Deck 3: Pharmaceutical

Question 1

Drugs undergo various metabolic processes that affect the solubility of the drug. Which of the following enzymatic reactions would most likely result in the least change in water solubility?

A)Glucuronidation
B)Hydroxylation
C)Sulphonation
D)Cyclization

Answer 1

Hydroxylation

Question 2

Which of the following drugs is not an MAOI (Mono Amine Oxidase Inhibitor)?

A)Selegiline
B)Moclobemide
C)Citalopram
D)Isoniazid

Answer 2

Citalopram

Question 3

Which of the following drugs is a sulfonylurea?

A)Glipizide
B)Olmesartan
C)Piroxicam
D)Sirolimus

Answer 3

Glipizide

Question 4

Cholestyramine should be taken with which of the following?

A)A carbonated beverage because it increases absorption
B)Water only
C)Either water or a food like applesauce or a smoothie
D)Answers B and C are correct

Question 5

What is the best way for a bisphosphonate to be taken?

A)With minimum water and in the evening at least two hours after a meal
B)In the morning at least 30 minutes before any meal and with a full glass of water
C)Anytime during the day with no food requirements
D)Right before bedtime

Question 6

When using which of the following creams should intercourse be avoided because the cream reduces contraceptive effectiveness?

A)Metronidazole
B)Vagifem
C)Miconazole
D)Clindamycin

Question 7

Zolpidem (Ambien) should be used for:

A)Long term use: 6-12 months
B)Medium term use: up to three months
C)Short term use: 7-10 days
D)For as long as a patient needs to take it

Question 8

A patient calls and asks if they can bring in one of their vitamin solutions because it has lost its label. You are told that the solution is light red or pink. Which is the most likely vitamin in that solution?

A)Vitamin E
B)Vitamin D
C)Vitamin K
D)Vitamin B₁₂

Question 9

The FDA (Food and Drug Administration) has approved the use of decongestants for which of the following conditions?

A)Sinusitis
B)Sinusitis and allergic rhinitis
C)Sinusitis, rhinitis, and the common cold
D)Allergic rhinitis and the common cold

Question 10

Which of the following fentanyl preparations is used for chronic pain?

A)Fentora
B)Actiq
C)Duragesic
D)All of the above are useful for chronic pain.

Question 11

Which of the following vitamins can turn urine a bright yellow?

A)Vitamin C
B)Vitamin B₁₂
C)Vitamin B₂
D)Folic acid.

Question 12

Which of the following vitamins are water soluble and are excreted in the urine?
I. Vitamin C
II. Vitamin B₁₂
III. Vitamin D
IV. Vitamin E

A)I and II only
B)I and III only
C)III and IV only
D)II and IV only

Question 13

Which of the following has a "Black Box Warning" associated with it?

A)Namenda
B)Dronabinol
C)Propofol
D)Nadolol

Question 14

Which of the following warnings should be listed on a prescription for tetracycline?

A)Avoid sunlight.
B)Take with milk to avoid stomach upset.
C)May be taken within 1 hour of alcohol consumption.
D)None of the above

Question 15

Of the following drugs, which are considered positive inotropes?
I. Digoxin
II. Dopamine
III. Dobutamine

A)Digoxin only
B)Dopamine and Dobutamine only
C)All three are positive inotropes.
D)None of the three listed agents are positive inotropes.

Question 16

A patient using nitroglycerin approaches you asking what possible side effects there might be. What could you tell him?
I. Arrhythmias
II. Headache
III. Syncope

A)I only
B)II only
C)II and III only
D)All are possible side effects.

Question 17

What is the most common and most serious adverse effect of clindamycin?
I. Pseudomembranous colitis
II. Neutropenia
III. Hematuria

A)I only
B)II only
C)III only
D)I and II only

Question 18

A patient is on lovastatin. What is the biochemical pathway that is inhibited by this drug?

