Question 1

A patient treated with antispastic medications would not be expected to experience _____________.&#10;A)muscle weakness&#10;B)decreased walking speed&#10;C)renal problems&#10;D)sedation

Accepted Answer

Hepatotoxicity is often encountered.All the others are typical adverse reactions.

Question 2

Tizanidine _____________.&#10;A)interacts with beta 1 receptors in the CNS&#10;B)affects mostly monosynaptic pathways&#10;C)treated patients must be watched for signs of tachycardia and hypertension&#10;D)shows the least muscle weakness among antispastic medications

Accepted Answer

It interacts with alpha 2 receptors and affects polysynaptic pathways.Alpha 2 effects,in addition to its antispastic action,include decreased sympathetic outflow from the brain reducing heart rate and blood pressure.

Question 3

Fluori-Methane _____________.&#10;A)should be sprayed from muscle insertion to origin of muscle&#10;B)spray should be applied to an untouched muscle&#10;C)should be sprayed until the muscle is super-cooled&#10;D)can be reapplied after the muscle has warmed

Accepted Answer

It should be sprayed from muscle origin to insertion.The muscle should be passively stretched.The muscle should be cool,but avoid super-cooling.

Question 4

Dantrolene _____________.&#10;A)reduces Ca&#8314;&#8314; fluxes at the sarcoplasmic reticulum&#10;B)is ineffective for upper motoneuron disease or injury&#10;C)can cause malignant hyperthermia&#10;D)acts only peripherally without causing CNS effects

Accepted Answer

It can be used to treat upper motoneuron disease or injury.It is the drug to treat drug induced malignant hyperthermia and can also cause (in addition to its peripheral action)drowsiness and dizziness.

Question 5

Lack of functional gain when baclofen or another antispasticity agent is administered may be caused by which of the following?&#10;A)Muscle weakness&#10;B)Seizures&#10;C)Rebound spasticity&#10;D)Enhanced muscle spindle sensitivity

Accepted Answer

Reducing or removing spasticity uncovers weak muscles.

Question 6

Cyclobenzaprine _____________.&#10;A)acts in the spinal cord&#10;B)can be used for months&#10;C)can cause an uncomfortable dry mouth&#10;D)relaxes muscles but has no effect on pain

Accepted Answer

It has anticholinergic actions including urinary retention,constipation,dry skin,tachycardia and increase in ocular pressure in glaucoma.It acts in the brain stem with an uncertain mechanism,should be used only for 2-3 weeks and also relieves pain.

Question 7

The antispastic action of diazepam _____________.&#10;A)is due to its binding to the GABAA gated Cl&#8315; channel&#10;B)occurs within the motor cortex and basal ganglia&#10;C)occurs also by an additional direct effect on skeletal muscles&#10;D)All of the above

Accepted Answer

It acts in the brain stem,reticular formation,and spinal pathways and has no direct effect on muscles.

Question 8

Advantages of neurolytic agents include _____________.&#10;A)rapid onset of action&#10;B)low cost&#10;C)action on both sensory and motor nerves&#10;D)All of the above

Accepted Answer

Neurolytic agents have several advantages including rapid onset of action, low cost, and the ability to act on both sensory and motor nerves, making "All of the above" the correct choice.

Question 9

Baclofen _____________.&#10;A)is an analog of the neurotransmitter glutamic acid&#10;B)may improve memory and attention&#10;C)in overdose causes extreme agitation and seizures&#10;D)can reduce spasticity and improve gait and ADLs

Accepted Answer

Baclofen is an analog of GABA which binds to the GABA B receptor and inhibits motoneuron activity.Baclofen in large doses can cause sedation,confusion,and respiratory depression.Studies are variable in terms of showing improvement in gait and ADLs; however,many patients report improvement in spasticity.More sensitive outcome measures may be indicated.

Question 10

Botulinus toxins _____________.&#10;A)consist of two distinct species&#10;B)begin working within 2 hours&#10;C)have been associated with some muscle necrosis&#10;D)might cause some transient muscle weakness

Accepted Answer

The answer of Botulinus toxins _____________.&#10;A)consist of two distinct species&#10;B)begin...

Question 11

Disadvantages of neurolytic agents include _____________.&#10;A)risk of dysesthesias&#10;B)involuntary muscle contractions&#10;C)hypertrophy of skeletal muscles&#10;D)All of the above

Accepted Answer

The answer of Disadvantages of neurolytic agents include _____________.&#10;A)risk of...

Question 12

Which of the following statements is correct?&#10;A)Botulinus toxin selectively destroys skeletal muscle cholinergic receptors.&#10;B)A nerve block is caused by an injected chemical which impairs nerve function.&#10;C)Ethanol causes a nerve block lasting up to 6 months.&#10;D)Ethanol selectively destroys the spinal nerve terminals.

Accepted Answer

The answer of Which of the following statements is correct?&#10;A)Botulinus...

Question 13

The drug with the longest duration of action is _____________.&#10;A)botulinus toxin&#10;B)diazepam&#10;C)cyclobenzaprine&#10;D)baclofen

Accepted Answer

The answer of The drug with the longest duration of...

Question 14

Which of the following drugs is used for muscle spasms?&#10;A)Tizanidine&#10;B)Cyclobenzaprine&#10;C)Botulinus toxin&#10;D)Dantrolene

Accepted Answer

The answer of Which of the following drugs is used...

Deck 16: Antispasticity Medications and Skeletal Muscle Relaxants