Deck 8: Pharmacokinetics and the Digestive System

Question 1

Acidic drugs are best absorbed through the stomach and basic drugs are best absorbed through the intestine.

A)True
B)False
C)none
D)all

Answer 1

True

Question 2

What could be the reason that irrespective of pH any drug gets absorbed mostly from the intestine?

A)More surface area
B)Long residence time
C)Large surface area and long residence time
D)Large surface area, long residence time, basic pH

Answer 2

Large surface area and long residence time

Question 3

Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.

A)True
B)False
C)none
D)all

Answer 3

False

Question 4

What are the major stability problems which result in poor bioavailability of any orally administered drugs?

A)Acidic degradation
B)Degradation by salivary amylase
C)Degradation of the drug in inactive form
D)Interaction with the excipients and degradation in an inactive form

Question 5

What is the mean length of GIT?

A)350 cm
B)200cm
C)400cm
D)450cm

Question 6

The entire length of the GI is lined by ___________

A)Blood vessels
B)Nerves
C)Mucopolysaccharides
D)No lining direct contact with the cell

Question 7

Which drugs get absorbed in the stomach mostly?

A)Basic drugs
B)Acidic Drugs
C)Neutral drugs
D)No drug gets absorbed in the stomach

Question 8

Which drugs gets mostly absorbed from the mouth?

A)Acidic drugs and lipophilic drugs
B)Lipophilic drugs and neutral drugs
C)Neutral drugs and lipophilic drugs
D)Lipophilic, neutral, basic drugs

Question 9

From the surface of villi protrude smaller projection known as __________

A)Microvilli
B)Villus
C)Fingers
D)Cilia

Question 10

Which of the following sentences will be the actual definition of folds of Kerckring?

A)Folds of the intestinal mucosa
B)Finger-like projections whose other name is villi
C)Protruding surface from the villi
D)Cilia over the surface of villi

Question 11

Which one of the following is not a characteristic for the small intestine?

A)Peristaltic movement
B)Long transit time
C)High permeability
D)PH 4-9

Question 12

How can we increase the time of gastric emptying?

A)By drinking a lot of water
B)By taking a drug in empty stomach
C)By taking the drug after food
D)Cannot increase the time of gastric emptying at all

Question 13

What is gastric emptying rate?

A)The time required for the gastric contents to empty into the small intestine
B)Time is taken for half of the contents in the stomach to empty
C)The speed at which the stomach contents empty into the intestine
D)There is no such term

Question 14

How can we study the gastric emptying of a given drug?

A)By mixing the colour with the drug
B)Waiting for the subject man to throw-up
C)Tagging the drug with a radioisotope and scanning the stomach
D)Waiting for the patient to pass feces

Question 15

Up to how much the microvilli in the small intestine increases the relative surface area of the small intestine?

A)3 times
B)30 times
C)100 times
D)600 times

Question 16

The liver is the major site of drug metabolism.

A)True
B)False
C)none
D)all

Question 17

In infants, the gastric pH is quite low.

A)True
B)False
C)none
D)all

Question 18

The passage from the stomach to the small intestine is called gastric emptying.

A)True
B)False
C)none
D)all

Question 19

Which one is the sublingual route?

A)Drug placed between cheek and gum
B)Drug place between the tongue and upper palate
C)Drug placed under the tongue
D)Drug crushed and placed under the tongue

Question 20

Which one of the following is the buccal route?

A)Drug placed between cheek and gum
B)Drug place between the tongue and upper palate
C)Drug placed under the tongue
D)Drug crushed and placed under the tongue

Question 21

Which one of the following is not an advantage of sublingual or buccal administration?

A)Rapid absorption and higher blood levels
B)No first-pass hepatic metabolism
C)No degradation of drugs
D)Limited surface area

Question 22

What is the principal barrier for the drugs on the topical application?

A)The Dermis
B)The subcutaneous fat tissue
C)The stratum corneum
D)The blood vessels below the skin

Question 23

Which of the following decreasing order of blood flow rate through the muscular tissue is in the right order?

A)Arm > thigh > buttocks
B)Arm > buttocks > thigh
C)Buttocks > thigh > arm
D)Thigh > arm > buttocks