Deck 2: Liposomes, Transdermal Drug Delivery, and Controlled Release Devices

Question 1

Liposomes have solubility

A)Lower
B)Higher
C)Both a and b
D)None

Answer 1

Lower

Question 2

Liposome phospholipids undergoes

A)Oxidation
B)Hydrolysis
C)Acetylation
D)Both a and b

Answer 2

Both a and b

Question 3

The diameter of Small unilamellar vesicles is

A)20-100nm
B)20-1000nm
C)10-100nm
D)100nm-400nm

Answer 3

20-100nm

Question 4

Intermediate sized unilamellar vesicles are prepared by

A)Sonication
B)High pressure extrusion technique
C)Detergent dialysis
D)Both b and c

Question 5

Tranfersome belongs to the classification according to

A)Composition
B)Application
C)Function
D)None of the above

Question 6

Liposomes with ___________number of lamella are called as "pauci -lamellar liposomes"

A)Lower
B)Higher
C)Single
D)None of the above

Question 7

Loading of the entrapped agents before/during the manufacture procedure is known as

A)Active loading
B)Passive loading
C)Both a and b
D)None of the above

Question 8

Passive Loading Technique includes

A)Lyophilization
B)Proliposomes
C)Solvent dispersion
D)Both a and b

Question 9

Drawback of Lipid hydration method is

A)Low internal volume
B)High encapsulation efficiency
C)Size distribution is homogenous
D)None of the above

Question 10

Tip of sonicator is directly engrossed into liposome dispersion in

A)Bath sonication
B)Probe sonication
C)None of the above
D)all

Question 11

The resulting liposomes from French pressure cell extrusion are ______than sonicated SUVs

A)Smaller
B)Equal
C)Larger
D)all

Question 12

To produce a microemulsion of small vesicles at least _______ circulations are required

A)at least 20 circulation but not greater than 200
B)10 circulations
C)at least 200 circulation but not greater than 2000
D)at least 2 circulations but not greater than 10

Question 13

Dried reconstituted vesicles method is performed in

A)Solvent dispersion
B)Mechanical dispersion
C)Both a and b
D)none

Question 14

Solvent vaporization is also known as

A)Ether injection
B)Ethanol injection
C)Double emulsification
D)Reverse-phase evaporation

Question 15

Amphotericin B liposomes are given

A)Lungs
B)Oral
C)Transdermal
D)Intravenous

Question 16

Ketoconazole liposomes are given by

A)Lungs
B)Oral
C)Transdermal
D)Intravenous

Question 17

Temperature used for Ether Injection method is______ or under reduced pressure

A)15-25 °C
B)55-65 °C
C)55-85 °C
D)None of the above

Question 18

Which of the following drugs cannot be given as transdermal administration?

A)Drugs with very short half-lives
B)Drugs with narrow therapeutic indices
C)Easy removal and termination
D)Drugs against peptic ulcer

Question 19

Which of the following characteristics is suitable for transdermal drug?

A)Large drug dose
B)Large molecular size
C)Drugs with narrow therapeutic indices
D)Drugs which are metabolized in the skin

Question 20

What are the characteristics of the monolithic devices?

A)The drug has a large therapeutic index
B)Aqueous solutions
C)Control drug release by partitioning the drug from the oil
D)Administration of emulsions

Question 21

The rate at which monolithic devices transfer drugs to the patient body is proportional to _______________ of time

A)Square of time
B)The square root of time
C)Twice the time
D)Half the time

Question 22

What are the characteristics of the reservoir or membrane devices?

A)The drug has a large therapeutic index
B)Drug permeation rate is high
C)Control drug release by partitioning the drug from the oil
D)Administration of emulsions

Question 23

What are the characteristics of the mixed monolithic-reservoir devices?

A)The drug has a large therapeutic index
B)Drug permeation rate is high
C)The drug-polymer matrix is layered by rate-controlling membrane
D)Administration of emulsions

Question 24

The absorption of the ophthalmic drug does not depend on which of the following?

A)Physicochemical properties of the permeating molecule
B)Drainage of tears
C)Output of tears
D)Size of the eyeball

Question 25

Which of the following is false in regarding reservoir devices?

A)These devices are used when the drug permeation rate is rapid
B)The release of the drug is controlled
C)Suitable for low therapeutic indices
D)The drug is contained in a powder form floating on liquid