Question 1

Which of the following is true for monolithic devices?&#10;A)These devices are used when the drug permeation rate is rapid&#10;B)The release of the drug is controlled&#10;C)Suitable for drugs with large therapeutic indices&#10;D)The drug is contained in a powder form floating on liquid

Accepted Answer

Suitable for drugs with large therapeutic indices&#10;

Question 2

The duration of action of parental controlled release systems can be extended up to what time?&#10;A)1 day&#10;B)1 week&#10;C)1 month&#10;D)Day, week, month even a year

Accepted Answer

Parenteral controlled release systems are designed to release drugs at a controlled rate over an extended period, which can range from a day to a week, a month, and even up to a year, depending on the formulation and mechanism of the drug delivery system.

Question 3

What is the drawback of parental controlled release systems?&#10;A)Injecting is a difficulty&#10;B)The drug cannot be easily removed once administered&#10;C)Can get easily precipitated in the injection site&#10;D)Rapid onset but fast excretion

Accepted Answer

The main drawback of parental controlled release systems is that once the drug is administered, it cannot be easily removed, which can be problematic if there are adverse reactions or if the dosage needs to be adjusted.

Question 4

Which one of the following should not be a characteristic of the vehicles or polymers which are used for parenteral formulations?&#10;A)Sterile&#10;B)Consists of pyrogen&#10;C)Nonirritating&#10;D)Biodegradable

Accepted Answer

Vehicles or polymers used for parenteral formulations must be sterile, nonirritating, and often biodegradable, but they should not contain pyrogens, which are substances that can cause fever when introduced into the body.

Question 5

With aqueous solutions, the drug releases can be controlled. Which of the following is not the right method of controlling?&#10;A)Increasing the viscosity&#10;B)By forming complexes with macromolecules&#10;C)Reducing the solubility of the parent drug&#10;D)Increasing the pH to make it highly basic

Accepted Answer

Increasing the pH to make a solution highly basic does not directly control drug release in aqueous solutions. Drug release can be controlled by modifying the drug's environment or characteristics, such as increasing viscosity, forming complexes, or reducing solubility, but simply making the solution more basic does not inherently control the release of the drug.

Question 6

Release of water-soluble drugs can be retarded by presenting it as ____________ suspension&#10;A)Oil&#10;B)Water&#10;C)Colloidal&#10;D)Freezing

Accepted Answer

Oil suspensions can retard the release of water-soluble drugs because the oil phase can act as a barrier to the dissolution and diffusion of the drug into the surrounding aqueous environment, slowing down its release rate.

Question 7

Larger particle size leads to ____________ dissolution&#10;A)Slower&#10;B)Faster&#10;C)Moderate&#10;D)Normal

Accepted Answer

Larger particle size leads to slower dissolution because there is less surface area for the solvent to act on, slowing down the rate at which the particles dissolve.

Question 8

Which of the following is a characteristic of microspheres?&#10;A)Free flowing powders&#10;B)Aqueous solutions&#10;C)Control drug release by partitioning the drug from the oil&#10;D)Administration of emulsions

Accepted Answer

Microspheres are free flowing powders that are used to control drug release by partitioning the drug from the oil.

Question 9

Which of the following is a characteristic of oil solutions?&#10;A)Free flowing powders&#10;B)Aqueous solutions&#10;C)Control drug release by partitioning the drug from the oil&#10;D)Administration of emulsions

Accepted Answer

Oil solutions can control drug release by partitioning the drug from the oil phase to the target site, which is a mechanism to modulate the drug's bioavailability and effectiveness.

Question 10

Which of the following is a characteristic of aqueous solutions?&#10;A)Free flowing powders&#10;B)Drug release can be increased by increasing viscosity&#10;C)Control drug release by partitioning the drug from the oil&#10;D)Administration of emulsions

Accepted Answer

Drug release can be increased by increasing viscosity in aqueous solutions.

Question 11

Which of the following is a characteristic of nanoparticles?&#10;A)Free flowing powders&#10;B)Aqueous solutions&#10;C)Control drug release by partitioning the drug from the oil&#10;D)Size range 10-100 nm

Accepted Answer

The answer of Which of the following is a characteristic...

