Deck 18: Bioavailability Studies and Related Concepts

Question 1

The drug concentration between MEC and MSC represents the….

A)Therapeutic Index
B)Therapeutic range
C)Therapeutic outcome
D)Therapeutic ratio

Answer 1

Therapeutic range

Question 2

Dissolution test apparatus I as per IP is…..

A)Paddle
B)Basket
C)Rotating basket
D)Rotating paddle

Answer 2

Paddle

Question 3

Non-invasive measurement of drug concentration includes ……….sampling.

A)hair
B)urine
C)saliva
D)All of the above

Answer 3

All of the above

Question 4

Ex-vivo models refer to…….

A)in the body
B)in the computer
C)outside the body
D)none of the above

Question 5

USP dissolution test apparatus type-II is also called as…..

A)Hansen paddle type
B)paddle over disc
C)Rotating basket type
D)none of the above

Question 6

Bioavailability from IV route is……%

A)10
B)100
C)1000
D)10000

Question 7

Bioavailability of drug from topical administration is affected by…..

A)Skin condition
B)Topical vehicle
C)Application condition
D)all of the above

Question 8

What is bioavailability?

A)The time of absorption of the drug from its dosage form
B)The rate of absorption of the unchanged drug from its dosage form
C)The time of absorption of the unchanged drug from its dosage form
D)The rate of absorption of the drug from its dosage form

Question 9

What is the equation of bioavailable fraction?

A)1/Bioavailable dose
B)1/Administered dose
C)Bioavailable dose/Administered dose
D)Administered dose/Bioavailable dose

Question 10

Which of the following is not an objective of bioavailability studies?

A)Primary stages of development of suitable dosage form for new drug
B)Determination of the influence of excipients, patient-related factors, etc
C)Development of new formulations of the existing drugs
D)Control the quantity of the drug to be administered

Question 11

Single-dose bioavailability studies are simple and common.

A)True
B)False
C)none
D)all

Question 12

Multiple dose study is better since we can understand the peak, valley, drug blood levels, etc.

A)True
B)False
C)none
D)all

Question 13

Which of the following is the pharmacodynamics method of studying bioavailability?

A)Acute pharmacologic response
B)Plasma-level time studies
C)Urinary excretion studies
D)Stool excretion studies

Question 14

Which of the following is not an important parameter of plasma level time studies?

A)Cmax
B)Tax
C)The area under the plasma level-time curve
D)Steady state level

Question 15

What is the equation for bioavailability?

A)[AUC]std Dstd ?test / [AUC]test Dtest ?std
B)[AUC]test Dtest ?std / [AUC]std Dstd ?test
C)[AUC]test Dstd ?test / [AUC]std Dtest ?std
D)1 / [AUC]std Dtest ?std

Question 16

The urinary excretion of the unchanged drug is directly proportional to the plasma concentration of a drug.

A)True
B)False
C)none
D)all

Question 17

Which of the following will not be a parameter that should be examined for urinary excretion data?

A)(dXu/dt) max
B)(tu)max
C)Xu
D)Cmax

Question 18

Which of the following is not measured in acute pharmacological response study?

A)ECG
B)EEG
C)Pupil diameter
D)Serum drug level

Question 19

Therapeutic response is based on observing the clinical response to a drug formulation.

A)True
B)False
C)none
D)all

Question 20

In vitro determination of bioavailability by dissolution rate is not the best way to determine therapeutic efficacy.

A)True
B)False
C)none
D)all

Question 21

The time period for which the plasma concentration of drug remains above minimum effective concentration is known as ______________

A)Onset of time
B)Onset of action
C)Duration of drug of action
D)Therapeutic range

Question 22

Poor bioavailability means poor aqueous solubility.

A)True
B)False
C)none
D)all

Question 23

A drug with poor stability means higher bioavailability.

A)True
B)False
C)none
D)all

Question 24

Which of the following is not an approach for overcoming bioavailability problems?

A)Pharmaceutic approach
B)Pharmacokinetic approach
C)Biologic approach
D)Partition coefficient approach

Question 25

What will be the particle size after micronization of drugs?

A)1-10 micron
B)10-20 micron
C)20-30 micron
D)1-5 micron