A)The mevalonate pathway
B)The hexose monophosphate shunt
C)The eicosanoid pathway
D)The pentose phosphate pathway

Question 19

Ketoprofen is used to treat _______ and is contraindicated with/in ___________.

A)Infection with Gram (+) bacteria, blood dyscrasias
B)Pain and inflammation, peptic ulcer disease
C)NIDDM, respiratory arrest
D)Osteoporosis, leukemia

Question 20

Colchicine is used to treat _______ and is contraindicated with/in ___________.

A)Gout, blood dyscrasias
B)Rheumatoid arthritis, high serum RF
C)Chronic lactic acidosis, respiratory arrest
D)Gout, exacerbations

Question 21

A comparison is made for the bioavailability of a particular drug. It is given as a single oral dose and as a single iv dose. When comparing the AUC (Area under Curve) for each of these delivery systems, which of the following results is possible?
I. AUC(iv) < AUC(po)
II. AUC(iv) > AUC(po)
III. AUC(iv) = AUC(po)

A)Not enough information is given to determine which result is possible.
B)I only
C)II only
D)II or III only

Question 22

A patient diagnosed with PCOS (Polycystic Ovarian Syndrome) is prescribed clomiphene citrate. What would you tell her about the primary side effects?

A)The primary side effects include breast discomfort and increased urinary frequency.
B)The primary side effects include breast discomfort and increased appetite.
C)The primary side effects include breast discomfort, hot flashes, and ovarian enlargement.
D)The primary side effects include breast discomfort and migraines.

Question 23

A patient is diagnosed with Hashimoto's thyroiditis. She is placed on levothyroxine. Which of the following statements is true?

A)Levothyroxine is synthetic T4 and is converted by the body into the active form, T3.
B)Levothyroxine should be taken with food to increase absorption.
C)Levothyroxine, once prescribed, will rarely need adjusting.
D)Levothyroxine should be taken 3 times a day, with meals, to maintain proper blood levels.

Question 24

Of the following medications, which is the only one used to treat Grave's Disease?

A)Androstenedione
B)Propylthiouracil
C)Cytomel
D)Finasteride

Question 25

A patient that is newly diagnosed with multiple sclerosis (MS) comes in to your pharmacy and is anxious about the interferon injections she was told to give herself. What would be among the things you tell her?

A)Freeze the pre-made syringe and thaw it out about an hour before you need to inject.
B)Keep the syringe in the refrigerator, rotate the areas where you inject, and use NSAIDS for any flu-like symptoms.
C)You can store the syringe at room temperature.
D)There must be a mistake-interferon is not used to treat MS.

Question 26

Which of the following drugs is used to treat migraines?

A)Tolcapone
B)Butorphanol
C)Amlodipine
D)None of the above are used to treat migraines.

Question 27

Carbamazepine is a ____________ used to treat __________ and which rarely has the adverse effect of inducing ____________.

A)Dopamine analog, Parkinson's disease, coma
B)Voltage-gated Na channel blocker, Parkinson's disease, aplastic anemia
C)Voltage-gated Na channel blocker, seizure disorders, agranulocytosis
D)Serotonin antagonist, seizure disorders, tachycardia

Question 28

Which of the following is the brand name for cyclosporine?

A)Remicade
B)LoSpor
C)Sandimmune
D)Sterapred

Question 29

Which of the following disorders is a contraindication for the use of mesalamine?

A)G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency
B)A history of renal disease
C)A history of breast cancer
D)Cardiac arrhythmias

Question 30

Which of the following drugs are metabolized via the CYP2C9 pathway?

A)Warfarin
B)Alprazolam
C)Theophylline
D)Fluoxetine

Question 31

A patient has a Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency. Of the following drugs, which should be avoided in this patient?

