Deck 17: Bioavailability and Drug Absorption

Question 1

What is the driving force for glomerular filtration?

A)Concentration gradient
B)Hydrostatic pressure of plasma
C)High amount of aqueous pores
D)Hydrostatic pressure of blood flow

Answer 1

Hydrostatic pressure of blood flow

Question 2

Which of the following compounds are used as agents to determine Glomerular Filtration Rate?

A)Calcium ion
B)Albumin
C)Creatinine
D)Calcium carbonate

Answer 2

Creatinine

Question 3

According to Biopharmaceutics Classification System (BCS), Class II drugs have

A)High solubility/High permeability
B)Low solubility /High permeability
C)High solubility /Low permeability
D)Low solubility /Low permeability

Answer 3

Low solubility /High permeability

Question 4

………………is the ratio of the mean residence time to the absorption time

A)Absorption number
B)Dissolution number
C)Dose number
D)Intrinsic dissolution

Question 5

USP Apparatus 5 is

A)Flow-through- cell
B)paddle over disk
C)Cylinder
D)Paddle

Question 6

In vitro dissolution rate studies on drug product are useful in bioavailability evaluation if they are correlated with

A)Disintegration rate
B)In vivo studies in at least 3 species of animals
C)Chemical stability of drugs
D)In vivo studies in human

Question 7

The gold coating on a USP Dissolution apparatus - I basket should be:

A)Not more than 2.5 m in thickness
B)Not more than 0.1 mm in thickness
C)Not more than 0.025 m in thickness
D)Not more than 0.22 mm in thickness

Question 8

Which of the following is initial step for drug absorption in case of tablet dosage form?

A)Friability
B)Disintegration
C)Dissolution
D)None of these

Question 9

Under the concept biopharmaceutics, hydrophobic drugs are

A)Permeation rate limited
B)Dissolution rate limited
C)Both
D)Initially permeation then dissolution rate limited

Question 10

When a drug is administered by the intravenous route then an absolute bioavailability will be

A)1
B)0
C)2
D)3

Question 11

Which of the following methods are used to determine Area Under curve?

A)Cut and weigh method
B)Trapezoidal method
C)Integration method
D)All of the above

Question 12

Apparatus 5 of dissolution apparatus is known as

A)Paddle over disk
B)Flow-through- cell
C)Reciprocating disk
D)Basket

Question 13

Bioavailability differences among oral formulations of a drug are most likely to occur if the drug

A)Is freely water soluble
B)Is completely absorbed
C)Is incompletely absorbed
D)Undergoes little first-pass metabolism

Question 14

Bioavailability is expressed by formula

A)AUC IV / AUC oral
B)AUC ora1 X AUC IV
C)AUC ora1 / AUC IV
D)None of the above

Question 15

The comparison of bioavailability between two dosage forms.

A)Bioequivalence
B)Bioavailability
C)Biopharmaceutics
D)Biological

Question 16

The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs.

A)Biological
B)Bioavailability
C)Biopharmaceutics
D)Bioequivalency

Question 17

Bioavailability of an intravenous drug is always 100% by definition because:

A)Bioavailability measures the amount of substance that reaches the bloodstream.
B)Absolute bioavailability is 50%, for any drug taken intravenously
C)Absolute bioavailability is a much more important measure than relative bioavailability
D)Intravenous administration gets the drug into your bloodstream the fastest.

Question 18

Comparison of the rate and extent of the absorption of drug from the formulation under study to the data of a reference standard that is given intravenously is known as:

A)Biopharmaceutics
B)Relative bioavailability
C)Absolute bioavailability
D)Bioavailability

Question 19

If the Relative Bioavailability is 1, it indicates:

A)Bioavailability of dosage form of one drug is same as that of the other dosage form
B)Complete binding of the drugs to the proteins as compared to the standard drug
C)Complete bioavailability of the drug
D)Complete distribution of the drug

Question 20

What would be the order of greater or lesser bioavailability of the dosage forms?

A)Intravenous > rectal > oral > topical
B)Intravenous > oral > rectal > topical
C)Intravenous > topical > rectal > oral
D)Oral > intravenous > rectal > topical

Question 21

…………decreases bioavailability of tetracycline.

A)Lactose
B)DCP
C)Starch
D)MCC

Question 22

The term bioavailability refers to the………….

A)relationship between the physical and chemical properties of a drug and the systemic absorption of the drug
B)measurement of the rate and amount of therapeutically active drug that reaches the systemic circulation
C)movement of drug into the body tissues over time
D)dissolution of a drug in the gastrointestinal tract

Question 23

The reasons determining bioavailability are…..

A)Rheological parameters of blood
B)Amount of a substance obtained orally and quantity of intakes
C)Extent of absorption and hepatic first-pass effect
D)Glomerular filtration rate

Question 24

Bioavailability is defined as…..

A)Rate of drug absorption
B)Rate of drug distribution
C)Rate of drug elimination
D)Rate and extent of absorption

Question 25

The rate of drug bioavailability is most rapid when the drug is formulated as a…..

A)controlled released product
B)hard gelatin capsule
C)tablet
D)solution