Deck 22: Pharmacokinetics and Dosage Regimen

Question 1

The ratio of maximum safe concentration to minimum effective concentration is called as

A)Therapeutic index
B)Therapeutic range
C)Therapeutic outcome
D)Therapeutic ratio

Answer 1

Therapeutic index

Question 2

Half life of zero-order process is proportional to of drug.

A)initial concentration
B)final concentration
C)both (a) & (b)
D)none of the above

Answer 2

initial concentration

Question 3

The ability of liver to excrete drug in bile is expressed by………

A)hepatic clearance
B)biliary clearance
C)non-renal clearance
D)renal clearance

Answer 3

biliary clearance

Question 4

…………..is nothing but manner in which drug should be taken.

A)dosing frequency
B)dosage regimen
C)dose adjustment
D)none of the above

Question 5

What is dosage regimen?

A)The concentration of active agent in the drug formulation
B)The manner in which the drug is given to old people
C)The manner in which a drug is taken
D)The manner in which drug given to child

Question 6

What is optimal multiple dosage regimen?

A)The concentration of active agent in the drug formulation
B)Dosage which maintains the plasma concentration within the therapeutic window.
C)The manner in which a drug is taken
D)The manner in which drug given to child

Question 7

On what basis the dose interval is calculated?

A)Active drug concentration in the formulation
B)Half-life of the drug
C)Duration of the disease
D)Age of the patient

Question 8

What is fluctuation?

A)Cmax/Cmin
B)Cmin / Cmax
C)1/Cmin
D)1/Cmax

Question 9

How do you calculate the ideal body weight for men?

A)50 kg +- 1kg/2.5cm above or below 150 cm in height
B)45 kg +- 1kg/2.5cm above or below 150 cm in height
C)40 kg +- 1kg/2.5cm above or below 150 cm in height
D)35 kg +- 1kg/2.5cm above or below 150 cm in height

Question 10

How do you calculate the ideal body weight for a woman?

A)50 kg +- 1kg/2.5cm above or below 150 cm in height
B)45 kg +- 1kg/2.5cm above or below 150 cm in height
C)40 kg +- 1kg/2.5cm above or below 150 cm in height
D)35 kg +- 1kg/2.5cm above or below 150 cm in height

Question 11

Which of the following drugs are lipid soluble?

A)Phenytoin
B)Caffeine
C)Digoxin
D)Antibiotics

Question 12

Which of the following drugs get distributed to the same extent in both lean and adipose tissue?

A)Phenytoin
B)Caffeine
C)Digoxin
D)Antibiotics

Question 13

Which of the following drugs can get distributed to the excess body space of obese patient?

A)Phenytoin
B)Caffeine
C)Digoxin
D)Antibiotics

Question 14

Which of the following drug can get distributed in the excess body space?

A)Phenytoin
B)Caffeine
C)Digoxin
D)Antibiotics

Question 15

Neonates, infants and children require different dosages than adults.

A)True
B)False
C)none
D)all

Question 16

Accumulation occurs because drug from previous doses was not being removed completely.

A)True
B)False
C)none
D)all

Question 17

The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.

A)True
B)False
C)none
D)all

Question 18

Which of the following promotes excretion of acidic drugs?

A)Citrates
B)Ammonium chloride
C)Methionine
D)Ascorbic acid

Question 19

Which of the following promotes the excretion of basic drugs?

A)Tartarates
B)Citrates
C)Bicarbonates
D)Ammonium chloride

Question 20

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = 0.48 H / Scr *[W/70]0.7 formula belong to?

A)1-6 years
B)1-20 years
C)Males above 20 years
D)Females above 20 years

Question 21

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 - Age) W / 72 * Scr formula belong to?

A)1-6 years
B)1-20 years
C)Males above 20 years
D)Females above 20 years

Question 22

This is the equation for the calculation of creatinine clearance. Which age group does the Clcr = (140 - Age) W / 85 * Scr formula belong to?

A)1-6 years
B)1-20 years
C)Males above 20 years
D)Females above 20 years

Question 23

A girl with age 21 has height 240cm, weight 55kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.

A)80 ml/min
B)90 ml/min
C)96.25 ml/min
D)85 ml/min

Question 24

An adult male with age 22 has height 240cm, weight 85kg, serum creatinine of 0.8mg will have ______________ creatinine clearance.

A)150 ml/min
B)160 ml/min
C)170.13 ml/min
D)174.131 ml/min

Question 25

Which creatinine clearance value shows moderate renal failure?

A)120-130 ml/min
B)20-50 ml/min
C)Below 10 ml/min
D)70-80 ml/min