Deck 10: Pharmacokinetics and Drug Binding: Understanding Drug Distribution and Transport Across Membranes

Question 1

……………is located at the sertoli-sertoli cell junction.

A)Blood testis barrier
B)Blood CSF barrier
C)Blood cellular barrier
D)All of the above

Answer 1

Blood testis barrier

Question 2

The Binding Order of drug to tissue is…………………

A)Kidney > Liver > Lungs > Muscle
B)Muscle > Kidney > Lungs > Liver
C)Liver > Kidney > Lungs > Muscle
D)Liver > Lungs > Kidney > Muscle

Answer 2

Liver > Kidney > Lungs > Muscle

Question 3

…………………in lipophilicity increases the extend of binding.

A)Increase
B)Decrease
C)Constant
D)None of the above

Answer 3

Increase

Question 4

Protein binding of drugs helps to maintain ……………for absorption of drugs.

A)non sink condition
B)sink condition
C)pKa
D)none of the above

Question 5

The loading dose of a drug is based upon the

A)time taken for complete elimination
B)percentage of drug excreted unchanged in urine
C)percentage of drug bound to plasma protein
D)apparent volume of distribution and the desired drug concentration in plasma

Question 6

The volume of distribution of drugs is:

A)An expression of total body volume
B)A measure of total fluid volume
C)A relationship between the total amount of drug in the body and the concentration of the drug in the blood
D)Proportional to bioavailability of the drug

Question 7

The volume of distribution (Vd) relates:

A)Single to a daily dose of an administered drug
B)An administered dose to a body weight
C)An unchanged drug reaching the systemic circulation
D)The amount of a drug in the body to the concentration of a drug in plasma

Question 8

Movement of drug across the membrane is called as

A)Symport
B)Antiport
C)Drug transport
D)Absorption

Question 9

Which of the following is known as Tamoxifen binding site?

A)Site I
B)Site II
C)Site III
D)Site IV

Question 10

Which of the following drug selectively bound to extravascular tissues?

A)Warfarin
B)Diazepam
C)Digitoxin
D)Chloroquin

Question 11

Plasma Protein binding …………..the volume of distribution of drugs.

A)increases
B)decreases
C)no change
D)none of the above

Question 12

Following intravenous administration, drugs are distributed fastest to:

A)the skin, kidney, and brain
B)the liver, kidney, and brain
C)the liver, adipose, and brain
D)the liver, kidney, and adipose

Question 13

…………is the tight junction between sertoli cells.

A)BBB
B)placental barrier
C)blood-testis barrier
D)endothelial barrier

Question 14

Distribution is……………..

A)irreversible process
B)dynamic equilibrium process
C)Both (a) & (b)
D)none of the above

Question 15

A drug reverses plasma-protein binding is often referred as……..

A)displacer
B)solvate
C)carrier substance
D)protein hydrolysate

Question 16

Primary binding site for albumin is ………………binding site.

A)Warfarin
B)Diazepam
C)Digitoxin
D)Tamoxifen

Question 17

Which of the following strategies are widely used to improve or promote transport of drug to brain?

A)Glycosylation
B)Use of Mannitol
C)Prodrug approach
D)All of the above

Question 18

Acidic drug have

A)Low Vd
B)high Vd
C)No Vd
D)none of the above

Question 19

Low molecular weight of drugs have

A)Low Vd
B)high Vd
C)No Vd
D)none of the above

Question 20

Water soluble drugs have

A)Low Vd
B)high Vd
C)No Vd
D)none of the above

Question 21

Lipid soluble drugs have

A)Low Vd
B)high Vd
C)No Vd
D)none of the above

Question 22

Protein binding ……………the distribution of drugs.

A)Decreases
B)Increases
C)No Change
D)none of the above

Question 23

Which one of the following physicochemical property is more important for passive diffusion of drugs from the GIT?

A)Partition coefficient
B)Lipid solubility
C)pH of GIT fluids
D)dissolution constant

Question 24

Drug permeation through BBB can be improved by………..

A)Glycosylation
B)Mannitol
C)Dihydropyridine redox system
D)all of the above

Question 25

Which of the following drug diffuses readily into the brain?

A)Penicillin
B)Thiopental
C)Dopamine
D)all of the above