A)Quinolones
B)Macrolides
C)Omeprazole
D)Vitamin B₁₂

Question 32

Which of the following can induce a photoreaction in a sensitive individual?
I. ketoconazole
II. naproxen
III. vinblastine
IV. nateglinide

A)I and II only
B)I and IV only
C)I, II and III only
D)III only

Question 33

Which of the following is true of NSAIDs for pain management?
I. NSAIDs are analgesic and anti-inflammatory.
II. NSAIDs can cause GI upset and GI bleeds.
III. They inhibit prostaglandin synthesis via the lipo-oxygenase pathway.
IV. Indomethacin should not be taken in excess of 200 mg per day.

A)All the statements are true.
B)None of the statements are true.
C)Statements I, II and IV are true.
D)Statements I, II and III are true.

Question 34

For the following chemotherapeutic agents, determine the incorrect combination of agent/mechanism of action.
I. Cyclophosphamide/alkylating agent
II. Paclitaxel/anti-mitotic
III. Leuprolide/Leukocyte antagonist
IV. Doxorubicin/alkylating agent

A)I and II only.
B)II and IV only.
C)III and IV only.
D)I and III only.

Question 35

Which of the following are common anti-emetics used as adjuncts in chemotherapy?

A)Aprepitant
B)Ondansetron
C)Metoclopramide
D)All of the above.

Question 36

Which of the following are colony-stimulating factors?

A)Ondansetron
B)Filgrastim
C)Anastrozole
D)None of the above

Question 37

What is the mechanism of action of aprepitant (Emend)?

A)Aprepitant is a neurokinin-1 antagonist.
B)Aprepitant is a 5HT3 antagonist.
C)Aprepitant is a corticosteroid analog.
D)Aprepitant is a dopamine-2 antagonist.

Question 38

Of the following medications, which is the only anxiolytic?

A)Olanzapine
B)Oxcarbazepine
C)Chlordiazepoxide
D)Finasteride

Question 39

Timolol is a ____________ used to treat __________ and which rarely has the adverse effect of inducing ____________.

A)Non-selective beta-blocker, hypotension, tachycardia
B)Voltage-gated Na channel blocker, hypertension, aplastic anemia
C)Non-selective beta-blocker, open-angle glaucoma, bradycardia
D)Serotonin antagonist, seizure disorders, tachycardia

Question 40

Which of the following medications is a Pregnancy Category X?

A)Methotrexate
B)Ranolazine
C)Dronabinol
D)Infliximab

Question 41

Which of the following is a brand name for famotidine?

A)FamDeet
B)Plendil
C)Pepcid
D)Plaquenil

Question 42

Which of the following may be used as an antidote to benzodiazepine overdose?
I. Flumazenil
II. Nalmefene
III. Physostigmine
IV. Protamine

A)I only
B)II only
C)I, II and III only
D)IV only

Question 43

Which of the following conditions is a contraindication for the use of epoetin alfa?

A)Hemoglobin levels over 14
B)Hemoglobin levels below 10
C)A history of blood dyscrasias
D)Patent ductus arteriosus

Question 44

Which of the following would be considered a contraindication for the use of bisacodyl?

A)Pregnancy
B)Grave's Disease
C)Male pattern baldness
D)Intestinal obstruction

Question 45

Which of the following drugs is not an antitubercular medication?

A)Dapsone
B)Rifapentine
C)Pyrazinamide
D)Aripiprazole

Question 46

Why is carbidopa added to levodopa for the treatment of Parkinson's disease?

A)It prevents degradation of levodopa in the periphery.
B)It minimizes some of the side effects of levodopa used alone.
C)Addition of carbidopa stabilizes levodopa by interfering with Phase III metabolism.
D)Carbidopa complexes with levodopa to allow increased solubility.

Question 47

Which of the following forms is clotrimazole available in?
I. Troche
II. Tablet
III. Cream
IV. Capsule

A)I only
B)I, II and III only
C)IV only
D)Clotrimazole is available in all the listed forms.

Question 48

Which of the following is the generic name of Cytotec?

A)Moricizine
B)Modafinil
C)Misoprostol
D)Lisinopril

Question 49

Which of the following is a potential side effect of niacin?

