Question 1

According to USP, the speed regulating device of the dissolution apparatus should be capable of maintaining the speed within limits of what % of the selected speed?&#10;A)1%&#10;B)2%&#10;C)4%&#10;D)5%

Accepted Answer

4%&#10;

Question 2

What is Primogel?&#10;A)Substituted HPMC for direct compression&#10;B)Modified MCC for direct compression&#10;C)Hydrogelling polymer for gel formation&#10;D)Modified starch for disintegration

Accepted Answer

Primogel is a modified starch used as a disintegrant in tablet formulations to facilitate the breakup of the tablet into smaller fragments in the digestive tract, thereby enhancing the dissolution of the drug for better absorption.

Question 3

Which filler can NOT be used for the preparation of tablets for amine containing basic drugs to avoid discoloration of the tablets?&#10;A)Dicalcium Phosphate&#10;B)Microcrystalline cellulose&#10;C)Starch&#10;D)Lactose

Accepted Answer

Lactose cannot be used for the preparation of tablets for amine-containing basic drugs to avoid discoloration because it can react with the amine groups to form a Maillard reaction product, leading to discoloration.

Question 4

Which of the following industrial dryer is used to dry tablet granules?&#10;A)Drum Dryer&#10;B)Fluid dryer&#10;C)Spray dryer&#10;D)Freeze Dryer

Accepted Answer

Fluid dryers are commonly used in the pharmaceutical industry to dry tablet granules because they provide efficient and uniform drying by suspending particles in a hot gas.

Question 5

A water soluble substance used as coating material in microencapsulation process is:&#10;A)Polyethylene&#10;B)Silicone&#10;C)HEC&#10;D)Paraffin

Accepted Answer

HEC, or Hydroxyethyl cellulose, is a water-soluble polymer used as a thickening and coating agent, making it suitable for microencapsulation processes that require a water-soluble coating material.

Question 6

One of the following is used as a pH dependent controlled release excipient.&#10;A)Carnauba wax&#10;B)HPMC Phthalate&#10;C)Methyl cellulose&#10;D)Glyceryl Monostearate

Accepted Answer

HPMC Phthalate (Hydroxypropyl Methylcellulose Phthalate) is used as a pH-dependent controlled release excipient because it dissolves at specific pH levels, allowing for targeted drug release in areas of the gastrointestinal tract with the appropriate pH.

Question 7

A retardant material that forms a hydrophilic matrix in the formulation of matrix tablets is.&#10;A)HPMC&#10;B)CAP&#10;C)Polyethylene&#10;D)Carnauba wax

Accepted Answer

HPMC (Hydroxypropyl Methylcellulose) is a hydrophilic polymer that forms a gel-like matrix when it comes into contact with water, making it an effective retardant material in the formulation of matrix tablets. This property allows for controlled release of the drug.

Question 8

Unless otherwise stated in the individual monograph of the pharmacopoeia, in the disintegration test for enteric coated tablets, first the dissolution is carried out in. A)0.1N HCl B)Phosphate buffer C)water D)0.1 M H₂SO₄

Accepted Answer

The answer of Unless otherwise stated in the individual monograph...

Question 9

Durability of a tablet to combined effects of shock and abrasion is evaluated by using.&#10;A)Hardness tester&#10;B)Disintegration test apparatus&#10;C)Friabilator&#10;D)Screw gauge

Accepted Answer

The friabilator is specifically designed to evaluate the durability of tablets under conditions of shock and abrasion, simulating the mechanical stresses tablets might encounter during manufacturing, packaging, shipping, and handling.

Deck 5: Pharmaceutical Formulation and Processing