Deck 2: Absorption and Administration of Medicinal Agents

Question 1

The order of dissolution and absorption for different solid dosage forms is

A)Stable > Amorphous > meta-stable
B)Amorphous > meta-stable > stable
C)Meta-stable > stable > Amorphous
D)None of the above

Answer 1

Amorphous > meta-stable > stable

Question 2

According to pH partition theory, a weak acidic drug will most likely be absorbed from the stomach because the drug which exists primarily in the………….

A)un-ionised, more lipid soluble form
B)ionised, more water soluble form
C)form of weak acid and more soluble in acid media
D)ionic form of the drug which facilitates diffusion

Answer 2

un-ionised, more lipid soluble form

Question 3

Noyes and Whitney equation is used to describe____________

A)Absorption
B)Dissolution
C)Distribution
D)Disintegration

Answer 3

Dissolution

Question 4

Amorphous forms of drugs are

A)less soluble than crystal forms
B)more soluble than crystal forms
C)also called solvates
D)practically insoluble

Question 5

Which of the following forms inclusion complex and improves aqueous solubility and dissolution rate?

A)Cyclodextrins
B)PEG
C)PVT
D)Poloxamer

Question 6

Drugs undergoing first pass metabolism are advised not to be administered through

A)Oral route
B)Rectal route
C)Parenteral route
D)Tr

Question 7

When the solvent in association with the drug is water, the solvate is known as

A)anhydrate
B)amorphous
C)hydrate
D)none of the above

Question 8

………….is used to study gastric emptying.

A)Barium sulphate
B)Aluminum sulphate
C)Calcium sulphate
D)Aluminum hydroxide

Question 9

The main mechanism of most drugs absorption in GI tract is:

A)Active transport (carrier-mediated diffusion)
B)Filtration (aqueous diffusion)
C)Endocytosis and exocytosis
D)Passive diffusion (lipid diffusion)

Question 10

Pick out the appropriate alimentary route of administration when passage of drugs through liver is minimized:

A)Oral
B)Transdermal
C)Rectal
D)Intraduodenal

Question 11

What is characteristic of the oral route?

A)Fast onset of effect
B)Absorption depends on GI tract secretion and motor function
C)A drug reaches the blood passing the liver
D)The sterilization of medicinal forms is obligatory

Question 12

Tick the feature of the sublingual route:

A)Pretty fast absorption
B)A drug is exposed to gastric secretion
C)A drug is exposed more prominent liver metabolism
D)A drug can be administered in a variety of doses

Question 13

Pick out the parenteral route of medicinal agent administration:

A)Rectal
B)Oral
C)Sublingual
D)Inhalation

Question 14

Parenteral administration:

A)Cannot be used with unconsciousness patients
B)Generally results in a less accurate dosage than oral administration
C)Usually produces a more rapid response than oral administration
D)Is too slow for emergency use

Question 15

What is characteristic of the intramuscular route of drug administration?

A)Only water solutions can be injected
B)Oily solutions can be injected
C)Opportunity of hypertonic solution injections
D)The action develops slower, than at oral administration

Question 16

All are characteristics of passive diffusion except

A)Drugs moves down the concentration gradient.
B)It is an energy independent process
C)Drugs moves up the concentration gradient.
D)It is non saturable process

Question 17

Passive diffusion is expressed by

A)Fick's first law of diffusion
B)Fick's second law of diffusion
C)First order kinetics
D)zero order kinetics

Question 18

Aqueous filled pores present in cell membrane responsible for absorption of

A)water insoluble molecules
B)water soluble molecules
C)both (a) and (b)
D)None of the above

Question 19

What kind of substances cannot permeate membranes by passive diffusion?

A)Lipid-soluble
B)Non-ionized substances
C)Hydrophobic substances
D)Hydrophilic substances

Question 20

A hydrophilic medicinal agent has the following property:

A)Low ability to penetrate through the cell membrane lipids
B)Penetrate through membranes by means of endocytosis
C)Easy permeation through the blood-brain barrier
D)High reabsorption in renal tubules

Question 21

What is implied by active transport?

A)Transport of drugs through a membrane by means of diffusion
B)Transport without energy consumption
C)Engulf of drug by a cell membrane with a new vesicle formation

Question 22

The rate of diffusion of drug across biological membrane is

A)Directly proportional to the concentration gradients
B)Dependant on route of administration
C)Indirectly proportional to membrane thickness
D)None of the above

Question 23

Absorption of griseofulvin is……………

A)Dissolution rate limited
B)Permeation rate limited
C)Perfusion rate limited
D)None of the above

Question 24

Micronized form of drug absorbed fast because

A)surface area increased
B)viscosity increased
C)angle of distribution increased
D)none of the above

Question 25

…………form of weakly acidic drug absorbed well in stomach

A)ionized
B)unionised
C)both
D)none of the above