Question 1

Glucose entry into the cells of the following organ/tissue is highly dependent on the presence of insulin:&#10;A)Brain&#10;B)Liver&#10;C)Adipose tissue&#10;D)Kidney tubules

Accepted Answer

Adipose tissue requires insulin for glucose uptake, unlike the brain, liver, and kidney tubules, which can take up glucose independently of insulin.

Question 2

Clofibrate is synthesized from&#10;A)o-chloro phenol&#10;B)m-chloro phenol&#10;C)p-chloro phenol&#10;D)3,4, -dichloro phenol

Accepted Answer

Clofibrate is synthesized from p-chloro phenol, which is used as a starting material in its chemical synthesis process.

Question 3

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide is IUPAC name of&#10;A)Hydrochlorthiazide&#10;B)Acetazolamide&#10;C)Furosemide&#10;D)Ethacrinic acid

Accepted Answer

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide is the IUPAC name for Hydrochlorothiazide, a thiazide diuretic used to treat high blood pressure and edema.

Question 4

Hydrazine hydrate is precursor for synthesis of&#10;A)Hydrochlorthiazide&#10;B)Acetazolamide&#10;C)Furosemide&#10;D)Ethacrinic acid

Accepted Answer

Acetazolamide is synthesized using hydrazine hydrate as a precursor. Hydrazine hydrate is used in the synthesis of various pharmaceuticals, including diuretics like acetazolamide, due to its role in introducing nitrogen atoms into organic compounds.

Question 5

IUPAC name of given drug is&#10;A)Benzoic acid, 5- (aminosulphonyl)-4-chloro-2-[(2-furanyl 1-methyl) amino]&#10;B)Benzoic acid, 3- (aminosulphonyl)-4-chloro-2-[(2-furanyl 1-methyl) amino]&#10;C)Benzoic acid, 5- (aminosulphonyl)-3-chloro-2-[(2-furanyl 1-methyl) amino]&#10;D)Benzoic acid, 3- (aminosulphonyl)-3-chloro-2-[(2-furanyl 1-methyl) amino]

Accepted Answer

The correct IUPAC name is Benzoic acid, 5- (aminosulphonyl)-4-chloro-2-[(2-furanyl 1-methyl) amino]. The numbering of the benzene ring starts from the carbon atom attached to the carboxylic acid group, which is assigned number 1. The chlorine atom is attached to carbon 4, the aminosulfonyl group is attached to carbon 5, and the (2-furanyl 1-methyl) amino group is attached to carbon 2.

Question 6

The structure of steroids is based on the ____________________skeleton.&#10;A)1,2-cyclopentanophenanthrene&#10;B)1,2-cyclohexanophenanthrene&#10;C)1,3-cyclopentanophenanthrene&#10;D)1,3-cyclohexanophenanthrene

Accepted Answer

The structure of steroids is based on the 1,2-cyclopentanophenanthrene skeleton, which is a fused ring structure that forms the core of all steroid molecules.

Question 7

2-(2,3-dichlorophenoxy acetic acid) and butyryl chloride are precursors for synthesis of&#10;A)Hydrochlorthiazide&#10;B)Acetazolamide&#10;C)Furosemide&#10;D)Ethacrinic acid

Accepted Answer

2-(2,3-dichlorophenoxy acetic acid) and butyryl chloride are used in the synthesis of Ethacrinic acid, which is a loop diuretic.

Deck 5: Chemical and Biological Aspects