A)Flushing
B)Hepatic necrosis
C)Atrial fibrillation
D)All of the above

Question 50

Which of the following are possible adverse effects of metaproterenol?
I. Bronchospasm
II. Cardiac arrest
III. Tinnitus

A)I and II only.
B)II and III only.
C)I and III only.
D)All of the above are possible adverse effects.

Question 51

Which of the following is not an anti-arrhythmic?

A)Sotalol
B)Adenosine
C)Propafenone
D)Bumetanide

Question 52

Which of the following are Angiotensin II receptor antagonists?
I. Medoxomil
II. Irbesartan
III. Losartan

A)All of the above
B)None of the above
C)I only
D)II and III only

Question 53

When discussing contraception with a patient, which of the following is true?
I. A NuvaRing should be inserted monthly.
II. A Seasonale user will likely have a period every three months.
III. The use of either NuvaRing or Seasonale will not protect against Sexually Transmitted Infections (STIs).

A)I only.
B)III only.
C)I, II and III.
D)I and III only.

Question 54

What is the mechanism of action of tolterodine (Detrol)?

A)Tolterodine is an anti-cholinergic agent.
B)Tolterodine is a 5HT3 antagonist.
C)Tolterodine is a corticosteroid analog.
D)Tolterodine is a GABA agonist.

Question 55

Of the following medications, which is the only tocopherol?

A)Vitamin A
B)Vitamin E
C)Vitamin D
D)Vitamin K

Question 56

Which of the following is an antitubercular medication?

A)Aripiprazole
B)Haloperidol
C)Moricizine
D)Isoniazid

Question 57

Which of the following drugs are hypoglycemics and used to treat diabetes?
I. Acarbose
II. Tolazamide
III. Glyburide
IV. Mirtazapine

A)All of the above
B)None of the above
C)I, II and III only
D)I and II only

Question 58

Levetiracetam is a(n) ____________ used to treat __________ and which rarely has the adverse effect of inducing ____________.

A)Selective beta-blocker, hypotension, tachycardia
B)Anticonvulsant, partial seizures, neutropenia/leukopenia
C)Antidepressant, seasonal affective disorder, bradycardia
D)Serotonin antagonist, seizure disorders, tachycardia

Question 59

Which of the following medications is a synthetic nucleoside analog?

A)Methotrexate
B)Ribavirin
C)Ritonavir
D)Stavudine

Question 60

Which of the following is a brand name for indinavir sulfate?

A)IndiVir
B)DinoBlast
C)Crixivan
D)Crixiblast

Question 61

Which of the following conditions is a contraindication for the use of valproic acid?

A)Post-traumatic seizures
B)A history of drug abuse
C)A history of diabetes
D)A history of ulcerative disease

Question 62

Which of the following would be considered a contraindication for the use of 5-Fluorouracil (5FU)?
I. Serious infection
II. Bone marrow depression
III. Pregnancy or lactation
IV. A history of depression

A)I and II only
B)II and III only
C)I, II and III only
D)All of the above.

Question 63

Which of the following drugs is not a bronchodilator?

A)Aminophylline
B)Salmeterol
C)Isoproterenol
D)Atenolol

Question 64

Which of the following trade names is not correctly matched with its generic name?

A)Zyprexa-Olanzapine
B)Bactroban-Mupirocin
C)Planovil-Felodipine
D)Anafranil-Clomipramine
E)Focalin-Dexmethylphenidate
F)Arava-Leflunomide
G)Selecta-Citalopram
H)Mycobutin-Rifabutin
I)Topotecan/Hycamtin
J)Aminocaproic acid/Amicar
K)Amiloride/ Midamorning
L)Diazepam/Valium
M)Progesterone-Crinone
N)Pyridostigmine-Mestinon
O)Edrophonium-Reversol
P)Emtricitabine-Mombinine
Q)Zaroxolyn-metolazone
R)Reglan-metoclopramide
S)Methozole-methimazole
T)Alupent-metaproterenol
U)Amoxapine-Asendin
V)Bisoprolol-Zebeta
W)Donepezil-Aricept
X)Furosemide-Lanstix
Y)Dronabinol-Marinol
Z)Cefotaxime-Claforan
AA)Paricalcitol-Zemplar
AB)Duloxetine-Symphonium

Question 65

Which of the following is the brand name of quinapril HCl?