Question 12

Which of the following is a characteristic of the parental controlled drug release system by liposomes?&#10;A)Free flowing powders&#10;B)Aqueous solutions&#10;C)Lipid bilayer enclosing the drug&#10;D)Administration of emulsions

Accepted Answer

The answer of Which of the following is a characteristic...

Question 13

Which of the following can be incorporated into a liposome?&#10;A)Only drugs and viruses&#10;B)Only Peptides and viruses due to similar characteristics&#10;C)Only viruses&#10;D)Drugs, peptides, viruses, bacteria

Accepted Answer

The answer of Which of the following can be incorporated...

Question 14

Which of the following is a characteristic of resealed erythrocytes?&#10;A)Nonimmunogenic&#10;B)Aqueous solutions&#10;C)Control drug release by partitioning the drug from the oil&#10;D)Size range 10-100 nm

Accepted Answer

The answer of Which of the following is a characteristic...

Question 15

Which of the following statement is false for osmotic pumps?&#10;A)The pump has three concentric circle&#10;B)The innermost is the drug reservoir&#10;C)The drug is contained a permeable polyester bag&#10;D)Outer most rigid rate controlling semipermeable membrane

Accepted Answer

The answer of Which of the following statement is false...

Question 16

Which of the following statement is true for osmotic pumps?&#10;A)The tube is made up of stainless steel&#10;B)The innermost is the drug reservoir in a no collapsible bag&#10;C)The drug is contained a permeable polyester bag&#10;D)The outer most cover is soft and easily permeable

Accepted Answer

The answer of Which of the following statement is true...

Question 17

Which of the following should not be a property of implants?&#10;A)Environmental stable&#10;B)Biostable&#10;C)Non-toxic&#10;D)Nonremovable

Accepted Answer

The answer of Which of the following should not be...

Question 18

Which is the disadvantage for implants?&#10;A)More effective&#10;B)More prolonged action&#10;C)Significantly small dose&#10;D)Need of microsurgery

Accepted Answer

The answer of Which is the disadvantage for implants?&#10;A)More effective&#10;B)More...

Question 19

Subcutaneous tissue is an ideal location for implants?

Accepted Answer

The answer of Subcutaneous tissue is an ideal location for...

Question 20

Which of the following drugs are used in implants?&#10;A)Pantoprazole&#10;B)Mannitol&#10;C)Amlodipine&#10;D)Morphine antagonist

Accepted Answer

The answer of Which of the following drugs are used...

Question 21

Which of the following is a false statement for vapour pressure pump?&#10;A)The device consists of two chambers&#10;B)A chamber contains the drug solution&#10;C)Drug solution chamber is separated by rigid walls&#10;D)Vapour chamber contains vaporizable fluids

Accepted Answer

The answer of Which of the following is a false...

Question 22

After implantation of a vapour pressure pump, the body has to get heated by exercising so that the&#10;volatile liquid vaporizes.

Accepted Answer

The answer of After implantation of a vapour pressure pump,...

Question 23

Which of the following is a characteristic of battery powered pumps?&#10;A)Free flowing powders&#10;B)The system is programmed to release drugs at a controlled rate&#10;C)Control drug release by partitioning the drug from the oil&#10;D)Administration of emulsions

Accepted Answer

The answer of Which of the following is a characteristic...

Question 24

The drug loading in resealed erythrocytes can be done by 1st immersing the cells in a buffered&#10;hypertonic solution.

Accepted Answer

The answer of The drug loading in resealed erythrocytes can...

Question 25

How are MLV liposomes made?&#10;A)2-10 bilayers of lipid&#10;B)Series of concentric bilayers of lipid&#10;C)The single bilayer of lipid&#10;D)100 bilayer of lipid

Accepted Answer

The answer of How are MLV liposomes made?&#10;A)2-10 bilayers of...

Question 26

How are OLV liposomes made?&#10;A)2-10 bilayers of lipid&#10;B)Series of concentric bilayers of lipid&#10;C)A single bilayer of lipid&#10;D)100 bilayer of lipid

Accepted Answer

The answer of How are OLV liposomes made?&#10;A)2-10 bilayers of...

Deck 3: Characteristics and Applications of Controlled Drug Release Systems