Deck 11: Drug Distribution and Barrier Permeability in the Body

Question 1

Drug distribution in an organ depends on…………

A)Organ size
B)Perfusion rate
C)Partition Coefficient
D)all of the above

Answer 1

all of the above

Question 2

Protein binding of acidic drugs decreased in………..

A)Trauma
B)Surgery
C)Hepatic Cirrhosis
D)Burns

Answer 2

Trauma

Question 3

Which one of the following sentences will be the actual definition of distribution?

A)Transfer of drug from the administration dosage to surrounding fluid
B)Transfer of drug from the surrounding the fluid to the blood
C)Transfer of the drug from the oral cavity to the intestine
D)Reversible tr

Answer 3

Reversible tr

Question 4

What should be the molecular weight of the drug molecules so that they can easily pass through the membrane?

A)600-800 Dalton
B)500-600 Dalton
C)300-500 Dalton
D)200-400 Dalton

Question 5

Which type of drug cannot enter the cell membrane in the below picture?

A)Ionized drug
B)Unionized drug
C)Hydrolyzed drug
D)Unhydrated drug

Question 6

Which drugs cannot pass the Capillary endothelial Barrier?

A)Molecular size less than 600 Dalton
B)Drugs bound to blood components
C)Drugs bound to a chemical moiety
D)All drugs can pass

Question 7

Which of the following drug cannot pass through the plasma membrane barrier?

A)Drug size less than 50 Dalton
B)Lipophilic drugs 50-600 Dalton
C)Polar or ionized drugs of size greater than 50 Dalton
D)Drug size more than 600 Dalton

Question 8

Which cell make up the blood-brain barrier?

A)Squamous epithelium cells
B)Fat cells
C)Red blood cell
D)Endothelial cells

Question 9

What is the name of the specialized cells that support the blood-brain barrier tissue?

A)Astrocytes
B)Dendrites
C)Fat cells
D)Endothelial cells

Question 10

Why dopamine cannot be administered for the disease Parkinsonism?

A)Don't have a medicine
B)It is not the medicine
C)Cannot cross the blood-brain barrier
D)Forms aggregate and thus cannot cross the BBB

Question 11

Which one of these is not an approach to make the drug cross the blood-brain barrier?

A)Using permeation enhancers
B)Osmotic disruption of the blood-brain barrier
C)Use of highly lipophilic drug only
D)Use of drug carriers to cross the BBB

Question 12

Which drugs can easily pass the Placental barrier?

A)Drugs having a molecular weight less than 1000 Dalton
B)Moderate to high lipid solubility
C)Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics
D)Analgesics, antibiotics, etc

Question 13

What is the function of the blood-testis barrier?

A)Restricts the passage of drug to the testis
B)Restricts the passage of drug to sperms
C)Restricts the passage of drugs to spermatocytes
D)Restricts the passage of drugs to spermatocytes and spermatids

Question 14

What is the perfusion rate?

A)The total volume of blood
B)The volume of blood that flows through the heart per unit time
C)The volume of blood that flows per unit time per unit volume of tissue
D)The volume of tissue that flows per unit time per unit area of a blood vessel

Question 15

Who has more intracellular and extracellular water more in their body?

A)Aged
B)Adults Of age more than 20
C)Infants
D)Children at puberty

Question 16

Who has higher fat content?

A)Adults of age above 70
B)Adults of age more than 20
C)Infants and elders
D)Children at puberty

Question 17

Who has poorly developed BBB?

A)Infants
B)Adults Of age more than 20
C)Aged
D)Children at puberty

Question 18

During pregnancy, drug distribution is more. Which of the following sentences describe the given fact better?

A)The baby needs more drug
B)The mother needs more drug due to high metabolism
C)The surface area increases in the mother's body due to the presence of uterus, placenta, and foetus. Thus more area for distribution of drugs
D)The growth of the uterus, placenta, and foetus increases the volume thus increasing distribution. And even the baby forms a separate compartment for a drug to get distributed

Question 19

What happens when an obese person is given with a lipophilic drug?

A)Drug aggregation will begin
B)He cannot absorb lipophilic drugs
C)High adipose tissue take up most of the lipophilic drug
D)A large amount of drug is needed as the person's weight is more

Question 20

What is the consequence of diet high in fats?

A)The patient can't be given with acidic drugs
B)The patient can't be given with basic drugs
C)The basic drugs will aggregate and become poisonous for him
D)The high fatty acid level affect the binding of acidic drugs

Question 21

The extent to which a drug is distributed is a tissue depends upon ___________ and _____________

A)The concentration of a drug, tissue/blood partition coefficient of drug
B)Tissue volume, tissue/blood partition coefficient of drug
C)Tissue surface area, tissue/blood partition coefficient of drug
D)Blood density upon the tissue, tissue/blood partition coefficient of drug

Question 22

Which one of the following has a high perfusion rate?

A)Fat
B)Muscle and skin
C)Lungs and kidney
D)Bone

Question 23

Which one of the following has very low perfusion rate?

A)Fat and bone
B)Muscle and skin
C)Lungs and kidney
D)Liver and Heart

Question 24

Infants have high albumin content.

A)True
B)False
C)none
D)all

Question 25

Disease state of a patient can influence drug distribution across the body.

A)True
B)False
C)none
D)all