Deck 11: Antianginal Drugs

Question 1

Which signaling mechanism participates in the vasodilative effect of nitroglycerin?

A) activation of nitric oxide synthase
B) inhibition of phosphodiesterase
C) inhibition of intracellular calcium release
D) activation of guanylate cyclase
E) activation of adenylate cyclase

Answer 1

activation of guanylate cyclase

Question 2

A patient is given a drug that decreases anginal episodes without reducing heart rate or blood pressure.Which mechanism is responsible for the beneficial effects of this drug?

A) increased utilization of glucose by the heart
B) improved cardiac diastolic function
C) inhibition of fatty acid oxidation in the heart
D) increased sodium influx into myocytes
E) increased calcium influx into myocytes

Answer 2

improved cardiac diastolic function

Question 3

Which drug reduces heart rate and increases coronary blood flow?

A) isosorbide mononitrate
B) atenolol
C) verapamil
D) ranolazine
E) felodipine

Answer 3

verapamil