A)Quinine
B)Accutane
C)Accupril
D)Lisinopril

Question 66

Which of the following is a potential side effect of lisinopril?

A)Hyperglycemia
B)Hyperuricemia
C)Hyperkalemia
D)Hypokalemia

Question 67

Which of the following are possible adverse effects of emtricitabine (Emtriva)?
I. Cushingoid symptoms
II. Lactic acidosis
III. Hepatotoxicity

A)I and II only
B)II and III only
C)I and III only
D)All of the above are possible adverse effects

Question 68

Which of the following is not a loop diuretic?

A)Bumetanide
B)Furosemide
C)Budesonide
D)Torsemide

Question 69

Which of the following are alkylating agents?
I. Chlorambucil
II. Lomustine
III. Chloramphenicol

A)I and II only
B)None of the above
C)I only
D)II and III only

Question 70

Of the following generic and brand names, which are incorrectly matched?

A)Fexofenadine, Allegra
B)Miglitol, Glyset
C)Docetaxel, Docetere
D)Pramipexole, Mirapex
E)Abacavir/Ziagen
F)Apomorphine. Apokyn
G)Flucytosine/Flucon
H)Gabapentin/Neurontin
I)Fenofibrate -Tricor
J)Frovatriptan-Frova
K)Hyoscyamine-Hyospastine
L)Hydroxyzine-Atarax

Question 71

Which of the following is a 5-alpha reductase inhibitor?

A)Aripiprazole
B)Dutasteride
C)Treprostinil
D)Isoniazid

Question 72

Methimazole is a(n) ____________ used to treat __________ and which rarely has the adverse effect of inducing ____________.

A)Anti-infective, severe opportunistic infections, thrombocytopenia
B)Thyroid hormone antagonist, Grave's disease, thrombocytopenia
C)Antidepressant, premenstrual dysphoria, thrombocytopenia
D)Serotonin antagonist, insomnia, thrombocytopenia

Question 73

Which of the following classes of medications should not be taken with St John's wort?
I. MAOI inhibitors
II. SSRIs
III. Hormonal contraceptives
IV. Vinca alkaloids

A)I and II only
B)I, II and III only
C)I and III only
D)All of the above

Question 74

Which of the following should not be taken with ginseng?

A)MAO inhibitors
B)Antimicrobials
C)Thiazide diuretics
D)Anticholinergics

Question 75

Which of the following drugs is not a bisphosphonate?

A)Alendronate
B)Risedronate
C)Zoledronic acid
D)Phytate

Question 76

Diovan is a combination of which two medications?

A)Triamterene and hydrochlorothiazide
B)Losartan and hydrochlorothiazide
C)Valsartan and hydrochlorothiazide
D)Propranolol and hydrochlorothiazide

Question 77

Which of the following are possible adverse effects of isradipine?
I. Arrhythmias
II. Leukopenia
III. Increased chance of infection

A)I and II only
B)II and III only
C)I and III only
D)All of the above are possible adverse effects

Question 78

Which of the following is not an antiparkinsonian drug?

A)Entacapone
B)Ropinirole
C)Amantadine
D)Treprostinil

Question 79

Which of the following are Angiotensin Converting Enzyme Inhibitors?
I. Enalapril
II. Lisinopril
III. Alfentanil

A)All of the above
B)None of the above
C)I only
D)I and II only

Question 80

Which of the following is a barbiturate sedative/hypnotic agent?

A)Zaleplon
B)Flurazepam
C)Pentobarbital
D)Dexmedetomidine