Deck 13: Protein-Drug Binding and Interactions: Exploring Factors and Mechanisms

Question 1

Which vitamin molecules will bind to alpha 2 globulin?

A)Vitamin b complexes
B)Vitamin a and vitamin b
C)Vitamin A, D, E, K
D)Steroids bind to alpha 2 globulin, not vitamin

Answer 1

Vitamin A, D, E, K

Question 2

What is the molecular weight of human serum albumin?

A)5000 Dalton
B)65,000 Dalton
C)60,000 Dalton
D)75,000 Dalton

Answer 2

65,000 Dalton

Question 3

HSA comes under which protein family?

A)Globulin
B)Receptor
C)Enzymes
D)Catalyst

Answer 3

Receptor

Question 4

What is the name of the drug binding site I of HSA?

A)Tamoxifen binding site
B)Digitoxin binding site
C)Diazepam binding site
D)Warfarin and azapropazone binding site

Question 5

Which one of the below does not belong to the 4 classes of lipoprotein?

A)Chylomicrons
B)Very low-density lipoproteins
C)High-density lipoprotein
D)Fatty acids

Question 6

Which of the given drugs bind to ?1 globulin?

A)Steroidal drugs
B)Vitamins A, D, E, K
C)Ferrous ions
D)Carotenoids

Question 7

What is the name of the drug binding site IV of HSA?

A)Tamoxifen binding site
B)Digitoxin binding site
C)Diazepam binding site
D)Warfarin and azapropazone binding site

Question 8

Acidic drugs like imipramine, lidocaine bind to alpha 1 Acid Glycoprotein.

A)True
B)False
C)none
D)all

Question 9

Which of the given drugs bind to ?2 globulin?

A)Steroidal drugs
B)Vitamins A, D, E, K
C)Ferrous ions
D)Carotenoids

Question 10

What is the name of the drug binding site III of HSA?

A)Tamoxifen binding site
B)Digitoxin binding site
C)Diazepam binding site
D)Warfarin and azapropazone binding site

Question 11

Which drugs bind to RBC membrane?

A)Pentobarbital
B)Acetazolamide
C)Imipramine
D)Phenytoin

Question 12

What is the name of the drug binding site II of HSA?

A)Tamoxifen binding site
B)Digitoxin binding site
C)Diazepam binding site
D)Warfarin and azapropazone binding site

Question 13

Which one of the following factors related to protein-drug binding is not related to drugs?

A)Physicochemical characteristics of a drug
B)The concentration of the drug in the body
C)The affinity of the drug for binding
D)Number of binding sites on the binding agent

Question 14

Which one of the following factor related to protein-drug binding is not related to drug interactions with the binding site?

A)Competition between the drug and the binding site
B)Competition between drugs and normal body constituents
C)Allosteric changes in a protein molecule
D)Inter subject variation

Question 15

Which of the following factors for protein drug binding is a drug interaction factor?

A)Competition between drugs for the binding site
B)Age
C)Physicochemical characteristics of a drug
D)Physicochemical characteristics of the protein or binding agent

Question 16

Which drugs bind to HSA easily?

A)Cationic drug
B)Anionic drug
C)Lipophilic drug
D)Neutral drug

Question 17

Which drugs easily bind to adipose tissue?

A)Cationic drug
B)Anionic drug
C)Lipophilic drug
D)Neutral drug

Question 18

Which drug easily bind to AAG?

A)Cationic drug
B)Anionic drug
C)Lipophilic drug
D)Neutral drug

Question 19

The extent of drug-protein binding can change with both changes in protein and drug concentration.

A)True
B)False
C)none
D)all

Question 20

In the equation X= Vd C, what does X stands for?

A)Amount of drug in the blood
B)Amount of drug in plasma
C)Amount of drug in the tablet
D)Amount of drug in the body

Question 21

Only unbound or free drug is capable of being eliminated.

A)True
B)False
C)none
D)all

Question 22

Penicillin has short plasma half-life although it can bind to plasma protein rigidly.

A)True
B)False
C)none
D)all

Question 23

Displacement interactions are significant in the case of drugs which are more than 95% bound.

A)True
B)False
C)none
D)all

Question 24

Which of the following is a correct method to find the fraction of unbound drug in plasma? Given where Cu is the concentration of unbound drug and C is total plasma drug concentration.

A)CuC
B)C / Cu
C)Cu/C
D)1/C Cu

Question 25

The value of association constant, Ka and the number of binding sites N can be obtained by

A)Direct plot
B)Scatchard plot
C)Klotz plot
D)All of the above