Deck 5: ABO and H Blood Group Systems and Secretor Status

Question 1

A group A man marries a group AB woman.The father of the group A man was group O.What possible ABO phenotypes could be expected in the offspring?

A) Groups A, B, AB, and O
B) Groups A and B
C) Groups A, B, and AB
D) Groups A and AB

Answer 1

C
The group A man must be genotype AO because the O gene was inherited from his father.A Punnett square with a group AB yields three potential phenotypes for the children: A,B,and AB.

Question 2

Which of the following situations is most likely to cause intravascular hemolysis when an incompatible transfusion is given?

A) Group B packed cells to a group O recipient
B) Group A packed red cells to a group AB recipient
C) Group AB plasma to a group A recipient
D) Group AB plasma to a group O recipient

Answer 2

A
A group O recipient has anti-B that could potentially cause intravascular hemolysis if group B blood were transfused.

Question 3

A patient's red cells are agglutinated by anti-B,but not by anti-A.What is this patient's ABO phenotype?

A) Group B
B) Group O
C) Group AB
D) Group A

Answer 3

A
Anti-B reacts with the B antigen,which is the blood type identified.

Question 4

Approximately what is the percentage of individuals who demonstrate H in their saliva?

A) 15%
B) 50%
C) 80%
D) 98%

Question 5

What substances are found in the saliva of a group A person who also inherited the secretor gene?

A) A, H
B) H
C) A, Se
D) A, B, H

Question 6

What percentage of the group A population are type as A₂?

A) 1%
B) 10%
C) 20%
D) 35%

Question 7

Select the appropriate strategy if the results of red cell and serum testing in the ABO typing procedure have negative agglutination reactions.

A) Wash patient cells with warm saline.
B) Use polyclonal typing reagents.
C) Perform an autocontrol.
D) Incubate tubes at room temperature or 4° C with an autocontrol.

Question 8

To distinguish between an A₁ and A₂ blood type,which reagent is used?

A) Ulex europeaus lectin
B) Anti-A,B
C) Monoclonal anti-A
D) Dolichos biflorus lectin

Question 9

Given the following ABO phenotyping data:

What could be a plausible explanation for this discrepancy?

A) T-activation of red cells
B) Group O blood products given to group A
C) Rouleaux formation
D) Positive direct antiglobulin test

Question 10

What forward typing reagent can be used to confirm group O units before placing them in inventory?

A) Anti-A
B) Anti-B
C) Anti-A,B
D) Anti-H

Question 11

What ABO phenotype would agglutinate in the presence of anti-A,B produced by group O individuals?

A) A only
B) B only
C) A and B
D) O only

Question 12

A blood sample from a 90-year-old man was submitted to the blood bank for a type and screen before surgery.The forward type demonstrates as a group A,whereas the reverse type appears to be group AB.What is the most likely cause of the discrepancy?

A) Contaminated reagent antisera
B) Rouleaux formation
C) That the patient has autoantibodies
D) That patient has low-titer isoagglutinins

Question 13

What is the test procedure that combines patient's serum with commercial A₁ and B reagent red cells?

A) ABO forward grouping
B) ABO reverse grouping
C) Antibody screen
D) Antibody panel

Question 14

Predict the agglutination reaction of red cells from a Bombay phenotype when combined with anti-H lectin.

A) Strong 4+
B) Mixed field
C) Weak 1+
D) Negative

Question 15

What subgroup of A possesses the least amount of A antigen?

A) A₃
B) A_x
C) A₂
D) A_el

Question 16

Most "naturally occurring" ABO system antibodies fall into which immunoglobulin class?

A) IgA
B) IgM
C) IgE
D) IgG

Question 17

Why is it sometimes necessary to distinguish A₁ and A₂ blood types?

A) To resolve a discrepancy between the forward and reverse typing
B) To prevent A1 recipients from receiving A2 blood
C) To determine the secretor status of group A individuals
D) To prevent hemolytic disease of the newborn

Question 18

According to Landsteiner's rule (law),what ABO antibody will be detected in a group A individual's serum?

A) Anti-A
B) Anti-B
C) Anti-A,B
D) None

Question 19

Which ABO phenotype selection contains the most H antigen and the least H antigen,respectively,on the red cell's surface?

A) O, A₁B
B) A₂, A₁B
C) B, A
D) A₁B, O

Question 20

A recipient with group A phenotype requires a transfusion of 2 units of frozen plasma.Which of the following types are appropriate to select for transfusion?

A) AB and B
B) B and A
C) O and A
D) AB and A

Question 21

MATCHING
Match the immunodominant sugar that corresponds to the ABO system group or antigen.
a.D-galactose
b.L-fucose
c.N-acetylgalactosamine
d.None of the above
H antigen

Question 22

MATCHING
Match the immunodominant sugar that corresponds to the ABO system group or antigen.
a.D-galactose
b.L-fucose
c.N-acetylgalactosamine
d.None of the above
Bombay

Question 23

MATCHING
Match the immunodominant sugar that corresponds to the ABO system group or antigen.
a.D-galactose
b.L-fucose
c.N-acetylgalactosamine
d.None of the above
Group O

Question 24

MATCHING
Match the immunodominant sugar that corresponds to the ABO system group or antigen.
a.D-galactose
b.L-fucose
c.N-acetylgalactosamine
d.None of the above
Group B

Question 25

MATCHING
Match the immunodominant sugar that corresponds to the ABO system group or antigen.
a.D-galactose
b.L-fucose
c.N-acetylgalactosamine
d.None of the above
Group A