Deck 28: Drugs for Gastrointestinal Tract Disorders

Question 1

A pregnant woman complains of being constipated most days despite eating a well-balanced diet and drinking plenty of water.Which agent would provide the most physiological approach to treating her problem?

A) bisacodyl
B) sodium phosphate
C) senna
D) psyllium
E) castor oil

Answer 1

psyllium

Question 2

By which mechanism does lubiprostone relieve some cases of severe idiopathic constipation?

A) blockade of serotonin 5-HT₃ receptors
B) activation of serotonin 5-HT₄ receptors
C) inhibition of fluid reabsorption in the colon
D) stimulation of the parasympathetic nervous system
E) activation of chloride channels

Answer 2

activation of chloride channels

Question 3

Blockade of which receptors is responsible for the antiemetic effect of aprepitant?

A) histamine H₁
B) serotonin 5-HT₃
C) muscarinic acetylcholine M₁
D) dopamine D₂
E) neurokinin NK₁

Answer 3

neurokinin NK₁

Question 4

Which event is involved in the inhibition of gastric acid secretion by pantoprazole?

A) blockade of histamine H₂ receptors
B) competitive inhibition of H⁺, K⁺-ATPase
C) formation of an active drug metabolite
D) metabolism by cytochrome P450 2C19
E) stimulation of prostaglandin synthesis