Deck 6: Exploring Drug Formulation and Delivery: Membrane Permeability, Tablet Disintegration, and Excipient Selection

Question 1

Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?

A)Polar head
B)Hydrophobic head
C)Hydrophobic core
D)Non polar head

Answer 1

Hydrophobic core

Question 2

What helps in the passing of inorganic ions?

A)Ion channels
B)Voltage gated channels
C)Aqueous filled pores
D)Diffusion

Answer 2

Aqueous filled pores

Question 3

The cell membrane is ___________

A)Impermeable
B)Semipermeable
C)Permeable
D)Permeable to only gases

Answer 3

Permeable

Question 4

What is the most important characteristic of a drug to be absorbed after oral administration?

A)Dissolved in HCL
B)Dissolved in alkaline solution
C)Can pass through the cell membrane
D)Form aggregate and settle down

Question 5

Cell membrane can pass easily Oxygen and Carbon dioxide.

A)False
B)True
C)none
D)all

Question 6

Which one of these is an example of Enteral Route?

A)Skin
B)IV
C)Gastrointestinal
D)Inhalation

Question 7

Gastrointestinal route is an example of which of the major drug delivery routes?

A)The enteral route
B)The parenteral route
C)The topical route
D)The intravenous route

Question 8

Which form of drug formulation has disintegration time?

A)Injections
B)Syrups
C)Capsules and Tablets
D)Only tablets

Question 9

Which tablets have longer Disintegration time?

A)Single coated tablets
B)Uncoated tablets
C)Sugar-coated tablets
D)Capsules

Question 10

Disintegration time is directly proportional to the amount of binder present in the tablet.

A)True
B)False
C)none
D)all

Question 11

Which of the following is not a form of excipients?

A)Paracetamol
B)Disintegrants
C)Lubricants
D)Binders

Question 12

Which of the following is not a limitation granulation?

A)Formation of crystal bridge by the presence of liquid
B)The liquid may act as a medium for affecting chemical reactions such as hydrolysis
C)Increase the cost due to more additional processing
D)The drying step may harm the thermolabile drugs

Question 13

The agglomerative phase of the communication method grinds the drug in a ball mill for a long time to affect spontaneous agglomeration. But results showed tablets produced are softer.

A)True
B)False
C)none
D)all

Question 14

Which of these is not a characteristic of tablet formulation by Agglomerative phase of the communication process?

A)Tablets are stronger
B)Usage of more binding agent
C)Rapid dissolution
D)Increase in internal surface area of the granules

Question 15

What does the graph of Rate of Drug dissolution v/s Compression force with this type of curve interpret?

A)Tight binding of the molecules in drug
B)Deformation of the drug particles into smaller particles
C)The influence of compression force on the dissolution rate is difficult
D)Both tight bonding and deformation of the drug molecules

Question 16

What does the graph of Rate of Drug dissolution v/s Compression force with this type of curve interpret?

A)Tight binding of the molecules in drug
B)Deformation of the drug particles into smaller particles
C)The influence of compression force on the dissolution rate is difficult
D)Both tight bonding and deformation of the drug molecules

Question 17

Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size.

A)True
B)False
C)none
D)all

Question 18

Which one of them is not a common form of excipients of drug manufacturing?

A)Diluents
B)Binders
C)Sweeteners
D)Essential oils

Question 19

Vehicles are the solvent system for the liquefied drug. Which one of them is not an example of a kind of vehicle?

A)Aqueous vehicle
B)Non-aqueous water-miscible vehicles
C)Non-aqueous water immiscible vehicles
D)A salt solution of the drug

Question 20

Which one of the following will be an example of organic diluents?

A)Starch
B)Dicalcium phosphate
C)Tetracycline
D)Tween 80

Question 21

What is the function of a granulating agent in drug formulation?

A)Promote cohesive compacts
B)Added if the required dosage is inadequate so that necessary bulk can be produced
C)Tablets can disintegrate easily
D)Used as solubilizer

Question 22

What is the full form of PVP and what is its function in drug formation?

A)Polyvinyl propylene, diluent
B)Polyvinyl pyrrolidine, solubilizing agent
C)Polyvinyl propylene, buffering agent
D)Polyvinyl pyrrolidine, Binding agent

Question 23

Which one of the following sentences depicts the function of Disintegrants correctly?

A)These agents help in holding the powders together to form granules
B)These agents overcome the cohesive strength of the tablets and help in dissolution
C)These agents help in the flow of granules and reduce friction between particles
D)Added when the required dosage is inadequate

Question 24

A large amount of binders tends to increase the hardness of tablets.

A)True
B)False
C)none
D)all

Question 25

An example of lubricants will be __________

A)PVP
B)Carbowaxes
C)CMC
D)Tetracycline