Deck 7: Other Red Cell Blood Group Systems, Human Leukocyte Antigens, and Platelet Antigens

Question 1

The major histocompatibility complex is located on chromosome 6 and is important in all the following immune functions except:

A) recognition of nonself.
B) graft rejection.
C) hemolysis.
D) coordination of cellular and humoral immunity.

Answer 1

C
The major histocompatibility complex codes for molecules on all nucleated tissues and cells to allow for immune recognition and response to foreign antigens.

Question 2

HLA matching between the donor and recipient is important for progenitor cell transplantation to avoid:

A) graft versus host disease (GVHD).
B) graft rejection.
C) transfusion reactions.
D) A and B.

Answer 2

D
HLA typing is essential to avoid GVHD and rejection in HPC transplants.

Question 3

Predict the probable antibody's identity if all red cells tested at room temperature are positive with a patient's serum except for cord cells.

A) Anti-Lu
B) Anti-Le^a
C) Anti-I
D) Anti-M

Answer 3

Anti-I

Question 4

Antibodies to Kidd,Kell,and Duffy blood group antigens share all the following characteristics except:

A) can cause hemolytic disease of the newborn.
B) usually detected only by the indirect antiglobulin test.
C) enhanced with enzyme treatment.
D) can cause transfusion reactions.

Question 5

Anti-Jsᵇ was identified in a patient scheduled for elective surgery later.What is the best approach to finding compatible blood?

A) Contact the rare donor registry since Js(b-) units are rare.
B) Request that family members be tested to determine if they share the same phenotype.
C) Screen donors from the black population because Js(b-) phenotype is common.
D) A and B are correct.

Question 6

Which of the following phenotypes is heterozygous?

A) Fy(a-b+)
B) Jk(a+b-)
C) Fy(a+b+)
D) Le(a+b-)

Question 7

K-positive donor red cells were mistakenly transfused to a recipient with anti-K.The patient's posttransfusion blood sample has a positive direct antiglobulin test with polyspecific antihuman globulin.The direct antiglobulin test is positive because anti-K is an __________ antibody that has sensitized the __________ cells in vivo.

A) IgG, donor's
B) IgM, donor's
C) IgG, recipient's
D) IgM, recipient's

Question 8

Red cells that phenotype as S-s- are also:

A) M-negative.
B) N-negative.
C) Tja-negative.
D) U-negative.

Question 9

Antibodies to which of the following blood group system show dosage (i.e.,are stronger with homozygous expression of the antigen)?

A) Lutheran
B) P
C) Duffy
D) Kell

Question 10

The mixed lymphocyte culture (MLC)is a procedure that has been used in HLA testing to determine:

A) class I HLA antigen determination.
B) class II HLA antigen determination.
C) HLA antibody identification.
D) compatibility testing for tissue typing.
E) B and D.

Question 11

What characterizes the Donath-Landsteiner antibody?

A) An IgG auto anti-P.
B) An IgM auto anti-I.
C) Anti-IH that reacts at cold temperatures.
D) An IgG anti-Pk.

Question 12

All the following statements are true regarding Lewis system antibodies except antibodies:

A) may be observed at the immediate-spin, 37° C, and antihuman globulin phases.
B) can be neutralized by Lewis substance.
C) may cause hemolysis in vitro.
D) do not react following enzyme treatment of cells.

Question 13

Which condition is often associated with the presence of anti-I?

A) Infectious mononucleosis
B) Mycoplasma pneumoniae infection
C) Pregnancy
D) Colon cancer

Question 14

A patient's antibody history listed an anti-Cellano.This antigen is also known as:

A) c in the Rh system.
B) k in the Kell system.
C) Cs in the Cost system.
D) SC in the Scianna system.

Question 15

What phenotype will be expressed when the Le,Se,and H genes are inherited?

A) Le(a+b+)
B) Le(a-b+)
C) Le(a-b-)
D) Le(a+b-)

Question 16

Which of the following blood group systems are structurally related to antigens of the P system?

A) MNS
B) ABH
C) Kell
D) Duffy

Question 17

Why are antibodies to Luᵇ antigen not commonly detected?

A) Lub antigen is of high incidence.
B) The antibodies do not cause transfusion reactions.
C) Lub antigen is not present on screening cells.
D) The antibodies react best at 4° C.

Question 18

Which of the following facts is not a characteristic of Kell system antibodies?

A) Usually clinically significant IgG antibodies
B) Best detected in indirect antiglobulin test phases
C) Lose reactivity with proteolytic enzyme reagents
D) Do not bind complement proteins

Question 19

Why have Lewis system antibodies not been implicated in hemolytic disease of the fetus and newborn?

A) The antigens are not fully developed at birth.
B) Lewis system antibodies do not cross the placenta.
C) The antibodies are not clinically significant.
D) All of the above are correct.

Question 20

Select the statement that is FALSE regarding anti-P1.

A) Anti-P1 will not react with enzyme-treated P1 positive red cells.
B) P2 individuals can make anti-P1.
C) Anti-P1 is clinically not significant.
D) Anti-P1 reacts best at room temperature.

Question 21

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-Antigens Yt? and Yt? are in this system

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 22

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-System associated with chronic granulomatous disease

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 23

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-Antibodies in this system often fall below detectable levels and are associated with delayed transfusion reactions

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 24

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-System associated with glycophorin A and B

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 25

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-Antibody to this antigen demonstrates weak mixed field reaction

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 26

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-Antigen of high incidence; its antibody can cause hemolytic transfusion reactions

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 27

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-Antibodies are sensitive to enzymes and have high-titer low-avidity characteristics

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 28

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-Antigen has a higher frequency in females

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 29

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-System associated with resistance to malaria

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy

Question 30

MATCHING
Match each characteristic with the appropriate blood group system.A selection may be used more than once.

-System associated with McLeod phenotype

A)Cartwright
B)MNSs
C)Kidd
D)Vel
E)Xg^a
F)Sd^a antigen
G)Chido/Rodgers
H)Kell
I)Duffy