)Sedation
D)Dehydration

Question 22

A patient who takes opioids over a long period of time may need which of the following drugs?

A)Laxative
B)Anticholinergic
C)Adrenergic agonist
D)Antidiarrheal