Deck 12: Oncology

Question 1

Which of the following tumor stages is correctly matched to the appropriate prostate cancer involvement or invasion?

A)Stage T2b is associated with tumor involvement of more than one half of one lobe but not both lobes of the prostate.
B)Stage T2c is associated with nonpalpable tumor involvement of both lobes of the prostate via needle biopsy.
C)Stage T3a is associated with tumor invasion of the prostate apex.
D)Stage T4 is associated with tumor invasion of the seminal vesicles.

Answer 1

Stage T2b is associated with tumor involvement of more than one half of one lobe but not both lobes of the prostate.

Question 2

According to GOG 122 (Randall), the survival rate of patients who have surgical stage III-IV endometrial cancer and receive adjuvant abdominopelvic irradiation compared to adjuvant chemotherapy is:

A)worse.
B)similar.
C)improved.
D)not able to be analyzed.

Answer 2

worse.

Question 3

A well-lateralized, stage T3N0 squamous cell carcinoma of the nasopharynx has at least a 15% risk of metastasis to the:

A)ipsilateral parotid lymph nodes.
B)ipsilateral submandibular lymph nodes.
C)posterior triangle lymph nodes bilaterally.
D)occipital lymph nodes bilaterally.

Answer 3

posterior triangle lymph nodes bilaterally.

Question 4

What is the second leading cause of lung cancer?

A)Exposure to arsenic
B)Exposure to asbestos
C)Exposure to benzene
D)Exposure to radon

Question 5

Which of the following chromosomal translocations is most commonly associated with Burkitt lymphoma?

A)t(8;14)
B)t(9;22)
C)t(11;14)
D)t(14;18)

Question 6

What is the most common secondary malignant neoplasm inside the radiation field for patients with retinoblastoma?

A)Squamous cell carcinoma
B)Non-Hodgkin lymphoma
C)Fibrosarcoma
D)Osteosarcoma

Question 7

Three different lung cancer radiation treatments are being assessed for maximum- tolerated dose. This study is an example of what type of clinical trial?

A)Phase I
B)Phase II
C)Phase III
D)Pilot

Question 8

Which of the following factors is the most important predictor of disease-free survival and overall survival in patients with breast cancer?

A)Tumor size
B)Mitotic index
C)Axillary lymph node status
D)Histopathologic tumor grade

Question 9

Which of the following diagnostic tests is most useful for determining the tumor stage of esophageal cancer?

A)Esophagogastroduodenoscopy
B)Endoscopic ultrasound
C)PET scan
D)CT scan

Question 10

Which of the following studies compared surgery alone versus surgery plus external-beam pelvic irradiation in patients with early-stage endometrial cancer and required all patients to undergo surgical staging with pelvic lymphadenectomy?

A)GOG 99 (Keys)
B)GOG 33 (Morrow)
C)PORTEC (Creutzberg)
D)Norwegian (Aalders)

Question 11

Which of the following findings is most likely to be caused by loss of function of right cranial nerve XII?

A)Deviation of the tongue to the left side with protrusion
B)Deviation of the tongue to the right side with protrusion
C)Loss of sweet taste on the right side of the tongue
D)Loss of salty taste on the right side of the tongue

Question 12

Which of the following statements about video-assisted thoracic surgery for patients with lung cancer is FALSE?

A)The postoperative period is shorter.
B)It decreases the risk of intraoperative bleeding.
C)It is a viable alternative to thoracotomy in patients who are frail.
D)Locoregional recurrence is increased.

Question 13

According to GOG 99 (Keys), which of the following sites is most likely to be associated with cancer recurrence in a patient who has early-stage endometrial cancer and undergoes TAH-BSO without adjuvant irradiation?

A)Liver
B)Vaginal vault
C)Pelvic lymph nodes
D)Paraaortic lymph nodes

Question 14

Which of the following laboratory tests is most appropriate for determining if a patient with acromegaly has responded favorably to radiation therapy?

A)Serum glucose level
B)Growth hormone (GH)
C)Thyroid stimulating hormone (TSH)
D)Insulin-like growth factor-1 (IGF-1)

Question 15

Which of the following soft tissue sarcomas is most likely to be found in a patient with neurofibromatosis, type 1?

A)Liposarcoma
B)Fibrosarcoma
C)Leiomyosarcoma
D)Malignant peripheral nerve sheath tumor

Question 16

Which of the following survival times is most likely to be associated with a patient who has a class II brain metastasis, based on the Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA)?

A)10.2 months
B)07.1 months
C)04.2 months
D)02.3 months

Question 17

Radiation-induced cell death in carcinomas typically occurs immediately after attempting to traverse which phase of the cell cycle?

A)G0
B)G1
C)G2
D)M

Question 18

Which of the following antigens is a T-cell marker?

A)CD7
B)CD20
C)CD30
D)CD40

Question 19

Which of the following statements about adenocarcinoma of the lung is true?

A)It is the most common histologic subtype.
B)It is treated differently than squamous cell carcinoma.
C)It is less likely to metastasize to the brain than other histologies.
D)It is rarely associated with TTF-1.

Question 20

A 9-month-old infant has a mass in the left flank, periorbital ecchymosis, and bone metastasis to the right femur. Biopsy results are consistent with neuroblastoma. What cancer stage would be most appropriate for this patient's condition?

A)Stage 2
B)Stage 3
C)Stage 4
D)Stage 4S

Question 21

Hypoxia adversely affects the treatment and management of cancers because it:

A)increases blood flow to the tumor.
B)impedes adequate blood flow to the tumor.
C)activates molecular pathways contributing to resistance.
D)causes dyspnea and tachypnea in the patient.

Question 22

What is the best method for minimizing bias in a national trial comparing two arms therapy regimens?

A)Randomization
B)Patient stratification
C)Univariate analysis of prognostic factors
D)Multivariate analysis of prognostic factors

Question 23

Which of the following primary bone tumors is most common?

A)Ewing sarcoma
B)Malignant giant cell tumor
C)Chondrosarcoma
D)Osteosarcoma

Question 24

Which of the following complications is NOT associated with a radical prostatectomy?

A)Proctitis
B)Erectile dysfunction
C)Urinary incontinence
D)Anastomotic stricture

Question 25

Which of the following FIGO stages is associated with a patient who has endometrial cancer with extension to the cervical stroma?

A)IC
B)IIA
C)IIB
D)IIIA